Interferon-alpha in viral and bacterial gastroenteritis : a comparison with C-reactive protein and interleukin-6
The aim of the study was to identify serum markers able to differentiate bacterial and viral origin in acute diarrhoea. Interferon-alpha (INF-alpha), C-reactive protein (CRP) and interleukin-6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized f...
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| Veröffentlicht in: | Acta pædiatrica (Oslo) 1999-06, Vol.88 (6), p.592-594 |
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| container_title | Acta pædiatrica (Oslo) |
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| creator | MANGIAROTTI, P MOULIN, F PALMER, P RAVILLY, S RAYMOND, J GENDREL, D |
| description | The aim of the study was to identify serum markers able to differentiate bacterial and viral origin in acute diarrhoea. Interferon-alpha (INF-alpha), C-reactive protein (CRP) and interleukin-6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized for rotavirus (n = 60) or bacterial diarrhoea (Salmonella spp. 39 cases, Shigella spp. 15 cases, Campylobacter jejuni 5 cases). CRP concentration was >10 mg/l in 48.3% of children with viral gastroenteritis and 86.4% of children with bacterial gastroenteritis. IL6 concentration was >100 pg/ml in 11.7% and 26.3% of cases, respectively. INF-alpha was detected in 79.1% of children with rotavirus (sens 79%) and in 3.5% (spec 93%) with bacterial gastroenteritis. However the INF-alpha assay takes 48 h and pathogens are often identified from stools before interferon results are available. We found that serum markers are not discriminating enough to differentiate between viral and bacterial gastroenteritis in emergency cases. |
| doi_str_mv | 10.1080/08035259950169206 |
| format | Article |
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Interferon-alpha (INF-alpha), C-reactive protein (CRP) and interleukin-6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized for rotavirus (n = 60) or bacterial diarrhoea (Salmonella spp. 39 cases, Shigella spp. 15 cases, Campylobacter jejuni 5 cases). CRP concentration was >10 mg/l in 48.3% of children with viral gastroenteritis and 86.4% of children with bacterial gastroenteritis. IL6 concentration was >100 pg/ml in 11.7% and 26.3% of cases, respectively. INF-alpha was detected in 79.1% of children with rotavirus (sens 79%) and in 3.5% (spec 93%) with bacterial gastroenteritis. However the INF-alpha assay takes 48 h and pathogens are often identified from stools before interferon results are available. We found that serum markers are not discriminating enough to differentiate between viral and bacterial gastroenteritis in emergency cases.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1080/08035259950169206</identifier><identifier>PMID: 10419239</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Acute Disease ; Bacterial Infections - complications ; Biological and medical sciences ; Biomarkers - blood ; C-Reactive Protein - analysis ; Child, Preschool ; Diagnosis, Differential ; Diarrhea - microbiology ; Digestive system ; Feces - microbiology ; Female ; Gastroenteritis - blood ; Gastroenteritis - diagnosis ; Gastroenteritis - microbiology ; Humans ; Infant ; Infant, Newborn ; Interferon-alpha - blood ; Interleukin-6 - blood ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Retrospective Studies ; Rotavirus Infections - virology</subject><ispartof>Acta pædiatrica (Oslo), 1999-06, Vol.88 (6), p.592-594</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c284t-1659afc2f61dacea102932c84ba532b3e7fa6f741418ee280e41ef7ee6095c753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1847343$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10419239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MANGIAROTTI, P</creatorcontrib><creatorcontrib>MOULIN, F</creatorcontrib><creatorcontrib>PALMER, P</creatorcontrib><creatorcontrib>RAVILLY, S</creatorcontrib><creatorcontrib>RAYMOND, J</creatorcontrib><creatorcontrib>GENDREL, D</creatorcontrib><title>Interferon-alpha in viral and bacterial gastroenteritis : a comparison with C-reactive protein and interleukin-6</title><title>Acta pædiatrica (Oslo)</title><addtitle>Acta Paediatr</addtitle><description>The aim of the study was to identify serum markers able to differentiate bacterial and viral origin in acute diarrhoea. Interferon-alpha (INF-alpha), C-reactive protein (CRP) and interleukin-6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized for rotavirus (n = 60) or bacterial diarrhoea (Salmonella spp. 39 cases, Shigella spp. 15 cases, Campylobacter jejuni 5 cases). CRP concentration was >10 mg/l in 48.3% of children with viral gastroenteritis and 86.4% of children with bacterial gastroenteritis. IL6 concentration was >100 pg/ml in 11.7% and 26.3% of cases, respectively. INF-alpha was detected in 79.1% of children with rotavirus (sens 79%) and in 3.5% (spec 93%) with bacterial gastroenteritis. However the INF-alpha assay takes 48 h and pathogens are often identified from stools before interferon results are available. We found that serum markers are not discriminating enough to differentiate between viral and bacterial gastroenteritis in emergency cases.</description><subject>Acute Disease</subject><subject>Bacterial Infections - complications</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Child, Preschool</subject><subject>Diagnosis, Differential</subject><subject>Diarrhea - microbiology</subject><subject>Digestive system</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Gastroenteritis - blood</subject><subject>Gastroenteritis - diagnosis</subject><subject>Gastroenteritis - microbiology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Interferon-alpha - blood</subject><subject>Interleukin-6 - blood</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Retrospective Studies</subject><subject>Rotavirus Infections - virology</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqXwAWyQF4hdwK84MTtU8ahUiQ2so4k7oYa8sJMi_h5HFLEYjUb33KuZIeScs2vOcnYTS6YiNSZlXBvB9AGZc53yRAiRHZL5pCcRkDNyEsI7Y0zJTB2TGWeKGyHNnPSrdkBfoe_aBOp-C9S1dOc81BTaDS3BRtnF6Q3C4DucaDe4QG8pUNs1PXgXupZ-uWFLl4nHaHA7pL3vBoxRU4ibTDWOH65N9Ck5qqAOeLbvC_L6cP-yfErWz4-r5d06sSJXQxLPMFBZUWm-AYvAmTBS2FyVkEpRSswq0FWmuOI5osgZKo5VhqiZSW2WygW5-s2Nm3yOGIaiccFiXUOL3RgKbQxnmdYRvNiDY9ngpui9a8B_F38_isDlHoBgoa48tNaFfy5XmVRS_gAidnbv</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>MANGIAROTTI, P</creator><creator>MOULIN, F</creator><creator>PALMER, P</creator><creator>RAVILLY, S</creator><creator>RAYMOND, J</creator><creator>GENDREL, D</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Interferon-alpha in viral and bacterial gastroenteritis : a comparison with C-reactive protein and interleukin-6</title><author>MANGIAROTTI, P ; MOULIN, F ; PALMER, P ; RAVILLY, S ; RAYMOND, J ; GENDREL, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-1659afc2f61dacea102932c84ba532b3e7fa6f741418ee280e41ef7ee6095c753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acute Disease</topic><topic>Bacterial Infections - complications</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Child, Preschool</topic><topic>Diagnosis, Differential</topic><topic>Diarrhea - microbiology</topic><topic>Digestive system</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Gastroenteritis - blood</topic><topic>Gastroenteritis - diagnosis</topic><topic>Gastroenteritis - microbiology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Interferon-alpha - blood</topic><topic>Interleukin-6 - blood</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Retrospective Studies</topic><topic>Rotavirus Infections - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MANGIAROTTI, P</creatorcontrib><creatorcontrib>MOULIN, F</creatorcontrib><creatorcontrib>PALMER, P</creatorcontrib><creatorcontrib>RAVILLY, S</creatorcontrib><creatorcontrib>RAYMOND, J</creatorcontrib><creatorcontrib>GENDREL, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta pædiatrica (Oslo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MANGIAROTTI, P</au><au>MOULIN, F</au><au>PALMER, P</au><au>RAVILLY, S</au><au>RAYMOND, J</au><au>GENDREL, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interferon-alpha in viral and bacterial gastroenteritis : a comparison with C-reactive protein and interleukin-6</atitle><jtitle>Acta pædiatrica (Oslo)</jtitle><addtitle>Acta Paediatr</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>88</volume><issue>6</issue><spage>592</spage><epage>594</epage><pages>592-594</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>The aim of the study was to identify serum markers able to differentiate bacterial and viral origin in acute diarrhoea. Interferon-alpha (INF-alpha), C-reactive protein (CRP) and interleukin-6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized for rotavirus (n = 60) or bacterial diarrhoea (Salmonella spp. 39 cases, Shigella spp. 15 cases, Campylobacter jejuni 5 cases). CRP concentration was >10 mg/l in 48.3% of children with viral gastroenteritis and 86.4% of children with bacterial gastroenteritis. IL6 concentration was >100 pg/ml in 11.7% and 26.3% of cases, respectively. INF-alpha was detected in 79.1% of children with rotavirus (sens 79%) and in 3.5% (spec 93%) with bacterial gastroenteritis. However the INF-alpha assay takes 48 h and pathogens are often identified from stools before interferon results are available. We found that serum markers are not discriminating enough to differentiate between viral and bacterial gastroenteritis in emergency cases.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>10419239</pmid><doi>10.1080/08035259950169206</doi><tpages>3</tpages></addata></record> |
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| subjects | Acute Disease Bacterial Infections - complications Biological and medical sciences Biomarkers - blood C-Reactive Protein - analysis Child, Preschool Diagnosis, Differential Diarrhea - microbiology Digestive system Feces - microbiology Female Gastroenteritis - blood Gastroenteritis - diagnosis Gastroenteritis - microbiology Humans Infant Infant, Newborn Interferon-alpha - blood Interleukin-6 - blood Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retrospective Studies Rotavirus Infections - virology |
| title | Interferon-alpha in viral and bacterial gastroenteritis : a comparison with C-reactive protein and interleukin-6 |
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