Diagnostic usefulness of N-terminal brain natriuretic peptide in patients admitted to a cardiology service
The N-terminal brain natriuretic peptide (NT-proBNP) is a new tool for the diagnosis of patients with evidence of heart failure (HF). The diagnosis of HF is improbable in patients with a level of NT-proBNP
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| Veröffentlicht in: | Medicina clínica 2008-11, Vol.131 (19), p.737-738 |
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| container_issue | 19 |
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| container_title | Medicina clínica |
| container_volume | 131 |
| creator | Farráis Villalba, Marcos Rodríguez Esteban, Marcos de las Heras, Silvia Facenda Lorenzo, María Ramos López, María Soriano Vela, Estanislao |
| description | The N-terminal brain natriuretic peptide (NT-proBNP) is a new tool for the diagnosis of patients with evidence of heart failure (HF). The diagnosis of HF is improbable in patients with a level of NT-proBNP |
| doi_str_mv | 10.1016/S0025-7753(08)75488-5 |
| format | Article |
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We gathered consecutively the data of 76 patients admitted to our service with the diagnosis of HF (n=37) and with other diseases (n=39), taking a sample of plasma to determine NT-proBNP. We studied the sensitivity, specificity and predictive values of this test, as well as the relation between the levels of that marker and the clinical and echocardiographic variables.
The ventricular diameter was larger and the ejection fraction was lower in patients with HF. Sensitivity for the diagnosis of exclusion reached a value of 97% and the negative predictive value was 94%.
The cut-off point proposed for exclusion (300 pg/ml) shows high sensitivity and negative predictive value in the diagnosis of HF in patients admitted to our service.</description><identifier>ISSN: 0025-7753</identifier><identifier>DOI: 10.1016/S0025-7753(08)75488-5</identifier><identifier>PMID: 19091201</identifier><language>spa</language><publisher>Spain</publisher><subject>Acute Disease ; Aged ; Biomarkers ; Cardiology - statistics & numerical data ; Female ; Heart Diseases - blood ; Heart Diseases - epidemiology ; Heart Diseases - rehabilitation ; Heart Failure - blood ; Heart Failure - epidemiology ; Heart Failure - rehabilitation ; Hospitalization - statistics & numerical data ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Patient Admission - statistics & numerical data ; Peptide Fragments - blood ; Prospective Studies</subject><ispartof>Medicina clínica, 2008-11, Vol.131 (19), p.737-738</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19091201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farráis Villalba, Marcos</creatorcontrib><creatorcontrib>Rodríguez Esteban, Marcos</creatorcontrib><creatorcontrib>de las Heras, Silvia</creatorcontrib><creatorcontrib>Facenda Lorenzo, María</creatorcontrib><creatorcontrib>Ramos López, María</creatorcontrib><creatorcontrib>Soriano Vela, Estanislao</creatorcontrib><title>Diagnostic usefulness of N-terminal brain natriuretic peptide in patients admitted to a cardiology service</title><title>Medicina clínica</title><addtitle>Med Clin (Barc)</addtitle><description>The N-terminal brain natriuretic peptide (NT-proBNP) is a new tool for the diagnosis of patients with evidence of heart failure (HF). The diagnosis of HF is improbable in patients with a level of NT-proBNP<300 pg/ml. Our objective is to determine the validity of the cut-off points proposed by literature (inclusion/exclusion) regarding the age for NT-proBNP in patients admitted to our service.
We gathered consecutively the data of 76 patients admitted to our service with the diagnosis of HF (n=37) and with other diseases (n=39), taking a sample of plasma to determine NT-proBNP. We studied the sensitivity, specificity and predictive values of this test, as well as the relation between the levels of that marker and the clinical and echocardiographic variables.
The ventricular diameter was larger and the ejection fraction was lower in patients with HF. Sensitivity for the diagnosis of exclusion reached a value of 97% and the negative predictive value was 94%.
The cut-off point proposed for exclusion (300 pg/ml) shows high sensitivity and negative predictive value in the diagnosis of HF in patients admitted to our service.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>Biomarkers</subject><subject>Cardiology - statistics & numerical data</subject><subject>Female</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - epidemiology</subject><subject>Heart Diseases - rehabilitation</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - epidemiology</subject><subject>Heart Failure - rehabilitation</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Patient Admission - statistics & numerical data</subject><subject>Peptide Fragments - blood</subject><subject>Prospective Studies</subject><issn>0025-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLtOAzEURF2ASAh8AsgVgmLBD7xelyg8pQgKoF7d2NeRo31he5Hy9yQiUI3m6GiKIeSMs2vOeHnzzphQhdZKXrLqSqvbqirUAZn-4wk5Tmm9q5LrIzLhhhkuGJ-S9X2AVdenHCwdE_qx6TAl2nv6WmSMbeigocsIoaMd5BjGiDt1wCEHh3SLB8gBu5wouDbkjI7mngK1EF3om361oQnjd7B4Qg49NAlP9zkjn48PH_PnYvH29DK_WxQDlyYXAMYaK61yYLXwHLwooVqWRhqzRIfe20ppXwnhBHqhSi05lCCZBuY893JGLn53h9h_jZhy3YZksWmgw35MdWkMZ6piW_F8L47LFl09xNBC3NR_78gftu1o0Q</recordid><startdate>20081129</startdate><enddate>20081129</enddate><creator>Farráis Villalba, Marcos</creator><creator>Rodríguez Esteban, Marcos</creator><creator>de las Heras, Silvia</creator><creator>Facenda Lorenzo, María</creator><creator>Ramos López, María</creator><creator>Soriano Vela, Estanislao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20081129</creationdate><title>Diagnostic usefulness of N-terminal brain natriuretic peptide in patients admitted to a cardiology service</title><author>Farráis Villalba, Marcos ; Rodríguez Esteban, Marcos ; de las Heras, Silvia ; Facenda Lorenzo, María ; Ramos López, María ; Soriano Vela, Estanislao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-aa9c9c3c5dac72f1af26a8b69399bedeffc857f822d2ef256731a6a307a0df1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2008</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>Biomarkers</topic><topic>Cardiology - statistics & numerical data</topic><topic>Female</topic><topic>Heart Diseases - blood</topic><topic>Heart Diseases - epidemiology</topic><topic>Heart Diseases - rehabilitation</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - epidemiology</topic><topic>Heart Failure - rehabilitation</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Patient Admission - statistics & numerical data</topic><topic>Peptide Fragments - blood</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farráis Villalba, Marcos</creatorcontrib><creatorcontrib>Rodríguez Esteban, Marcos</creatorcontrib><creatorcontrib>de las Heras, Silvia</creatorcontrib><creatorcontrib>Facenda Lorenzo, María</creatorcontrib><creatorcontrib>Ramos López, María</creatorcontrib><creatorcontrib>Soriano Vela, Estanislao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Medicina clínica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farráis Villalba, Marcos</au><au>Rodríguez Esteban, Marcos</au><au>de las Heras, Silvia</au><au>Facenda Lorenzo, María</au><au>Ramos López, María</au><au>Soriano Vela, Estanislao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic usefulness of N-terminal brain natriuretic peptide in patients admitted to a cardiology service</atitle><jtitle>Medicina clínica</jtitle><addtitle>Med Clin (Barc)</addtitle><date>2008-11-29</date><risdate>2008</risdate><volume>131</volume><issue>19</issue><spage>737</spage><epage>738</epage><pages>737-738</pages><issn>0025-7753</issn><abstract>The N-terminal brain natriuretic peptide (NT-proBNP) is a new tool for the diagnosis of patients with evidence of heart failure (HF). The diagnosis of HF is improbable in patients with a level of NT-proBNP<300 pg/ml. Our objective is to determine the validity of the cut-off points proposed by literature (inclusion/exclusion) regarding the age for NT-proBNP in patients admitted to our service.
We gathered consecutively the data of 76 patients admitted to our service with the diagnosis of HF (n=37) and with other diseases (n=39), taking a sample of plasma to determine NT-proBNP. We studied the sensitivity, specificity and predictive values of this test, as well as the relation between the levels of that marker and the clinical and echocardiographic variables.
The ventricular diameter was larger and the ejection fraction was lower in patients with HF. Sensitivity for the diagnosis of exclusion reached a value of 97% and the negative predictive value was 94%.
The cut-off point proposed for exclusion (300 pg/ml) shows high sensitivity and negative predictive value in the diagnosis of HF in patients admitted to our service.</abstract><cop>Spain</cop><pmid>19091201</pmid><doi>10.1016/S0025-7753(08)75488-5</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acute Disease Aged Biomarkers Cardiology - statistics & numerical data Female Heart Diseases - blood Heart Diseases - epidemiology Heart Diseases - rehabilitation Heart Failure - blood Heart Failure - epidemiology Heart Failure - rehabilitation Hospitalization - statistics & numerical data Humans Male Middle Aged Natriuretic Peptide, Brain - blood Patient Admission - statistics & numerical data Peptide Fragments - blood Prospective Studies |
| title | Diagnostic usefulness of N-terminal brain natriuretic peptide in patients admitted to a cardiology service |
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