Clopidogrel Attenuates Coated-platelet Production in Patients Undergoing Elective Coronary Catheterization

INTRODUCTION:Coated-platelets are a subclass of highly thrombotic activated platelets with an enhanced ability to generate thrombin. Excessive numbers of coated-platelets are believed to increase thrombotic risk. A previous report demonstrated that P2Y12 inhibition in vitro attenuates coated-platele...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2008-12, Vol.52 (6), p.536-539
Hauptverfasser:	Norgard, Nicholas B, Saya, S, Hann, C L, Hennebry, T A, Schechter, E, Dale, G L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Aged Aged, 80 and over Blood Platelets - drug effects Blood Platelets - metabolism Cardiac Catheterization Coronary Angiography Crotalid Venoms Female Fibrinolytic Agents - therapeutic use Humans Lectins, C-Type Male Middle Aged Platelet Activation - drug effects Platelet Aggregation Inhibitors - therapeutic use Platelet Function Tests Purinergic P2 Receptor Antagonists Receptors, Purinergic P2 - blood Receptors, Purinergic P2Y12 Thrombin Ticlopidine - analogs & derivatives Ticlopidine - therapeutic use
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