IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-α in human articular chondrocytes in vitro

Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-α in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cart...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2008-12, Vol.44 (3), p.377-385
Hauptverfasser:	Müller, R.D., John, T., Kohl, B., Oberholzer, A., Gust, T., Hostmann, A., Hellmuth, M., LaFace, D., Hutchins, B., Laube, G., Veh, R.W., Tschoeke, S.K., Ertel, W., Schulze-Tanzil, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Adenovirus Aged Aged, 80 and over Arteries - metabolism Cartilage Oligomeric Matrix Protein Cells, Cultured Chondrocytes Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - ultrastructure Collagen Type II - genetics Collagen Type II - metabolism Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Genetic Vectors - genetics Glycoproteins - genetics Glycoproteins - metabolism Humans IL-10 Interleukin-10 - genetics Interleukin-10 - metabolism Matrilin Proteins Matrix Metalloproteinase 13 - genetics Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism Microscopy, Electron, Transmission Middle Aged RNA, Messenger - genetics TNF-α Tumor Necrosis Factor-alpha
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