Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?
Abstract Background Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. Methods To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383...
Gespeichert in:
| Veröffentlicht in: | The American journal of surgery 2008-12, Vol.196 (6), p.948-960 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 960 |
|---|---|
| container_issue | 6 |
| container_start_page | 948 |
| container_title | The American journal of surgery |
| container_volume | 196 |
| creator | Moore, Frederick A., M.D Nelson, Teresa, M.S McKinley, Bruce A., Ph.D Moore, Ernest E., M.D Nathens, Avery B., M.D., Ph.D., M.P.H Rhee, Peter, M.D., M.P.H Puyana, Juan Carlos, M.D Beilman, Gregory J., M.D Cohn, Stephen M., M.D |
| description | Abstract Background Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. Methods To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383 civilians. Results Ninety-three (24%) of the traumatic shock civilians received a MT, of which 26 (28%) died early, predominantly from bleeding within 6 hours. Comparatively, this early MT death cohort arrived in more severe shock and were coagulopathic (mean INR 2.4). In the critical period of MT (ie, the first 3 hours), these patients received 20 U of packed red blood cells (PRBCs) but only 4 U of fresh frozen plasma (FFP). They remained severely acidotic and their coagulopathy worsened as they exsanquinated. Conclusion Civilians who arrived in traumatic shock, required a MT, and died early had worsening coagulopathy, which was not treated. DCR with FFP may have a role in civilian trauma. |
| doi_str_mv | 10.1016/j.amjsurg.2008.07.043 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69908194</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002961008006806</els_id><sourcerecordid>3106598611</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-489581da3c28cbc4b0540523a50c698809ac64530202fc6bb1542237050e2d7f3</originalsourceid><addsrcrecordid>eNqFkl2L1TAQhoMo7nH1JygBwbvWSZq0yY3LsvixsOCFeh3SdHo2tW2OSXtg_fWmnAMLeyOBhAnPvJPMO4S8ZVAyYPXHobTTkNa4LzmAKqEpQVTPyI6pRhdMqeo52QEAL3TN4IK8SmnIIWOiekkumAYtGZM7Mt0mutxjRGppDCPSPkRq9_uIKfkj0jUhDT3tc3yf9_AXZ3oYbZos9TOd7Ilaop1TvyYf5o12_uhHb-ftfs3kwS4e5yVdvSYvejsmfHM-L8mvL59_3nwr7r5_vb25viucEPVSCKWlYp2tHFeudaIFKUDyykpwtVYKtHW1kBVw4L2r25ZJwXnVgATkXdNXl-TDSfcQw58V02ImnxyOo50xrMnUWoNiWmTw_RNwCGuc89sME0KwbTWZkifKxZBSxN4cop9sfDAMzOaGGczZDbO5YaAx2Y2c9-6svrYTdo9Z5_Zn4OoEYG7G0WM0yeVOOex8RLeYLvj_lvj0RMGNfvbOjr_xAdPjb0ziBsyPbSS2iQAFUCuoq3-yhrIh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1444141417</pqid></control><display><type>article</type><title>Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Moore, Frederick A., M.D ; Nelson, Teresa, M.S ; McKinley, Bruce A., Ph.D ; Moore, Ernest E., M.D ; Nathens, Avery B., M.D., Ph.D., M.P.H ; Rhee, Peter, M.D., M.P.H ; Puyana, Juan Carlos, M.D ; Beilman, Gregory J., M.D ; Cohn, Stephen M., M.D</creator><creatorcontrib>Moore, Frederick A., M.D ; Nelson, Teresa, M.S ; McKinley, Bruce A., Ph.D ; Moore, Ernest E., M.D ; Nathens, Avery B., M.D., Ph.D., M.P.H ; Rhee, Peter, M.D., M.P.H ; Puyana, Juan Carlos, M.D ; Beilman, Gregory J., M.D ; Cohn, Stephen M., M.D ; StO ; Study Group ; StO2 Study Group</creatorcontrib><description>Abstract Background Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. Methods To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383 civilians. Results Ninety-three (24%) of the traumatic shock civilians received a MT, of which 26 (28%) died early, predominantly from bleeding within 6 hours. Comparatively, this early MT death cohort arrived in more severe shock and were coagulopathic (mean INR 2.4). In the critical period of MT (ie, the first 3 hours), these patients received 20 U of packed red blood cells (PRBCs) but only 4 U of fresh frozen plasma (FFP). They remained severely acidotic and their coagulopathy worsened as they exsanquinated. Conclusion Civilians who arrived in traumatic shock, required a MT, and died early had worsening coagulopathy, which was not treated. DCR with FFP may have a role in civilian trauma.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2008.07.043</identifier><identifier>PMID: 19095115</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Component Transfusion - methods ; Brain damage ; Casualties ; Coagulopathy ; Consent ; Critical Care - methods ; Female ; Follow-Up Studies ; Humans ; Male ; Massive transfusion ; Middle Aged ; Mortality ; Multiple organ failure ; Plasma ; Prospective Studies ; Respiratory distress syndrome ; StO 2 ; Surgery ; Time Factors ; Tissue hemoglobin oxygen saturation ; Trauma Severity Indices ; Traumatic shock ; Treatment Outcome ; Wounds and Injuries - diagnosis ; Wounds and Injuries - therapy ; Young Adult</subject><ispartof>The American journal of surgery, 2008-12, Vol.196 (6), p.948-960</ispartof><rights>2008</rights><rights>Copyright Elsevier Limited Jan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-489581da3c28cbc4b0540523a50c698809ac64530202fc6bb1542237050e2d7f3</citedby><cites>FETCH-LOGICAL-c446t-489581da3c28cbc4b0540523a50c698809ac64530202fc6bb1542237050e2d7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961008006806$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19095115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Frederick A., M.D</creatorcontrib><creatorcontrib>Nelson, Teresa, M.S</creatorcontrib><creatorcontrib>McKinley, Bruce A., Ph.D</creatorcontrib><creatorcontrib>Moore, Ernest E., M.D</creatorcontrib><creatorcontrib>Nathens, Avery B., M.D., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Rhee, Peter, M.D., M.P.H</creatorcontrib><creatorcontrib>Puyana, Juan Carlos, M.D</creatorcontrib><creatorcontrib>Beilman, Gregory J., M.D</creatorcontrib><creatorcontrib>Cohn, Stephen M., M.D</creatorcontrib><creatorcontrib>StO</creatorcontrib><creatorcontrib>Study Group</creatorcontrib><creatorcontrib>StO2 Study Group</creatorcontrib><title>Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. Methods To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383 civilians. Results Ninety-three (24%) of the traumatic shock civilians received a MT, of which 26 (28%) died early, predominantly from bleeding within 6 hours. Comparatively, this early MT death cohort arrived in more severe shock and were coagulopathic (mean INR 2.4). In the critical period of MT (ie, the first 3 hours), these patients received 20 U of packed red blood cells (PRBCs) but only 4 U of fresh frozen plasma (FFP). They remained severely acidotic and their coagulopathy worsened as they exsanquinated. Conclusion Civilians who arrived in traumatic shock, required a MT, and died early had worsening coagulopathy, which was not treated. DCR with FFP may have a role in civilian trauma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Component Transfusion - methods</subject><subject>Brain damage</subject><subject>Casualties</subject><subject>Coagulopathy</subject><subject>Consent</subject><subject>Critical Care - methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Massive transfusion</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multiple organ failure</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Respiratory distress syndrome</subject><subject>StO 2</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Tissue hemoglobin oxygen saturation</subject><subject>Trauma Severity Indices</subject><subject>Traumatic shock</subject><subject>Treatment Outcome</subject><subject>Wounds and Injuries - diagnosis</subject><subject>Wounds and Injuries - therapy</subject><subject>Young Adult</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1JygBwbvWSZq0yY3LsvixsOCFeh3SdHo2tW2OSXtg_fWmnAMLeyOBhAnPvJPMO4S8ZVAyYPXHobTTkNa4LzmAKqEpQVTPyI6pRhdMqeo52QEAL3TN4IK8SmnIIWOiekkumAYtGZM7Mt0mutxjRGppDCPSPkRq9_uIKfkj0jUhDT3tc3yf9_AXZ3oYbZos9TOd7Ilaop1TvyYf5o12_uhHb-ftfs3kwS4e5yVdvSYvejsmfHM-L8mvL59_3nwr7r5_vb25viucEPVSCKWlYp2tHFeudaIFKUDyykpwtVYKtHW1kBVw4L2r25ZJwXnVgATkXdNXl-TDSfcQw58V02ImnxyOo50xrMnUWoNiWmTw_RNwCGuc89sME0KwbTWZkifKxZBSxN4cop9sfDAMzOaGGczZDbO5YaAx2Y2c9-6svrYTdo9Z5_Zn4OoEYG7G0WM0yeVOOex8RLeYLvj_lvj0RMGNfvbOjr_xAdPjb0ziBsyPbSS2iQAFUCuoq3-yhrIh</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Moore, Frederick A., M.D</creator><creator>Nelson, Teresa, M.S</creator><creator>McKinley, Bruce A., Ph.D</creator><creator>Moore, Ernest E., M.D</creator><creator>Nathens, Avery B., M.D., Ph.D., M.P.H</creator><creator>Rhee, Peter, M.D., M.P.H</creator><creator>Puyana, Juan Carlos, M.D</creator><creator>Beilman, Gregory J., M.D</creator><creator>Cohn, Stephen M., M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?</title><author>Moore, Frederick A., M.D ; Nelson, Teresa, M.S ; McKinley, Bruce A., Ph.D ; Moore, Ernest E., M.D ; Nathens, Avery B., M.D., Ph.D., M.P.H ; Rhee, Peter, M.D., M.P.H ; Puyana, Juan Carlos, M.D ; Beilman, Gregory J., M.D ; Cohn, Stephen M., M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-489581da3c28cbc4b0540523a50c698809ac64530202fc6bb1542237050e2d7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Component Transfusion - methods</topic><topic>Brain damage</topic><topic>Casualties</topic><topic>Coagulopathy</topic><topic>Consent</topic><topic>Critical Care - methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Massive transfusion</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multiple organ failure</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Respiratory distress syndrome</topic><topic>StO 2</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Tissue hemoglobin oxygen saturation</topic><topic>Trauma Severity Indices</topic><topic>Traumatic shock</topic><topic>Treatment Outcome</topic><topic>Wounds and Injuries - diagnosis</topic><topic>Wounds and Injuries - therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Frederick A., M.D</creatorcontrib><creatorcontrib>Nelson, Teresa, M.S</creatorcontrib><creatorcontrib>McKinley, Bruce A., Ph.D</creatorcontrib><creatorcontrib>Moore, Ernest E., M.D</creatorcontrib><creatorcontrib>Nathens, Avery B., M.D., Ph.D., M.P.H</creatorcontrib><creatorcontrib>Rhee, Peter, M.D., M.P.H</creatorcontrib><creatorcontrib>Puyana, Juan Carlos, M.D</creatorcontrib><creatorcontrib>Beilman, Gregory J., M.D</creatorcontrib><creatorcontrib>Cohn, Stephen M., M.D</creatorcontrib><creatorcontrib>StO</creatorcontrib><creatorcontrib>Study Group</creatorcontrib><creatorcontrib>StO2 Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Frederick A., M.D</au><au>Nelson, Teresa, M.S</au><au>McKinley, Bruce A., Ph.D</au><au>Moore, Ernest E., M.D</au><au>Nathens, Avery B., M.D., Ph.D., M.P.H</au><au>Rhee, Peter, M.D., M.P.H</au><au>Puyana, Juan Carlos, M.D</au><au>Beilman, Gregory J., M.D</au><au>Cohn, Stephen M., M.D</au><aucorp>StO</aucorp><aucorp>Study Group</aucorp><aucorp>StO2 Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>196</volume><issue>6</issue><spage>948</spage><epage>960</epage><pages>948-960</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background Damage control resuscitation (DCR) with early plasma in combat casualties requiring massive transfusion (MT) decreases early deaths from bleeding. Methods To ascertain the potential role of early plasma DCR in civilian MT, we queried a prospective traumatic shock database of 383 civilians. Results Ninety-three (24%) of the traumatic shock civilians received a MT, of which 26 (28%) died early, predominantly from bleeding within 6 hours. Comparatively, this early MT death cohort arrived in more severe shock and were coagulopathic (mean INR 2.4). In the critical period of MT (ie, the first 3 hours), these patients received 20 U of packed red blood cells (PRBCs) but only 4 U of fresh frozen plasma (FFP). They remained severely acidotic and their coagulopathy worsened as they exsanquinated. Conclusion Civilians who arrived in traumatic shock, required a MT, and died early had worsening coagulopathy, which was not treated. DCR with FFP may have a role in civilian trauma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19095115</pmid><doi>10.1016/j.amjsurg.2008.07.043</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9610 |
| ispartof | The American journal of surgery, 2008-12, Vol.196 (6), p.948-960 |
| issn | 0002-9610 1879-1883 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69908194 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Blood Component Transfusion - methods Brain damage Casualties Coagulopathy Consent Critical Care - methods Female Follow-Up Studies Humans Male Massive transfusion Middle Aged Mortality Multiple organ failure Plasma Prospective Studies Respiratory distress syndrome StO 2 Surgery Time Factors Tissue hemoglobin oxygen saturation Trauma Severity Indices Traumatic shock Treatment Outcome Wounds and Injuries - diagnosis Wounds and Injuries - therapy Young Adult |
| title | Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T12%3A55%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Is%20there%20a%20role%20for%20aggressive%20use%20of%20fresh%20frozen%20plasma%20in%20massive%20transfusion%20of%20civilian%20trauma%20patients?&rft.jtitle=The%20American%20journal%20of%20surgery&rft.au=Moore,%20Frederick%20A.,%20M.D&rft.aucorp=StO&rft.date=2008-12-01&rft.volume=196&rft.issue=6&rft.spage=948&rft.epage=960&rft.pages=948-960&rft.issn=0002-9610&rft.eissn=1879-1883&rft_id=info:doi/10.1016/j.amjsurg.2008.07.043&rft_dat=%3Cproquest_cross%3E3106598611%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1444141417&rft_id=info:pmid/19095115&rft_els_id=S0002961008006806&rfr_iscdi=true |