Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice
The influence of antigenic forms of Aujeszky's disease virus (ADV) and adjuvant types on the production of IgG subclass antibodies in mice was investigated. Particulate antigen, inactivated ADV, alone induced IgG1 and lower IgG2a antibody production, while the antigen adsorbed onto aluminum pho...
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| Veröffentlicht in: | Vaccine 1999-06, Vol.17 (20), p.2733-2739 |
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| creator | Katayama, Shigeji Oda, Kenji Ohgitani, Toshiaki Hirahara, Tadashi Shimizu, Yukio |
| description | The influence of antigenic forms of Aujeszky's disease virus (ADV) and adjuvant types on the production of IgG subclass antibodies in mice was investigated. Particulate antigen, inactivated ADV, alone induced IgG1 and lower IgG2a antibody production, while the antigen adsorbed onto aluminum phosphate gel (alum) enhanced IgG1 antibody production but suppressed IgG2a antibody production as well as solubilized ADV antigen adsorbed onto alum. QS21 saponin purified from
Quillaja saponaria promoted the production of IgG1 and IgG2a antibodies in a large extent against the both particulate and soluble antigens, while this saponin has strong hemolytic activity. Lablaboside F saponin isolated from
Dolichos lablab without hemolytic activity, also induced the production of large IgG1 and little IgG2a antibody against both antigens. Oil-based adjuvant, ISA70 of water-in-oil type and ISA25 of oil-in-water type, increased IgG1 and IgG2a antibodies against the both soluble and particulate antigens, whereas a combination of ISA25 and soluble antigen reduced IgG2a antibody response. These results indicate that IgG1 antibody production was not suppressed by a combination of antigenic form and adjuvant type, however, IgG2a antibody production was influenced. |
| doi_str_mv | 10.1016/S0264-410X(98)00499-X |
| format | Article |
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Quillaja saponaria promoted the production of IgG1 and IgG2a antibodies in a large extent against the both particulate and soluble antigens, while this saponin has strong hemolytic activity. Lablaboside F saponin isolated from
Dolichos lablab without hemolytic activity, also induced the production of large IgG1 and little IgG2a antibody against both antigens. Oil-based adjuvant, ISA70 of water-in-oil type and ISA25 of oil-in-water type, increased IgG1 and IgG2a antibodies against the both soluble and particulate antigens, whereas a combination of ISA25 and soluble antigen reduced IgG2a antibody response. These results indicate that IgG1 antibody production was not suppressed by a combination of antigenic form and adjuvant type, however, IgG2a antibody production was influenced.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(98)00499-X</identifier><identifier>PMID: 10418925</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Alum Compounds - administration & dosage ; Aluminum gel ; Animals ; Antibodies, Viral - blood ; Antigens, Viral - administration & dosage ; Antigens, Viral - immunology ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Herpesvirus 1, Suid - immunology ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Lablaboside F saponin ; Mice ; Mice, Inbred BALB C ; Microbiology ; Oil-based adjuvant ; Particulate antigen ; Saponins - administration & dosage ; Soluble antigen ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology</subject><ispartof>Vaccine, 1999-06, Vol.17 (20), p.2733-2739</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-978592735d6d718b2513076c9ce9b75c0d38188f623b2a7f6c5e58f9efb5f1c63</citedby><cites>FETCH-LOGICAL-c390t-978592735d6d718b2513076c9ce9b75c0d38188f623b2a7f6c5e58f9efb5f1c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(98)00499-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1876974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10418925$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katayama, Shigeji</creatorcontrib><creatorcontrib>Oda, Kenji</creatorcontrib><creatorcontrib>Ohgitani, Toshiaki</creatorcontrib><creatorcontrib>Hirahara, Tadashi</creatorcontrib><creatorcontrib>Shimizu, Yukio</creatorcontrib><title>Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The influence of antigenic forms of Aujeszky's disease virus (ADV) and adjuvant types on the production of IgG subclass antibodies in mice was investigated. Particulate antigen, inactivated ADV, alone induced IgG1 and lower IgG2a antibody production, while the antigen adsorbed onto aluminum phosphate gel (alum) enhanced IgG1 antibody production but suppressed IgG2a antibody production as well as solubilized ADV antigen adsorbed onto alum. QS21 saponin purified from
Quillaja saponaria promoted the production of IgG1 and IgG2a antibodies in a large extent against the both particulate and soluble antigens, while this saponin has strong hemolytic activity. Lablaboside F saponin isolated from
Dolichos lablab without hemolytic activity, also induced the production of large IgG1 and little IgG2a antibody against both antigens. Oil-based adjuvant, ISA70 of water-in-oil type and ISA25 of oil-in-water type, increased IgG1 and IgG2a antibodies against the both soluble and particulate antigens, whereas a combination of ISA25 and soluble antigen reduced IgG2a antibody response. These results indicate that IgG1 antibody production was not suppressed by a combination of antigenic form and adjuvant type, however, IgG2a antibody production was influenced.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Alum Compounds - administration & dosage</subject><subject>Aluminum gel</subject><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens, Viral - administration & dosage</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpesvirus 1, Suid - immunology</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Lablaboside F saponin</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Oil-based adjuvant</subject><subject>Particulate antigen</subject><subject>Saponins - administration & dosage</subject><subject>Soluble antigen</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhJ4B8QHwcAnYSO_YJVRWUlSr1AEh7sxx7XLwk8daTrLT8-mY_BL31ZI39vB7PY0Jec_aJMy4__2ClrIuas9UHrT4yVmtdrJ6QBVdNVZSCq6dk8Q85Iy8Q14wxUXH9nJxxVnOlS7Eg43II3QSDA5oCtcMYb2GIjoaUe5xrT61fT9v5AGka6Pgb6PL2iuLUus4iHhJt8juaATdpQKBjohfTGvDvn917pD4i2Hl3G_OENA60jw5ekmfBdgivTus5-fXt68_L78X1zdXy8uK6cJVmY6EbJXTZVMJL33DVzlNVrJFOO9BtIxzzleJKBVlWbWmbIJ0AoYKG0IrAnazOybvjvZuc7ibA0fQRHXSdHSBNaKTWnNeSzaA4gi4nxAzBbHLsbd4ZzsxetznoNnuXRitz0G1Wc-7NqcHU9uAfpI5-Z-DtCbDobBeyHVzE_5xqpG7qGftyxGC2sY2QDbq4_xQfM7jR-BQfeck90TidvA</recordid><startdate>19990604</startdate><enddate>19990604</enddate><creator>Katayama, Shigeji</creator><creator>Oda, Kenji</creator><creator>Ohgitani, Toshiaki</creator><creator>Hirahara, Tadashi</creator><creator>Shimizu, Yukio</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990604</creationdate><title>Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice</title><author>Katayama, Shigeji ; Oda, Kenji ; Ohgitani, Toshiaki ; Hirahara, Tadashi ; Shimizu, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-978592735d6d718b2513076c9ce9b75c0d38188f623b2a7f6c5e58f9efb5f1c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Alum Compounds - administration & dosage</topic><topic>Aluminum gel</topic><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Antigens, Viral - administration & dosage</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpesvirus 1, Suid - immunology</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Lablaboside F saponin</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Oil-based adjuvant</topic><topic>Particulate antigen</topic><topic>Saponins - administration & dosage</topic><topic>Soluble antigen</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katayama, Shigeji</creatorcontrib><creatorcontrib>Oda, Kenji</creatorcontrib><creatorcontrib>Ohgitani, Toshiaki</creatorcontrib><creatorcontrib>Hirahara, Tadashi</creatorcontrib><creatorcontrib>Shimizu, Yukio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katayama, Shigeji</au><au>Oda, Kenji</au><au>Ohgitani, Toshiaki</au><au>Hirahara, Tadashi</au><au>Shimizu, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1999-06-04</date><risdate>1999</risdate><volume>17</volume><issue>20</issue><spage>2733</spage><epage>2739</epage><pages>2733-2739</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The influence of antigenic forms of Aujeszky's disease virus (ADV) and adjuvant types on the production of IgG subclass antibodies in mice was investigated. Particulate antigen, inactivated ADV, alone induced IgG1 and lower IgG2a antibody production, while the antigen adsorbed onto aluminum phosphate gel (alum) enhanced IgG1 antibody production but suppressed IgG2a antibody production as well as solubilized ADV antigen adsorbed onto alum. QS21 saponin purified from
Quillaja saponaria promoted the production of IgG1 and IgG2a antibodies in a large extent against the both particulate and soluble antigens, while this saponin has strong hemolytic activity. Lablaboside F saponin isolated from
Dolichos lablab without hemolytic activity, also induced the production of large IgG1 and little IgG2a antibody against both antigens. Oil-based adjuvant, ISA70 of water-in-oil type and ISA25 of oil-in-water type, increased IgG1 and IgG2a antibodies against the both soluble and particulate antigens, whereas a combination of ISA25 and soluble antigen reduced IgG2a antibody response. These results indicate that IgG1 antibody production was not suppressed by a combination of antigenic form and adjuvant type, however, IgG2a antibody production was influenced.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10418925</pmid><doi>10.1016/S0264-410X(98)00499-X</doi><tpages>7</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - administration & dosage Alum Compounds - administration & dosage Aluminum gel Animals Antibodies, Viral - blood Antigens, Viral - administration & dosage Antigens, Viral - immunology Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Herpesvirus 1, Suid - immunology Immunoglobulin G - blood Immunoglobulin G - classification Lablaboside F saponin Mice Mice, Inbred BALB C Microbiology Oil-based adjuvant Particulate antigen Saponins - administration & dosage Soluble antigen Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology |
| title | Influence of antigenic forms and adjuvants on the IgG subclass antibody response to Aujeszky's disease virus in mice |
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