A Cross‐Talk Between Stromal Cell‐Derived Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin

Cell cycle regulation plays a fundamental role in stem cell biology. A balance between quiescence and proliferation of hematopoietic stem cells in interaction with the microenvironment is critical for sustaining long‐term hematopoiesis and for protection against stress. We analyzed the molecular mec...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2008-12, Vol.26 (12), p.3150-3161
Hauptverfasser:	Chabanon, Aurélie, Desterke, Christophe, Rodenburger, Emilie, Clay, Denis, Guerton, Bernadette, Boutin, Laetitia, Bennaceur‐Griscelli, Annelise, Pierre‐Louis, Olivier, Uzan, Georges, Abecassis, Lucile, Bourgeade, Marie‐Françoise, Lataillade, Jean‐Jacques, Le Bousse‐Kerdilès, Marie‐Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - biosynthesis CD34+ progenitors Cell Cycle Chemokine CXCL12 - metabolism Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FoxO3a Hematopoiesis Hematopoietic Stem Cells - cytology Humans Models, Biological mTOR Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein Kinases - metabolism Reverse Transcriptase Polymerase Chain Reaction SDF‐1 Signal Transduction Stem Cells - cytology TGF‐β TOR Serine-Threonine Kinases Transforming Growth Factor beta - metabolism
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