Antiparasitic, nematicidal and antifouling constituents from Juniperus berries
A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium f...
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| Veröffentlicht in: | Phytotherapy research 2008-12, Vol.22 (12), p.1570-1576 |
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| creator | Samoylenko, Volodymyr Dunbar, D. Chuck Gafur, Md. Abdul Khan, Shabana I Ross, Samir A Mossa, Jaber S El-Feraly, Farouk S Tekwani, Babu L Bosselaers, Jan Muhammad, Ilias |
| description | A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC₅₀ = 1.9 and 2.0 μg/mL, respectively), while totarol (6), ferruginol (7) and 7β-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC₅₀ values of 3.5-4.6 μg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 μg/mL and 1 μg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2460 |
| format | Article |
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Chuck ; Gafur, Md. Abdul ; Khan, Shabana I ; Ross, Samir A ; Mossa, Jaber S ; El-Feraly, Farouk S ; Tekwani, Babu L ; Bosselaers, Jan ; Muhammad, Ilias</creator><creatorcontrib>Samoylenko, Volodymyr ; Dunbar, D. Chuck ; Gafur, Md. Abdul ; Khan, Shabana I ; Ross, Samir A ; Mossa, Jaber S ; El-Feraly, Farouk S ; Tekwani, Babu L ; Bosselaers, Jan ; Muhammad, Ilias</creatorcontrib><description>A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC₅₀ = 1.9 and 2.0 μg/mL, respectively), while totarol (6), ferruginol (7) and 7β-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC₅₀ values of 3.5-4.6 μg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 μg/mL and 1 μg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2460</identifier><identifier>PMID: 19067375</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; antifouling ; Antinematodal Agents - pharmacology ; antiparasitic ; Antiprotozoal Agents - pharmacology ; Artemia - drug effects ; Biological and medical sciences ; Caenorhabditis elegans - drug effects ; diterpenes ; Diterpenes - pharmacology ; Diterpenes, Abietane - pharmacology ; Fruit - chemistry ; Gas Chromatography-Mass Spectrometry ; General pharmacology ; J. excelsa ; J. phoenicea ; J. virginiana ; Juniperus - chemistry ; Juniperus procera ; Leishmania donovani - drug effects ; Medical sciences ; Microbial Sensitivity Tests ; nematicidal ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plasmodium falciparum - drug effects ; Resins, Plant - chemistry</subject><ispartof>Phytotherapy research, 2008-12, Vol.22 (12), p.1570-1576</ispartof><rights>Copyright © 2008 John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><rights>(c) 2008 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4110-517617b9dba94bb2deb39579f5f6b6faf4af865654ff06ad94d19f47ce87b79e3</citedby><cites>FETCH-LOGICAL-c4110-517617b9dba94bb2deb39579f5f6b6faf4af865654ff06ad94d19f47ce87b79e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2460$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2460$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20953168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19067375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samoylenko, Volodymyr</creatorcontrib><creatorcontrib>Dunbar, D. Chuck</creatorcontrib><creatorcontrib>Gafur, Md. Abdul</creatorcontrib><creatorcontrib>Khan, Shabana I</creatorcontrib><creatorcontrib>Ross, Samir A</creatorcontrib><creatorcontrib>Mossa, Jaber S</creatorcontrib><creatorcontrib>El-Feraly, Farouk S</creatorcontrib><creatorcontrib>Tekwani, Babu L</creatorcontrib><creatorcontrib>Bosselaers, Jan</creatorcontrib><creatorcontrib>Muhammad, Ilias</creatorcontrib><title>Antiparasitic, nematicidal and antifouling constituents from Juniperus berries</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC₅₀ = 1.9 and 2.0 μg/mL, respectively), while totarol (6), ferruginol (7) and 7β-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC₅₀ values of 3.5-4.6 μg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 μg/mL and 1 μg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antifouling</subject><subject>Antinematodal Agents - pharmacology</subject><subject>antiparasitic</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Artemia - drug effects</subject><subject>Biological and medical sciences</subject><subject>Caenorhabditis elegans - drug effects</subject><subject>diterpenes</subject><subject>Diterpenes - pharmacology</subject><subject>Diterpenes, Abietane - pharmacology</subject><subject>Fruit - chemistry</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>General pharmacology</subject><subject>J. excelsa</subject><subject>J. phoenicea</subject><subject>J. virginiana</subject><subject>Juniperus - chemistry</subject><subject>Juniperus procera</subject><subject>Leishmania donovani - drug effects</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>nematicidal</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Abdul</creator><creator>Khan, Shabana I</creator><creator>Ross, Samir A</creator><creator>Mossa, Jaber S</creator><creator>El-Feraly, Farouk S</creator><creator>Tekwani, Babu L</creator><creator>Bosselaers, Jan</creator><creator>Muhammad, Ilias</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Antiparasitic, nematicidal and antifouling constituents from Juniperus berries</title><author>Samoylenko, Volodymyr ; Dunbar, D. Chuck ; Gafur, Md. Abdul ; Khan, Shabana I ; Ross, Samir A ; Mossa, Jaber S ; El-Feraly, Farouk S ; Tekwani, Babu L ; Bosselaers, Jan ; Muhammad, Ilias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4110-517617b9dba94bb2deb39579f5f6b6faf4af865654ff06ad94d19f47ce87b79e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antifouling</topic><topic>Antinematodal Agents - pharmacology</topic><topic>antiparasitic</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Artemia - drug effects</topic><topic>Biological and medical sciences</topic><topic>Caenorhabditis elegans - drug effects</topic><topic>diterpenes</topic><topic>Diterpenes - pharmacology</topic><topic>Diterpenes, Abietane - pharmacology</topic><topic>Fruit - chemistry</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>General pharmacology</topic><topic>J. excelsa</topic><topic>J. phoenicea</topic><topic>J. virginiana</topic><topic>Juniperus - chemistry</topic><topic>Juniperus procera</topic><topic>Leishmania donovani - drug effects</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>nematicidal</topic><topic>Pharmacognosy. 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Abdul</au><au>Khan, Shabana I</au><au>Ross, Samir A</au><au>Mossa, Jaber S</au><au>El-Feraly, Farouk S</au><au>Tekwani, Babu L</au><au>Bosselaers, Jan</au><au>Muhammad, Ilias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiparasitic, nematicidal and antifouling constituents from Juniperus berries</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2008-12</date><risdate>2008</risdate><volume>22</volume><issue>12</issue><spage>1570</spage><epage>1576</epage><pages>1570-1576</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC₅₀ = 1.9 and 2.0 μg/mL, respectively), while totarol (6), ferruginol (7) and 7β-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC₅₀ values of 3.5-4.6 μg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 μg/mL and 1 μg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19067375</pmid><doi>10.1002/ptr.2460</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - pharmacology antifouling Antinematodal Agents - pharmacology antiparasitic Antiprotozoal Agents - pharmacology Artemia - drug effects Biological and medical sciences Caenorhabditis elegans - drug effects diterpenes Diterpenes - pharmacology Diterpenes, Abietane - pharmacology Fruit - chemistry Gas Chromatography-Mass Spectrometry General pharmacology J. excelsa J. phoenicea J. virginiana Juniperus - chemistry Juniperus procera Leishmania donovani - drug effects Medical sciences Microbial Sensitivity Tests nematicidal Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plasmodium falciparum - drug effects Resins, Plant - chemistry |
| title | Antiparasitic, nematicidal and antifouling constituents from Juniperus berries |
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