Modulation of acetylcholine release from parasympathetic nerves innervating guinea-pig and human trachea by endomorphin-1 and -2

Endomorphin-1 and -2 (μ-opioid receptor agonists) produced a concentration-dependent and naloxone-sensitive inhibition of cholinergic contractile responses in guinea-pig trachea (at 10 μM, 46.1±8.0% and 33.8±8.6%, respectively). Endomorphin-1 and -2 also inhibited electrically-evoked acetylcholine r...

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Veröffentlicht in:	European journal of pharmacology 1999-06, Vol.374 (1), p.21-24
Hauptverfasser:	Patel, Hema J, Venkatesan, Priya, Halfpenny, James, Yacoub, Magdi H, Fox, Alyson, Barnes, Peter J, Belvisi, Maria G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - metabolism Airway Animals Biological and medical sciences Cholinergic neurotransmission Dose-Response Relationship, Drug Endomorphin-1 Endomorphin-2 Fundamental and applied biological sciences. Psychology Guinea Pigs Humans Male Muscle Contraction - drug effects Naloxone - pharmacology Oligopeptides - pharmacology Opioid receptor Parasympathetic Nervous System - drug effects Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Receptors, Opioid, mu - agonists Trachea - drug effects Trachea - innervation Trachea - physiology Vertebrates: nervous system and sense organs
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