Metalloproteinase-mediated release of the ectodomain of L1 adhesion molecule

The L1 adhesion molecule is an approx. 200-220 kDa type I membrane glycoprotein belonging to the immunoglobulin (Ig) superfamily. L1 can bind in a homotypic fashion and was shown to support integrin-mediated binding via RGDs in the 6th Ig-like domain. In addition to its cell-surface expression, L1 c...

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Veröffentlicht in:	Journal of cell science 1999-08, Vol.112 ( Pt 16) (16), p.2667-2675
Hauptverfasser:	Beer, S, Oleszewski, M, Gutwein, P, Geiger, C, Altevogt, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Surface - chemistry Antigens, Surface - metabolism Cell Adhesion - drug effects Cell Adhesion - physiology Cell Movement - drug effects Cell Movement - physiology CHO Cells COS Cells Cricetinae Cytoplasm - chemistry Cytoplasm - metabolism Dipeptides - pharmacology Humans Hybridomas Hydroxamic Acids - pharmacology L-Selectin - metabolism Leukocyte L1 Antigen Complex Melanoma Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - metabolism Mice Mice, Inbred DBA Multiple Myeloma Neural Cell Adhesion Molecules - chemistry Neural Cell Adhesion Molecules - metabolism Neuroblastoma Protease Inhibitors - pharmacology Protein Structure, Tertiary Spleen - cytology Tumor Cells, Cultured - chemistry Tumor Cells, Cultured - cytology Tumor Cells, Cultured - metabolism
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