Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers
Background: As a test of possible muscarinic up-regulation, the cortisol response to intravenous (IV) physostigmine (an anticholinesterase) was measured in 9 elderly volunteers before and after chronic cholinergic blockade with the muscarinic cholinergic antagonist scopolamine. Methods: Each of the...
Gespeichert in:
Veröffentlicht in: | Biological psychiatry (1969) 1999-07, Vol.46 (2), p.189-195 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 195 |
---|---|
container_issue | 2 |
container_start_page | 189 |
container_title | Biological psychiatry (1969) |
container_volume | 46 |
creator | Dukoff, Ruth Wilkinson, Charles W Lasser, Robert Friz, Judy Conway, Anne Bahro, Marcel Peskind, Elaine R Sunderland, Trey |
description | Background: As a test of possible muscarinic up-regulation, the cortisol response to intravenous (IV) physostigmine (an anticholinesterase) was measured in 9 elderly volunteers before and after chronic cholinergic blockade with the muscarinic cholinergic antagonist scopolamine.
Methods: Each of the 9 elderly control subjects was given two physostigmine (0.5 mg IV) infusions separated by 21 doses of nightly scopolamine (1.2 mg p.o.). No scopolamine was administered the night before infusions, and glycopyrrolate (0.2 mg IV) was administered prior to physostigmine to block its peripheral effects. Vital signs were monitored and blood samples were collected at six time points surrounding the physostigmine infusion (−10, +10, +20, +30, +50, and +70 min). Behavioral measures and cognitive tests were administered prior to and 30 min after the physostigmine.
Results: The cortisol response to physostigmine was greater after the second (post-chronic scopolamine) infusion study compared to the first (
p < .05) as measured by an area under the curve analysis of all time points. When individual time points were compared, the mean cortisol response was significantly increased after the second physostigmine infusion at the +50- and +70-min time points (
p < .05). There were no significant changes in behavioral rating scales, cognitive tests, or vital signs between the two physostigmine infusion study days.
Conclusions: This study demonstrates increased hypothalamic–pituitary–adrenocortical axis responsivity to a central nervous system cholinergic stimulus after chronic muscarinic blockade in 9 elderly control subjects. It also gives further evidence to support previous suggestions of muscarinic plasticity, specifically postsynaptic up-regulation, in the aging brain following exposure to chronic anticholinergic treatment. |
doi_str_mv | 10.1016/S0006-3223(98)00286-8 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69915640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006322398002868</els_id><sourcerecordid>69915640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-3bb4c5b078cd1a28e1f496811de8a4270a6f6e2c76cce481b1241ad86fda40e63</originalsourceid><addsrcrecordid>eNqFkEtP3DAQgK0KVLbQn9AqB4TKIcXjeB3nhBBqAQmJStBTD5ZjT3bdem2ws0j77_E-VLhxmhnNNw99hHwB-h0oiLN7SqmoG8aab508pZRJUcsPZAKybWrGKdsjk__IAfmU899StozBR3IAlIMUXTMhf37NVznm0c0WLmBl5tp7DDOsehxiwkoHW-lhxFRaKQZnSoy-oGlW8t5H809brFyo0FtMflU9R78MI2LKR2R_0D7j5108JL9__ni4vK5v765uLi9ua9N0dKybvudm2tNWGguaSYSBd0ICWJSas5ZqMQhkphXGIJfQA-OgrRSD1ZyiaA7JyXbvY4pPS8yjWrhs0HsdMC6zEl0HU8FpAadb0KSYc8JBPSa30GmlgKq1VbWxqtbKVCfVxqqSZe7r7sCyX6B9M7XVWIDjHaCz0X5IOhiXXzkpgTXrPedbDIuNZ4dJZeMwGLQuoRmVje6dT14AcM-U-w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69915640</pqid></control><display><type>article</type><title>Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Dukoff, Ruth ; Wilkinson, Charles W ; Lasser, Robert ; Friz, Judy ; Conway, Anne ; Bahro, Marcel ; Peskind, Elaine R ; Sunderland, Trey</creator><creatorcontrib>Dukoff, Ruth ; Wilkinson, Charles W ; Lasser, Robert ; Friz, Judy ; Conway, Anne ; Bahro, Marcel ; Peskind, Elaine R ; Sunderland, Trey</creatorcontrib><description>Background: As a test of possible muscarinic up-regulation, the cortisol response to intravenous (IV) physostigmine (an anticholinesterase) was measured in 9 elderly volunteers before and after chronic cholinergic blockade with the muscarinic cholinergic antagonist scopolamine.
Methods: Each of the 9 elderly control subjects was given two physostigmine (0.5 mg IV) infusions separated by 21 doses of nightly scopolamine (1.2 mg p.o.). No scopolamine was administered the night before infusions, and glycopyrrolate (0.2 mg IV) was administered prior to physostigmine to block its peripheral effects. Vital signs were monitored and blood samples were collected at six time points surrounding the physostigmine infusion (−10, +10, +20, +30, +50, and +70 min). Behavioral measures and cognitive tests were administered prior to and 30 min after the physostigmine.
Results: The cortisol response to physostigmine was greater after the second (post-chronic scopolamine) infusion study compared to the first (
p < .05) as measured by an area under the curve analysis of all time points. When individual time points were compared, the mean cortisol response was significantly increased after the second physostigmine infusion at the +50- and +70-min time points (
p < .05). There were no significant changes in behavioral rating scales, cognitive tests, or vital signs between the two physostigmine infusion study days.
Conclusions: This study demonstrates increased hypothalamic–pituitary–adrenocortical axis responsivity to a central nervous system cholinergic stimulus after chronic muscarinic blockade in 9 elderly control subjects. It also gives further evidence to support previous suggestions of muscarinic plasticity, specifically postsynaptic up-regulation, in the aging brain following exposure to chronic anticholinergic treatment.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/S0006-3223(98)00286-8</identifier><identifier>PMID: 10418693</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Aging ; Aging - physiology ; Alzheimer’s ; Biological and medical sciences ; Brief Psychiatric Rating Scale ; Cholinesterase Inhibitors - pharmacology ; Cognition Disorders - diagnosis ; cortisol ; Depressive Disorder - diagnosis ; Depressive Disorder - psychology ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects. Models. Methods ; Glycopyrrolate - pharmacology ; Humans ; Hydrocortisone - blood ; Hypothalamo-Hypophyseal System - drug effects ; Injections, Intravenous ; Male ; Muscarinic Antagonists - pharmacology ; neuroendocrine ; Neuronal Plasticity - drug effects ; physostigmine ; Physostigmine - pharmacology ; Pituitary-Adrenal System - drug effects ; plasticity ; Presynaptic Terminals - drug effects ; Receptors, Muscarinic - drug effects ; scopolamine ; Scopolamine - pharmacology ; Severity of Illness Index ; Time Factors ; Up-Regulation - drug effects ; Vertebrates: nervous system and sense organs</subject><ispartof>Biological psychiatry (1969), 1999-07, Vol.46 (2), p.189-195</ispartof><rights>1999 Society of Biological Psychiatry</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-3bb4c5b078cd1a28e1f496811de8a4270a6f6e2c76cce481b1241ad86fda40e63</citedby><cites>FETCH-LOGICAL-c390t-3bb4c5b078cd1a28e1f496811de8a4270a6f6e2c76cce481b1241ad86fda40e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3223(98)00286-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1881238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10418693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dukoff, Ruth</creatorcontrib><creatorcontrib>Wilkinson, Charles W</creatorcontrib><creatorcontrib>Lasser, Robert</creatorcontrib><creatorcontrib>Friz, Judy</creatorcontrib><creatorcontrib>Conway, Anne</creatorcontrib><creatorcontrib>Bahro, Marcel</creatorcontrib><creatorcontrib>Peskind, Elaine R</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><title>Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background: As a test of possible muscarinic up-regulation, the cortisol response to intravenous (IV) physostigmine (an anticholinesterase) was measured in 9 elderly volunteers before and after chronic cholinergic blockade with the muscarinic cholinergic antagonist scopolamine.
Methods: Each of the 9 elderly control subjects was given two physostigmine (0.5 mg IV) infusions separated by 21 doses of nightly scopolamine (1.2 mg p.o.). No scopolamine was administered the night before infusions, and glycopyrrolate (0.2 mg IV) was administered prior to physostigmine to block its peripheral effects. Vital signs were monitored and blood samples were collected at six time points surrounding the physostigmine infusion (−10, +10, +20, +30, +50, and +70 min). Behavioral measures and cognitive tests were administered prior to and 30 min after the physostigmine.
Results: The cortisol response to physostigmine was greater after the second (post-chronic scopolamine) infusion study compared to the first (
p < .05) as measured by an area under the curve analysis of all time points. When individual time points were compared, the mean cortisol response was significantly increased after the second physostigmine infusion at the +50- and +70-min time points (
p < .05). There were no significant changes in behavioral rating scales, cognitive tests, or vital signs between the two physostigmine infusion study days.
Conclusions: This study demonstrates increased hypothalamic–pituitary–adrenocortical axis responsivity to a central nervous system cholinergic stimulus after chronic muscarinic blockade in 9 elderly control subjects. It also gives further evidence to support previous suggestions of muscarinic plasticity, specifically postsynaptic up-regulation, in the aging brain following exposure to chronic anticholinergic treatment.</description><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Alzheimer’s</subject><subject>Biological and medical sciences</subject><subject>Brief Psychiatric Rating Scale</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Cognition Disorders - diagnosis</subject><subject>cortisol</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - psychology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. Methods</subject><subject>Glycopyrrolate - pharmacology</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hypothalamo-Hypophyseal System - drug effects</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>neuroendocrine</subject><subject>Neuronal Plasticity - drug effects</subject><subject>physostigmine</subject><subject>Physostigmine - pharmacology</subject><subject>Pituitary-Adrenal System - drug effects</subject><subject>plasticity</subject><subject>Presynaptic Terminals - drug effects</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>scopolamine</subject><subject>Scopolamine - pharmacology</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Up-Regulation - drug effects</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAQgK0KVLbQn9AqB4TKIcXjeB3nhBBqAQmJStBTD5ZjT3bdem2ws0j77_E-VLhxmhnNNw99hHwB-h0oiLN7SqmoG8aab508pZRJUcsPZAKybWrGKdsjk__IAfmU899StozBR3IAlIMUXTMhf37NVznm0c0WLmBl5tp7DDOsehxiwkoHW-lhxFRaKQZnSoy-oGlW8t5H809brFyo0FtMflU9R78MI2LKR2R_0D7j5108JL9__ni4vK5v765uLi9ua9N0dKybvudm2tNWGguaSYSBd0ICWJSas5ZqMQhkphXGIJfQA-OgrRSD1ZyiaA7JyXbvY4pPS8yjWrhs0HsdMC6zEl0HU8FpAadb0KSYc8JBPSa30GmlgKq1VbWxqtbKVCfVxqqSZe7r7sCyX6B9M7XVWIDjHaCz0X5IOhiXXzkpgTXrPedbDIuNZ4dJZeMwGLQuoRmVje6dT14AcM-U-w</recordid><startdate>19990715</startdate><enddate>19990715</enddate><creator>Dukoff, Ruth</creator><creator>Wilkinson, Charles W</creator><creator>Lasser, Robert</creator><creator>Friz, Judy</creator><creator>Conway, Anne</creator><creator>Bahro, Marcel</creator><creator>Peskind, Elaine R</creator><creator>Sunderland, Trey</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990715</creationdate><title>Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers</title><author>Dukoff, Ruth ; Wilkinson, Charles W ; Lasser, Robert ; Friz, Judy ; Conway, Anne ; Bahro, Marcel ; Peskind, Elaine R ; Sunderland, Trey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-3bb4c5b078cd1a28e1f496811de8a4270a6f6e2c76cce481b1241ad86fda40e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Alzheimer’s</topic><topic>Biological and medical sciences</topic><topic>Brief Psychiatric Rating Scale</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Cognition Disorders - diagnosis</topic><topic>cortisol</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - psychology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Models. Methods</topic><topic>Glycopyrrolate - pharmacology</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hypothalamo-Hypophyseal System - drug effects</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>neuroendocrine</topic><topic>Neuronal Plasticity - drug effects</topic><topic>physostigmine</topic><topic>Physostigmine - pharmacology</topic><topic>Pituitary-Adrenal System - drug effects</topic><topic>plasticity</topic><topic>Presynaptic Terminals - drug effects</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>scopolamine</topic><topic>Scopolamine - pharmacology</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Up-Regulation - drug effects</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dukoff, Ruth</creatorcontrib><creatorcontrib>Wilkinson, Charles W</creatorcontrib><creatorcontrib>Lasser, Robert</creatorcontrib><creatorcontrib>Friz, Judy</creatorcontrib><creatorcontrib>Conway, Anne</creatorcontrib><creatorcontrib>Bahro, Marcel</creatorcontrib><creatorcontrib>Peskind, Elaine R</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dukoff, Ruth</au><au>Wilkinson, Charles W</au><au>Lasser, Robert</au><au>Friz, Judy</au><au>Conway, Anne</au><au>Bahro, Marcel</au><au>Peskind, Elaine R</au><au>Sunderland, Trey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>1999-07-15</date><risdate>1999</risdate><volume>46</volume><issue>2</issue><spage>189</spage><epage>195</epage><pages>189-195</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background: As a test of possible muscarinic up-regulation, the cortisol response to intravenous (IV) physostigmine (an anticholinesterase) was measured in 9 elderly volunteers before and after chronic cholinergic blockade with the muscarinic cholinergic antagonist scopolamine.
Methods: Each of the 9 elderly control subjects was given two physostigmine (0.5 mg IV) infusions separated by 21 doses of nightly scopolamine (1.2 mg p.o.). No scopolamine was administered the night before infusions, and glycopyrrolate (0.2 mg IV) was administered prior to physostigmine to block its peripheral effects. Vital signs were monitored and blood samples were collected at six time points surrounding the physostigmine infusion (−10, +10, +20, +30, +50, and +70 min). Behavioral measures and cognitive tests were administered prior to and 30 min after the physostigmine.
Results: The cortisol response to physostigmine was greater after the second (post-chronic scopolamine) infusion study compared to the first (
p < .05) as measured by an area under the curve analysis of all time points. When individual time points were compared, the mean cortisol response was significantly increased after the second physostigmine infusion at the +50- and +70-min time points (
p < .05). There were no significant changes in behavioral rating scales, cognitive tests, or vital signs between the two physostigmine infusion study days.
Conclusions: This study demonstrates increased hypothalamic–pituitary–adrenocortical axis responsivity to a central nervous system cholinergic stimulus after chronic muscarinic blockade in 9 elderly control subjects. It also gives further evidence to support previous suggestions of muscarinic plasticity, specifically postsynaptic up-regulation, in the aging brain following exposure to chronic anticholinergic treatment.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10418693</pmid><doi>10.1016/S0006-3223(98)00286-8</doi><tpages>7</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0006-3223 |
ispartof | Biological psychiatry (1969), 1999-07, Vol.46 (2), p.189-195 |
issn | 0006-3223 1873-2402 |
language | eng |
recordid | cdi_proquest_miscellaneous_69915640 |
source | MEDLINE; Access via ScienceDirect (Elsevier) |
subjects | Aged Aging Aging - physiology Alzheimer’s Biological and medical sciences Brief Psychiatric Rating Scale Cholinesterase Inhibitors - pharmacology Cognition Disorders - diagnosis cortisol Depressive Disorder - diagnosis Depressive Disorder - psychology Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Glycopyrrolate - pharmacology Humans Hydrocortisone - blood Hypothalamo-Hypophyseal System - drug effects Injections, Intravenous Male Muscarinic Antagonists - pharmacology neuroendocrine Neuronal Plasticity - drug effects physostigmine Physostigmine - pharmacology Pituitary-Adrenal System - drug effects plasticity Presynaptic Terminals - drug effects Receptors, Muscarinic - drug effects scopolamine Scopolamine - pharmacology Severity of Illness Index Time Factors Up-Regulation - drug effects Vertebrates: nervous system and sense organs |
title | Physostigmine challenge before and after chronic cholinergic blockade in elderly volunteers |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T05%3A40%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physostigmine%20challenge%20before%20and%20after%20chronic%20cholinergic%20blockade%20in%20elderly%20volunteers&rft.jtitle=Biological%20psychiatry%20(1969)&rft.au=Dukoff,%20Ruth&rft.date=1999-07-15&rft.volume=46&rft.issue=2&rft.spage=189&rft.epage=195&rft.pages=189-195&rft.issn=0006-3223&rft.eissn=1873-2402&rft.coden=BIPCBF&rft_id=info:doi/10.1016/S0006-3223(98)00286-8&rft_dat=%3Cproquest_cross%3E69915640%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69915640&rft_id=info:pmid/10418693&rft_els_id=S0006322398002868&rfr_iscdi=true |