Effect of a Hemodiafiltration Session with On-Line Regeneration of the Ultrafiltrate on Oxidative Stress : Comparative Study with Conventional Hemodialysis with Polysulfone
The influence of a dialysis session using hemodiafiltration with on-line regeneration of the ultrafiltrate (HFR) is compared with that of a conventional hemodialysis session with polysulfone (HD-PS) and with a group of healthy individuals. Total antioxidant capacity (TAC), antioxidants, i.e., supero...
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| Veröffentlicht in: | Blood purification 2008, Vol.26 (6), p.505-510 |
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| creator | GONZALEZ-DIEZ, B CAVIA, M TORRES, G ABAIGAR, P MUNIZ, P |
| description | The influence of a dialysis session using hemodiafiltration with on-line regeneration of the ultrafiltrate (HFR) is compared with that of a conventional hemodialysis session with polysulfone (HD-PS) and with a group of healthy individuals.
Total antioxidant capacity (TAC), antioxidants, i.e., superoxide dismutase (SOD) glutathione peroxidase (GPX), reduced glutathione (GSH) and catalase, and biomarkers of oxidative stress were evaluated in plasma, whole blood and lymphocytes.
The study showed decreased plasma TAC, decreased activities of antioxidant enzymes and decreased GSH levels along with increased thiobarbituric-acid-reactive substances and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in lymphocytes. The antioxidants and biomarkers of lipid and protein damage after dialysis sessions with HFR were similar or better than following HD-PS. Thus, the blood GPX activity was comparable to that of healthy controls and significantly better than following HD-PS. An increase in 8-OHdG levels was observed in the HD-PS group after dialysis but not in the HFR group.
These results show that HFR induces less oxidative stress than HD-PS. |
| doi_str_mv | 10.1159/000163848 |
| format | Article |
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Total antioxidant capacity (TAC), antioxidants, i.e., superoxide dismutase (SOD) glutathione peroxidase (GPX), reduced glutathione (GSH) and catalase, and biomarkers of oxidative stress were evaluated in plasma, whole blood and lymphocytes.
The study showed decreased plasma TAC, decreased activities of antioxidant enzymes and decreased GSH levels along with increased thiobarbituric-acid-reactive substances and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in lymphocytes. The antioxidants and biomarkers of lipid and protein damage after dialysis sessions with HFR were similar or better than following HD-PS. Thus, the blood GPX activity was comparable to that of healthy controls and significantly better than following HD-PS. An increase in 8-OHdG levels was observed in the HD-PS group after dialysis but not in the HFR group.
These results show that HFR induces less oxidative stress than HD-PS.</description><identifier>ISSN: 0253-5068</identifier><identifier>EISSN: 1421-9735</identifier><identifier>DOI: 10.1159/000163848</identifier><identifier>PMID: 18931477</identifier><identifier>CODEN: BLPUDO</identifier><language>eng</language><publisher>Basel: Karger</publisher><subject>Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antioxidants - analysis ; Biological and medical sciences ; Biomarkers - analysis ; Biomarkers - blood ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - analysis ; Emergency and intensive care: renal failure. Dialysis management ; Glutathione Peroxidase - analysis ; Hemodiafiltration - adverse effects ; Hemodiafiltration - methods ; Humans ; Intensive care medicine ; Lymphocytes - chemistry ; Medical sciences ; Middle Aged ; Online Systems ; Oxidative Stress ; Polymers ; Sulfones ; Thiobarbituric Acid Reactive Substances - analysis</subject><ispartof>Blood purification, 2008, Vol.26 (6), p.505-510</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright 2008 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20944062$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18931477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GONZALEZ-DIEZ, B</creatorcontrib><creatorcontrib>CAVIA, M</creatorcontrib><creatorcontrib>TORRES, G</creatorcontrib><creatorcontrib>ABAIGAR, P</creatorcontrib><creatorcontrib>MUNIZ, P</creatorcontrib><title>Effect of a Hemodiafiltration Session with On-Line Regeneration of the Ultrafiltrate on Oxidative Stress : Comparative Study with Conventional Hemodialysis with Polysulfone</title><title>Blood purification</title><addtitle>Blood Purif</addtitle><description>The influence of a dialysis session using hemodiafiltration with on-line regeneration of the ultrafiltrate (HFR) is compared with that of a conventional hemodialysis session with polysulfone (HD-PS) and with a group of healthy individuals.
Total antioxidant capacity (TAC), antioxidants, i.e., superoxide dismutase (SOD) glutathione peroxidase (GPX), reduced glutathione (GSH) and catalase, and biomarkers of oxidative stress were evaluated in plasma, whole blood and lymphocytes.
The study showed decreased plasma TAC, decreased activities of antioxidant enzymes and decreased GSH levels along with increased thiobarbituric-acid-reactive substances and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in lymphocytes. The antioxidants and biomarkers of lipid and protein damage after dialysis sessions with HFR were similar or better than following HD-PS. Thus, the blood GPX activity was comparable to that of healthy controls and significantly better than following HD-PS. An increase in 8-OHdG levels was observed in the HD-PS group after dialysis but not in the HFR group.
These results show that HFR induces less oxidative stress than HD-PS.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - analysis</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Glutathione Peroxidase - analysis</subject><subject>Hemodiafiltration - adverse effects</subject><subject>Hemodiafiltration - methods</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Lymphocytes - chemistry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Online Systems</subject><subject>Oxidative Stress</subject><subject>Polymers</subject><subject>Sulfones</subject><subject>Thiobarbituric Acid Reactive Substances - analysis</subject><issn>0253-5068</issn><issn>1421-9735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtP6zAQhS0EgvJY8AeQN7AL2PErvrurqjykSkU81pWTjC--SuwSJ0D_Ez8SV01ZHc3Md45GB6FzSq4pFfqGEEIlK3ixhyaU5zTTiol9NCG5YJkgsjhCxzH-TxSXQh-iI1poRrlSE_Q9sxaqHgeLDb6HNtTOWNf0neld8PgZYtzop-vf8MJnc-cBP8E_8DASydi_AX7dWEYj4LRffLk6ER-An_supeA_eBralel2y6Feb2OnwX-A34SZZvdCs44ubs-PIQ1DY4OHU3RgTRPhbNQT9HI7e5neZ_PF3cP07zxbFVxltaxqKkHlXIEpVQ3aslIpXQutK2OlrhgYwRUpBNOpqdJakxOpZAWSljRnJ-hqG7vqwvsAsV-2LlbQNMZDGOJSak2lkDqBFyM4lC3Uy1XnWtOtl7t6E3A5AiZWprGd8ZWLv1xONOdE5uwHRUSMNw</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>GONZALEZ-DIEZ, B</creator><creator>CAVIA, M</creator><creator>TORRES, G</creator><creator>ABAIGAR, P</creator><creator>MUNIZ, P</creator><general>Karger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Effect of a Hemodiafiltration Session with On-Line Regeneration of the Ultrafiltrate on Oxidative Stress : Comparative Study with Conventional Hemodialysis with Polysulfone</title><author>GONZALEZ-DIEZ, B ; CAVIA, M ; TORRES, G ; ABAIGAR, P ; MUNIZ, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p847-d6cd16e7247eab7de9f3b779d599caf69c3ea54708539973bffa20676ce61b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Deoxyguanosine - analogs & derivatives</topic><topic>Deoxyguanosine - analysis</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Glutathione Peroxidase - analysis</topic><topic>Hemodiafiltration - adverse effects</topic><topic>Hemodiafiltration - methods</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Lymphocytes - chemistry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Online Systems</topic><topic>Oxidative Stress</topic><topic>Polymers</topic><topic>Sulfones</topic><topic>Thiobarbituric Acid Reactive Substances - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GONZALEZ-DIEZ, B</creatorcontrib><creatorcontrib>CAVIA, M</creatorcontrib><creatorcontrib>TORRES, G</creatorcontrib><creatorcontrib>ABAIGAR, P</creatorcontrib><creatorcontrib>MUNIZ, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Blood purification</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GONZALEZ-DIEZ, B</au><au>CAVIA, M</au><au>TORRES, G</au><au>ABAIGAR, P</au><au>MUNIZ, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of a Hemodiafiltration Session with On-Line Regeneration of the Ultrafiltrate on Oxidative Stress : Comparative Study with Conventional Hemodialysis with Polysulfone</atitle><jtitle>Blood purification</jtitle><addtitle>Blood Purif</addtitle><date>2008</date><risdate>2008</risdate><volume>26</volume><issue>6</issue><spage>505</spage><epage>510</epage><pages>505-510</pages><issn>0253-5068</issn><eissn>1421-9735</eissn><coden>BLPUDO</coden><abstract>The influence of a dialysis session using hemodiafiltration with on-line regeneration of the ultrafiltrate (HFR) is compared with that of a conventional hemodialysis session with polysulfone (HD-PS) and with a group of healthy individuals.
Total antioxidant capacity (TAC), antioxidants, i.e., superoxide dismutase (SOD) glutathione peroxidase (GPX), reduced glutathione (GSH) and catalase, and biomarkers of oxidative stress were evaluated in plasma, whole blood and lymphocytes.
The study showed decreased plasma TAC, decreased activities of antioxidant enzymes and decreased GSH levels along with increased thiobarbituric-acid-reactive substances and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels in lymphocytes. The antioxidants and biomarkers of lipid and protein damage after dialysis sessions with HFR were similar or better than following HD-PS. Thus, the blood GPX activity was comparable to that of healthy controls and significantly better than following HD-PS. An increase in 8-OHdG levels was observed in the HD-PS group after dialysis but not in the HFR group.
These results show that HFR induces less oxidative stress than HD-PS.</abstract><cop>Basel</cop><pub>Karger</pub><pmid>18931477</pmid><doi>10.1159/000163848</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Karger Journals; Alma/SFX Local Collection |
| subjects | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antioxidants - analysis Biological and medical sciences Biomarkers - analysis Biomarkers - blood Deoxyguanosine - analogs & derivatives Deoxyguanosine - analysis Emergency and intensive care: renal failure. Dialysis management Glutathione Peroxidase - analysis Hemodiafiltration - adverse effects Hemodiafiltration - methods Humans Intensive care medicine Lymphocytes - chemistry Medical sciences Middle Aged Online Systems Oxidative Stress Polymers Sulfones Thiobarbituric Acid Reactive Substances - analysis |
| title | Effect of a Hemodiafiltration Session with On-Line Regeneration of the Ultrafiltrate on Oxidative Stress : Comparative Study with Conventional Hemodialysis with Polysulfone |
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