Neurobrucellosis with thalamic infarction: a case report

Brucellosis is prevalent in North and East Africa, the Middle East, South and Central Asia, South and Central America and the Mediterranean countries of Europe. In 5% of cases it may lead to central nervous system manifestation presenting most often as a meningitis or meningoencephalitis. Here we re...

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Veröffentlicht in:	Neurological sciences 2008-12, Vol.29 (6), p.481-483
Hauptverfasser:	Jochum, Thomas, Kliesch, Uta, Both, Reinhard, Leonhardi, Jochen, Bär, Karl-Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abducens Nerve Diseases - microbiology Abducens Nerve Diseases - pathology Abducens Nerve Diseases - physiopathology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - therapeutic use Brain Infarction - microbiology Brain Infarction - pathology Brain Infarction - physiopathology Brucella Brucella - immunology Brucellosis - complications Case Report Cranial Nerve Diseases - microbiology Cranial Nerve Diseases - physiopathology Doxycycline - therapeutic use Headache - microbiology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Meningitis, Bacterial - microbiology Meningitis, Bacterial - physiopathology Methylprednisolone - therapeutic use Middle Aged Neurology Neuroradiology Neurosciences Neurosurgery Psychiatry Rifampin - therapeutic use Thalamic Diseases - microbiology Thalamic Diseases - pathology Thalamic Diseases - physiopathology Treatment Outcome
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container_title	Neurological sciences
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creator	Jochum, Thomas Kliesch, Uta Both, Reinhard Leonhardi, Jochen Bär, Karl-Jürgen
description	Brucellosis is prevalent in North and East Africa, the Middle East, South and Central Asia, South and Central America and the Mediterranean countries of Europe. In 5% of cases it may lead to central nervous system manifestation presenting most often as a meningitis or meningoencephalitis. Here we report and discuss a case of neurobrucellosis with meningitis with cranial nerves neuritis. A 56-year-old German male was admitted with bilateral abducens nerve palsy, amblyacousia and intractable headaches. An enzyme-linked immunosorbent assay (ELISA) revealed antibodies against Brucella in serum and cerebrospinal fluid (CSF). Additionally, our patient suffered from an infarction of the left thalamus. In conclusion, in cases of unresponsive meningitis or meningoencephalitis and history of travel in endemic regions, neurobrucellosis should be considered. If initial microbiological tests fail, complementary investigations such as ELISA are indicated to detect Brucella species in serum and/or CSF.
doi_str_mv	10.1007/s10072-008-1017-z
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If initial microbiological tests fail, complementary investigations such as ELISA are indicated to detect Brucella species in serum and/or CSF.</description><subject>Abducens Nerve Diseases - microbiology</subject><subject>Abducens Nerve Diseases - pathology</subject><subject>Abducens Nerve Diseases - physiopathology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Brain Infarction - microbiology</subject><subject>Brain Infarction - pathology</subject><subject>Brain Infarction - physiopathology</subject><subject>Brucella</subject><subject>Brucella - immunology</subject><subject>Brucellosis - complications</subject><subject>Case Report</subject><subject>Cranial Nerve Diseases - microbiology</subject><subject>Cranial Nerve Diseases - physiopathology</subject><subject>Doxycycline - therapeutic use</subject><subject>Headache - microbiology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meningitis, Bacterial - 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Academic</collection><jtitle>Neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jochum, Thomas</au><au>Kliesch, Uta</au><au>Both, Reinhard</au><au>Leonhardi, Jochen</au><au>Bär, Karl-Jürgen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurobrucellosis with thalamic infarction: a case report</atitle><jtitle>Neurological sciences</jtitle><stitle>Neurol Sci</stitle><addtitle>Neurol Sci</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>29</volume><issue>6</issue><spage>481</spage><epage>483</epage><pages>481-483</pages><issn>1590-1874</issn><eissn>1590-3478</eissn><abstract>Brucellosis is prevalent in North and East Africa, the Middle East, South and Central Asia, South and Central America and the Mediterranean countries of Europe. In 5% of cases it may lead to central nervous system manifestation presenting most often as a meningitis or meningoencephalitis. Here we report and discuss a case of neurobrucellosis with meningitis with cranial nerves neuritis. A 56-year-old German male was admitted with bilateral abducens nerve palsy, amblyacousia and intractable headaches. An enzyme-linked immunosorbent assay (ELISA) revealed antibodies against Brucella in serum and cerebrospinal fluid (CSF). Additionally, our patient suffered from an infarction of the left thalamus. In conclusion, in cases of unresponsive meningitis or meningoencephalitis and history of travel in endemic regions, neurobrucellosis should be considered. If initial microbiological tests fail, complementary investigations such as ELISA are indicated to detect Brucella species in serum and/or CSF.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>18854918</pmid><doi>10.1007/s10072-008-1017-z</doi><tpages>3</tpages></addata></record>
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subjects	Abducens Nerve Diseases - microbiology Abducens Nerve Diseases - pathology Abducens Nerve Diseases - physiopathology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - therapeutic use Brain Infarction - microbiology Brain Infarction - pathology Brain Infarction - physiopathology Brucella Brucella - immunology Brucellosis - complications Case Report Cranial Nerve Diseases - microbiology Cranial Nerve Diseases - physiopathology Doxycycline - therapeutic use Headache - microbiology Humans Magnetic Resonance Imaging Male Medicine Medicine & Public Health Meningitis, Bacterial - microbiology Meningitis, Bacterial - physiopathology Methylprednisolone - therapeutic use Middle Aged Neurology Neuroradiology Neurosciences Neurosurgery Psychiatry Rifampin - therapeutic use Thalamic Diseases - microbiology Thalamic Diseases - pathology Thalamic Diseases - physiopathology Treatment Outcome
title	Neurobrucellosis with thalamic infarction: a case report
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