Intratumoural heterogeneity of intestinal expression reflects environmental induction and progression-related loss of induction in undifferentiated-type gastric carcinomas

Aims: Gene expression in tumours is regulated by environmental as well as genetic/epigenetic factors. This study assessed the environmental factors in intestinal expression of gastric cancers. Methods and results: We immunohistochemically examined intratumoural heterogeneity in the expression of C...

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Veröffentlicht in:	Histopathology 2008-12, Vol.53 (6), p.685-697
Hauptverfasser:	Natsagdorj, L, Sugihara, H, Bamba, M, Hattori, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Carcinoma - metabolism Carcinoma - pathology Cdx2 CDX2 Transcription Factor Cell Differentiation Environment Gastric Mucosa - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Immunohistochemistry Intestinal Mucosa - metabolism Intestines - pathology Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged MUC2 Mucin 5AC - genetics Mucin 5AC - metabolism Mucin-2 - genetics Mucin-2 - metabolism Mucin-6 - genetics Mucin-6 - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Stomach - pathology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus tissue environment Tumors tumour progression undifferentiated-type gastric carcinoma
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