The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania
Here we investigate the similarities in the kinetoplastid RNA editing process between human- and lizard-infecting Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from L. (V.) panamensis, L. (L.) mexicana and L. (L.) donovani species of human-infecting Leis...
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| Veröffentlicht in: | Gene 1999-07, Vol.235 (1), p.77-84 |
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| creator | Brewster, S. Barker, D.C. |
| description | Here we investigate the similarities in the kinetoplastid RNA editing process between human- and lizard-infecting
Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from
L. (V.) panamensis,
L. (L.) mexicana and
L. (L.) donovani species of human-infecting
Leishmania. These represent the first available sequences of this gene from
Leishmania species other than the lizard-infecting
L. tarentolae. The gene sequences are highly conserved, both over the edited and unedited parts of the gene, implying that the RNA editing process is likely to be highly conserved between
Leishmania species. Indeed, the first editing domain is absolutely conserved in all three
Leishmania species studied and
L. tarentolae. A phylogeny based on part of the ATPase subunit 6 gene placed the lizard-infecting
Leishmania within the monophyletic
Leishmania genus, supporting previous data which suggest that lizard- and human-infecting
Leishmania species are closely related. |
| doi_str_mv | 10.1016/S0378-1119(99)00207-3 |
| format | Article |
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Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from
L. (V.) panamensis,
L. (L.) mexicana and
L. (L.) donovani species of human-infecting
Leishmania. These represent the first available sequences of this gene from
Leishmania species other than the lizard-infecting
L. tarentolae. The gene sequences are highly conserved, both over the edited and unedited parts of the gene, implying that the RNA editing process is likely to be highly conserved between
Leishmania species. Indeed, the first editing domain is absolutely conserved in all three
Leishmania species studied and
L. tarentolae. A phylogeny based on part of the ATPase subunit 6 gene placed the lizard-infecting
Leishmania within the monophyletic
Leishmania genus, supporting previous data which suggest that lizard- and human-infecting
Leishmania species are closely related.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/S0378-1119(99)00207-3</identifier><identifier>PMID: 10415335</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adenosine Triphosphatases - chemistry ; Adenosine Triphosphatases - genetics ; Amino Acid Sequence ; Animals ; ATPase subunit 6 gene ; Base Sequence ; Consensus Sequence - genetics ; Conserved Sequence - genetics ; Cytochrome b Group - genetics ; DNA, Kinetoplast - genetics ; Evolution, Molecular ; Genes, Protozoan - genetics ; Genetic Variation - genetics ; Humans ; Kinetoplast ; Lacertilia ; Leishmania - classification ; Leishmania - enzymology ; Leishmania - genetics ; Leishmania donovani ; Leishmania mexicana ; Leishmania panamensis ; Leishmania tarentolae ; Lizards - parasitology ; Maxicircle ; Molecular Sequence Data ; Phylogeny ; RNA Editing - genetics ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; Sauroleishmania ; Sequence Alignment ; Trypanosoma ; Trypanosoma - genetics</subject><ispartof>Gene, 1999-07, Vol.235 (1), p.77-84</ispartof><rights>1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-14bd2cb234ed1436b16e40f14ad30262058e8df7f22f1605743e6759ffa326063</citedby><cites>FETCH-LOGICAL-c392t-14bd2cb234ed1436b16e40f14ad30262058e8df7f22f1605743e6759ffa326063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-1119(99)00207-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10415335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brewster, S.</creatorcontrib><creatorcontrib>Barker, D.C.</creatorcontrib><title>The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania</title><title>Gene</title><addtitle>Gene</addtitle><description>Here we investigate the similarities in the kinetoplastid RNA editing process between human- and lizard-infecting
Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from
L. (V.) panamensis,
L. (L.) mexicana and
L. (L.) donovani species of human-infecting
Leishmania. These represent the first available sequences of this gene from
Leishmania species other than the lizard-infecting
L. tarentolae. The gene sequences are highly conserved, both over the edited and unedited parts of the gene, implying that the RNA editing process is likely to be highly conserved between
Leishmania species. Indeed, the first editing domain is absolutely conserved in all three
Leishmania species studied and
L. tarentolae. A phylogeny based on part of the ATPase subunit 6 gene placed the lizard-infecting
Leishmania within the monophyletic
Leishmania genus, supporting previous data which suggest that lizard- and human-infecting
Leishmania species are closely related.</description><subject>Adenosine Triphosphatases - chemistry</subject><subject>Adenosine Triphosphatases - genetics</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>ATPase subunit 6 gene</subject><subject>Base Sequence</subject><subject>Consensus Sequence - genetics</subject><subject>Conserved Sequence - genetics</subject><subject>Cytochrome b Group - genetics</subject><subject>DNA, Kinetoplast - genetics</subject><subject>Evolution, Molecular</subject><subject>Genes, Protozoan - genetics</subject><subject>Genetic Variation - genetics</subject><subject>Humans</subject><subject>Kinetoplast</subject><subject>Lacertilia</subject><subject>Leishmania - classification</subject><subject>Leishmania - enzymology</subject><subject>Leishmania - genetics</subject><subject>Leishmania donovani</subject><subject>Leishmania mexicana</subject><subject>Leishmania panamensis</subject><subject>Leishmania tarentolae</subject><subject>Lizards - parasitology</subject><subject>Maxicircle</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>RNA Editing - genetics</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>Sauroleishmania</subject><subject>Sequence Alignment</subject><subject>Trypanosoma</subject><subject>Trypanosoma - genetics</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EomnhJ4B8Qu1hYWyvvesTiiq-pAgQhLPltceNUeIN9m75-PU4SYW41ZfRjJ7Xo3lfQp4xeMmAqVdfQXR9wxjTl1pfAXDoGvGALFjf6QZA9A_J4h9yRs5L-Q71SckfkzMGLZNCyAX5td4gXa4_24K0zMOc4kQVvcFUW_wxY3JI9xl9dFOh08ZO9MvHJa39FNMNjYW6MRXMt-jpgNNPxES38Y_NvqE2ebqZdzY1MQV0R8EKY9nUUbRPyKNgtwWf3tUL8u3tm_X1-2b16d2H6-WqcULzqWHt4LkbuGjRs1aogSlsIbDWegFccZA99j50gfPAFMiuFag6qUOwgitQ4oK8OP27z2O9p0xmF4vD7dYmHOdilNas4y2_F2S9qMZLqKA8gS6PpWQMZp_jzubfhoE5ZGOO2ZiD8UZrc8zGiKp7frdgHnbo_1OdwqjA6xOA1Y_biNkUFw8J-Jirf8aP8Z4VfwG3iZ2q</recordid><startdate>19990722</startdate><enddate>19990722</enddate><creator>Brewster, S.</creator><creator>Barker, D.C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19990722</creationdate><title>The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania</title><author>Brewster, S. ; Barker, D.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-14bd2cb234ed1436b16e40f14ad30262058e8df7f22f1605743e6759ffa326063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine Triphosphatases - chemistry</topic><topic>Adenosine Triphosphatases - genetics</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>ATPase subunit 6 gene</topic><topic>Base Sequence</topic><topic>Consensus Sequence - genetics</topic><topic>Conserved Sequence - genetics</topic><topic>Cytochrome b Group - genetics</topic><topic>DNA, Kinetoplast - genetics</topic><topic>Evolution, Molecular</topic><topic>Genes, Protozoan - genetics</topic><topic>Genetic Variation - genetics</topic><topic>Humans</topic><topic>Kinetoplast</topic><topic>Lacertilia</topic><topic>Leishmania - classification</topic><topic>Leishmania - enzymology</topic><topic>Leishmania - genetics</topic><topic>Leishmania donovani</topic><topic>Leishmania mexicana</topic><topic>Leishmania panamensis</topic><topic>Leishmania tarentolae</topic><topic>Lizards - parasitology</topic><topic>Maxicircle</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>RNA Editing - genetics</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>Sauroleishmania</topic><topic>Sequence Alignment</topic><topic>Trypanosoma</topic><topic>Trypanosoma - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brewster, S.</creatorcontrib><creatorcontrib>Barker, D.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brewster, S.</au><au>Barker, D.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1999-07-22</date><risdate>1999</risdate><volume>235</volume><issue>1</issue><spage>77</spage><epage>84</epage><pages>77-84</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Here we investigate the similarities in the kinetoplastid RNA editing process between human- and lizard-infecting
Leishmania species. We present the sequence of the maxicircle-encoded ATPase subunit 6 gene from
L. (V.) panamensis,
L. (L.) mexicana and
L. (L.) donovani species of human-infecting
Leishmania. These represent the first available sequences of this gene from
Leishmania species other than the lizard-infecting
L. tarentolae. The gene sequences are highly conserved, both over the edited and unedited parts of the gene, implying that the RNA editing process is likely to be highly conserved between
Leishmania species. Indeed, the first editing domain is absolutely conserved in all three
Leishmania species studied and
L. tarentolae. A phylogeny based on part of the ATPase subunit 6 gene placed the lizard-infecting
Leishmania within the monophyletic
Leishmania genus, supporting previous data which suggest that lizard- and human-infecting
Leishmania species are closely related.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10415335</pmid><doi>10.1016/S0378-1119(99)00207-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Gene, 1999-07, Vol.235 (1), p.77-84 |
| issn | 0378-1119 1879-0038 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69917242 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Amino Acid Sequence Animals ATPase subunit 6 gene Base Sequence Consensus Sequence - genetics Conserved Sequence - genetics Cytochrome b Group - genetics DNA, Kinetoplast - genetics Evolution, Molecular Genes, Protozoan - genetics Genetic Variation - genetics Humans Kinetoplast Lacertilia Leishmania - classification Leishmania - enzymology Leishmania - genetics Leishmania donovani Leishmania mexicana Leishmania panamensis Leishmania tarentolae Lizards - parasitology Maxicircle Molecular Sequence Data Phylogeny RNA Editing - genetics RNA, Messenger - chemistry RNA, Messenger - genetics Sauroleishmania Sequence Alignment Trypanosoma Trypanosoma - genetics |
| title | The ATPase subunit 6 gene sequence predicts that RNA editing is conserved between lizard- and human-infecting Leishmania |
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