Postischemic Hypothermia and IL-10 Treatment Provide Long-Lasting Neuroprotection of CA1 Hippocampus Following Transient Global Ischemia in Rats

Experimental studies have demonstrated that postischemic therapeutic interventions may delay rather than provide long-lasting neuroprotection. The purpose of this study was to determine whether mild hypothermia (33–34°C) combined with the anti-inflammatory cytokine interleukin-10 (IL-10) would prote...

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Veröffentlicht in:	Experimental neurology 1999-08, Vol.158 (2), p.444-450
Hauptverfasser:	Dietrich, W.Dalton, Busto, Raul, Bethea, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory agents Biological and medical sciences Blood Pressure cytokines Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology hypothermia Hypothermia, Induced IL-10 Interleukin-10 - therapeutic use Ischemic Attack, Transient - pathology Ischemic Attack, Transient - physiopathology Ischemic Attack, Transient - therapy Male Medical sciences Neurology neuronal damage Neurons - drug effects Neurons - pathology Neurons - physiology Neuroprotective Agents - therapeutic use Pyramidal Cells - drug effects Pyramidal Cells - pathology Pyramidal Cells - physiology Rats Rats, Wistar temperature Time Factors Vascular diseases and vascular malformations of the nervous system
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