Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats
Lactation has been associated with anxiolysis in several tests of anxiety. These observations, considered together with observations that progesterone and its 5α-reduced metabolites are anxiolytic in cycling, nonlactating females, raised the question of whether the changes in anxiety-related behavio...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1999-07, Vol.63 (3), p.441-448 |
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| creator | Kellogg, Carol K Barrett, Kathy A |
| description | Lactation has been associated with anxiolysis in several tests of anxiety. These observations, considered together with observations that progesterone and its 5α-reduced metabolites are anxiolytic in cycling, nonlactating females, raised the question of whether the changes in anxiety-related behaviors that accompany lactation are driven by reduced progesterone metabolites. Lactating female rats were tested on the plus-maze on postpartum days 2 or 7, and demonstrated enhanced open-arm performance relative to cycling, nonlactating females. Hormonal analysis indicated that while serum levels of both progesterone and its 3α,5α-reduced metabolite were increased in lactating females, the turnover of progesterone to the metabolite was markedly reduced during lactation. Furthermore, treatment with a 5α-reductase inhibitor for 3 days prior to testing potentiated the open-arm performance in lactating females, implying that enhanced open-arm performance was not mediated by the reduction of progesterone or other steroids. Additionally, analysis of GABA
A receptor function indicated that parturition and lactation did not alter the sensitivity of the receptor to GABA or to modulation by reduced steroids. The mechanisms driving enhanced plus-maze behavior in lactating females appear to differ from mechanisms identified in nonlactating females. |
| doi_str_mv | 10.1016/S0091-3057(99)00041-6 |
| format | Article |
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A receptor function indicated that parturition and lactation did not alter the sensitivity of the receptor to GABA or to modulation by reduced steroids. The mechanisms driving enhanced plus-maze behavior in lactating females appear to differ from mechanisms identified in nonlactating females.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(99)00041-6</identifier><identifier>PMID: 10418786</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>5-alpha Reductase Inhibitors ; 5α-Reductase ; Adaptive behavior ; Aminoacid receptors (glycine, glutamate, gaba) ; Animals ; Anxiety ; Behavioral psychophysiology ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Cerebral Cortex - drug effects ; Cerebral Cortex - enzymology ; Cerebral Cortex - metabolism ; Enzyme Inhibitors - pharmacology ; Female ; Finasteride - analogs & derivatives ; Finasteride - pharmacology ; Fundamental and applied biological sciences. Psychology ; GABA A Receptors ; Hormones and behavior ; Lactation - drug effects ; Lactation - physiology ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Molecular and cellular biology ; Progesterone - blood ; Progesterone - metabolism ; Progesterone - physiology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Long-Evans ; Receptors, GABA-A - drug effects ; Vigilance</subject><ispartof>Pharmacology, biochemistry and behavior, 1999-07, Vol.63 (3), p.441-448</ispartof><rights>1999 Elsevier Science Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-1ad00dd058f6a962057d1db332e9ac901c764e79b6f4c351074af185e28dba7d3</citedby><cites>FETCH-LOGICAL-c468t-1ad00dd058f6a962057d1db332e9ac901c764e79b6f4c351074af185e28dba7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0091-3057(99)00041-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1881970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10418786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kellogg, Carol K</creatorcontrib><creatorcontrib>Barrett, Kathy A</creatorcontrib><title>Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Lactation has been associated with anxiolysis in several tests of anxiety. These observations, considered together with observations that progesterone and its 5α-reduced metabolites are anxiolytic in cycling, nonlactating females, raised the question of whether the changes in anxiety-related behaviors that accompany lactation are driven by reduced progesterone metabolites. Lactating female rats were tested on the plus-maze on postpartum days 2 or 7, and demonstrated enhanced open-arm performance relative to cycling, nonlactating females. Hormonal analysis indicated that while serum levels of both progesterone and its 3α,5α-reduced metabolite were increased in lactating females, the turnover of progesterone to the metabolite was markedly reduced during lactation. Furthermore, treatment with a 5α-reductase inhibitor for 3 days prior to testing potentiated the open-arm performance in lactating females, implying that enhanced open-arm performance was not mediated by the reduction of progesterone or other steroids. Additionally, analysis of GABA
A receptor function indicated that parturition and lactation did not alter the sensitivity of the receptor to GABA or to modulation by reduced steroids. The mechanisms driving enhanced plus-maze behavior in lactating females appear to differ from mechanisms identified in nonlactating females.</description><subject>5-alpha Reductase Inhibitors</subject><subject>5α-Reductase</subject><subject>Adaptive behavior</subject><subject>Aminoacid receptors (glycine, glutamate, gaba)</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - enzymology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Finasteride - analogs & derivatives</subject><subject>Finasteride - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA A Receptors</subject><subject>Hormones and behavior</subject><subject>Lactation - drug effects</subject><subject>Lactation - physiology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Maze Learning - physiology</subject><subject>Molecular and cellular biology</subject><subject>Progesterone - blood</subject><subject>Progesterone - metabolism</subject><subject>Progesterone - physiology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Receptors, GABA-A - drug effects</subject><subject>Vigilance</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhkOptNvqT1ByUaS9GM2Zj3xcSVnaKmx1qXodMsmZEpnZ1CQj6K9vtruod70KhOck73leQl4DewcM-PuvjCmoGtaJc6UuGGMtVPyALECKpupAiEOy-Isck5OUfmyhmosjcgyFlkLyBXF36GaLjq5juMeUMYYN0lvMpg-jz5joZUT6OWS6jD57a0Y6hEjX45yqW_MH6RpjuZjMxiINA10Zm032m3t6jZMZkd6ZnF6SF4MZE77an6fk-_XVt-XHavXl5tPyclXZlstcgXGMOcc6OXCjeF2CO3B909SojFUMrOAtCtXzobVNB0y0ZgDZYS1db4RrTsnb3bsPMfycyzZ68sniOJoNhjlprhQ0qmXPgiA6VoNSBex2oI0hpYiDfoh-MvG3Bqa3PeinHvRWslZKP_WgeZl7s_9g7id0_03txBfgbA-YVKQOsQj06R8nJSixDfphh2HR9stj1Ml6LK6dj2izdsE_k-QRG0yj2w</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Kellogg, Carol K</creator><creator>Barrett, Kathy A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats</title><author>Kellogg, Carol K ; Barrett, Kathy A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-1ad00dd058f6a962057d1db332e9ac901c764e79b6f4c351074af185e28dba7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>5-alpha Reductase Inhibitors</topic><topic>5α-Reductase</topic><topic>Adaptive behavior</topic><topic>Aminoacid receptors (glycine, glutamate, gaba)</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - enzymology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Finasteride - analogs & derivatives</topic><topic>Finasteride - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA A Receptors</topic><topic>Hormones and behavior</topic><topic>Lactation - drug effects</topic><topic>Lactation - physiology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Maze Learning - physiology</topic><topic>Molecular and cellular biology</topic><topic>Progesterone - blood</topic><topic>Progesterone - metabolism</topic><topic>Progesterone - physiology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Receptors, GABA-A - drug effects</topic><topic>Vigilance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kellogg, Carol K</creatorcontrib><creatorcontrib>Barrett, Kathy A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kellogg, Carol K</au><au>Barrett, Kathy A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>63</volume><issue>3</issue><spage>441</spage><epage>448</epage><pages>441-448</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Lactation has been associated with anxiolysis in several tests of anxiety. These observations, considered together with observations that progesterone and its 5α-reduced metabolites are anxiolytic in cycling, nonlactating females, raised the question of whether the changes in anxiety-related behaviors that accompany lactation are driven by reduced progesterone metabolites. Lactating female rats were tested on the plus-maze on postpartum days 2 or 7, and demonstrated enhanced open-arm performance relative to cycling, nonlactating females. Hormonal analysis indicated that while serum levels of both progesterone and its 3α,5α-reduced metabolite were increased in lactating females, the turnover of progesterone to the metabolite was markedly reduced during lactation. Furthermore, treatment with a 5α-reductase inhibitor for 3 days prior to testing potentiated the open-arm performance in lactating females, implying that enhanced open-arm performance was not mediated by the reduction of progesterone or other steroids. Additionally, analysis of GABA
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| subjects | 5-alpha Reductase Inhibitors 5α-Reductase Adaptive behavior Aminoacid receptors (glycine, glutamate, gaba) Animals Anxiety Behavioral psychophysiology Biological and medical sciences Cell receptors Cell structures and functions Cerebral Cortex - drug effects Cerebral Cortex - enzymology Cerebral Cortex - metabolism Enzyme Inhibitors - pharmacology Female Finasteride - analogs & derivatives Finasteride - pharmacology Fundamental and applied biological sciences. Psychology GABA A Receptors Hormones and behavior Lactation - drug effects Lactation - physiology Male Maze Learning - drug effects Maze Learning - physiology Molecular and cellular biology Progesterone - blood Progesterone - metabolism Progesterone - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Long-Evans Receptors, GABA-A - drug effects Vigilance |
| title | Reduced Progesterone Metabolites Are Not Critical for Plus-Maze Performance of Lactating Female Rats |
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