Safety and immunogenicity of live attenuated human–bovine (UK) reassortant rotavirus vaccines with VP7-specificity for serotypes 1, 2, 3 or 4 in adults, children and infants

Live rotavirus vaccine candidates representing VP7 serotypes 1, 2, 3 or 4 derived by reassortment between bovine UK rotavirus and human rotavirus strains D, DS-1, P or ST3 were evaluated for safety and immunogenicity in adults, children and infants. Infection was defined by evidence of rotavirus she...

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Veröffentlicht in:	Vaccine 1999-06, Vol.17 (20), p.2715-2725
Hauptverfasser:	Clements-Mann, Mary Lou, Makhene, Mamodikoe K, Mrukowicz, Jacek, Wright, Peter F, Hoshino, Yasutaka, Midthun, Karen, Sperber, Ellen, Karron, Ruth, Kapikian, Albert Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alanine Transaminase - blood Animals Antibodies, Viral - blood Antigens, Viral Biological and medical sciences Capsid - immunology Capsid Proteins Cattle Child, Preschool Diarrheal vaccines Epidemiology. Vaccinations Fundamental and applied biological sciences. Psychology General aspects Humans Human–bovine reassortant rotavirus vaccines Immunization, Secondary Infant Infectious diseases Live attenuated virus vaccines Medical sciences Microbiology Middle Aged Pediatric vaccines Rotavirus - immunology Rotavirus vaccines Serotyping Vaccination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology Vaccines, Synthetic - immunology Viral Vaccines - adverse effects Viral Vaccines - immunology Virology
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