p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer
In this study, we evaluated the prognostic significance of both p53 overexpression and proliferating activity in 133 primary ductal pancreatic carcinomas and in their regional synchronous lymph node metastases by immunohistochemistry, by using DO7 and MIB1 monoclonal antibodies, respectively. Tumor...
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| Veröffentlicht in: | Pancreas 1999-07, Vol.19 (1), p.26-32 |
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| creator | CAMPANI, D BOGGI, U CECCHETTI, D ESPOSITO, I CECCARELLI, F D'ANTONIO, L DE NEGRI, F MOSCA, F BEVILACQUA, G FORNACIARI, G |
| description | In this study, we evaluated the prognostic significance of both p53 overexpression and proliferating activity in 133 primary ductal pancreatic carcinomas and in their regional synchronous lymph node metastases by immunohistochemistry, by using DO7 and MIB1 monoclonal antibodies, respectively. Tumor samples and lymph nodes were obtained from formalin-fixed, paraffin-embedded archival material of patients operated on between 1976 and 1996. Patients had a well-documented clinical history and were given accurate follow-up. p53 accumulation was observed in 77 (54%) of 133 primary tumors and in 22 (44%) of 50 patients with nodal metastases. The p53 overexpression was directly related to proliferating activity (p = 0.01) in the primary tumors. A significant direct correlation was present between the p53 expression in the primary tumor and in nodal metastases (p = 0.01); the same occurred for proliferating activity by MIB1 (p = 0.002). The patients' overall survival was affected by the presence of nodal (p = 0.02) and distant (p = 0.0001) metastases. The p53 immunoreactivity in nodal metastases was associated with a statistically significant decrease in the postoperative survival period (p = 0.005). Multivariate analysis confirmed these results, and the only two parameters that maintained statistical significance were M1 status (p = 0.0006) and p53 overexpression in nodal metastases (p = 0.01). |
| doi_str_mv | 10.1097/00006676-199907000-00004 |
| format | Article |
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Tumor samples and lymph nodes were obtained from formalin-fixed, paraffin-embedded archival material of patients operated on between 1976 and 1996. Patients had a well-documented clinical history and were given accurate follow-up. p53 accumulation was observed in 77 (54%) of 133 primary tumors and in 22 (44%) of 50 patients with nodal metastases. The p53 overexpression was directly related to proliferating activity (p = 0.01) in the primary tumors. A significant direct correlation was present between the p53 expression in the primary tumor and in nodal metastases (p = 0.01); the same occurred for proliferating activity by MIB1 (p = 0.002). The patients' overall survival was affected by the presence of nodal (p = 0.02) and distant (p = 0.0001) metastases. The p53 immunoreactivity in nodal metastases was associated with a statistically significant decrease in the postoperative survival period (p = 0.005). Multivariate analysis confirmed these results, and the only two parameters that maintained statistical significance were M1 status (p = 0.0006) and p53 overexpression in nodal metastases (p = 0.01).</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-199907000-00004</identifier><identifier>PMID: 10416688</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - secondary ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal - metabolism ; Antigens, Nuclear ; Biological and medical sciences ; Cell Division ; Digestive system ; Female ; Humans ; Immunoenzyme Techniques ; Investigative techniques, diagnostic techniques (general aspects) ; Ki-67 Antigen - metabolism ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Nuclear Proteins - metabolism ; Pancreatic Neoplasms - metabolism ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Survival Rate ; Treatment Outcome ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Pancreas, 1999-07, Vol.19 (1), p.26-32</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-129a81e37fab6fe2fa08bdfcecaad9ba40cde38aeb073ef848606d58095d87a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1907906$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10416688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAMPANI, D</creatorcontrib><creatorcontrib>BOGGI, U</creatorcontrib><creatorcontrib>CECCHETTI, D</creatorcontrib><creatorcontrib>ESPOSITO, I</creatorcontrib><creatorcontrib>CECCARELLI, F</creatorcontrib><creatorcontrib>D'ANTONIO, L</creatorcontrib><creatorcontrib>DE NEGRI, F</creatorcontrib><creatorcontrib>MOSCA, F</creatorcontrib><creatorcontrib>BEVILACQUA, G</creatorcontrib><creatorcontrib>FORNACIARI, G</creatorcontrib><title>p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>In this study, we evaluated the prognostic significance of both p53 overexpression and proliferating activity in 133 primary ductal pancreatic carcinomas and in their regional synchronous lymph node metastases by immunohistochemistry, by using DO7 and MIB1 monoclonal antibodies, respectively. Tumor samples and lymph nodes were obtained from formalin-fixed, paraffin-embedded archival material of patients operated on between 1976 and 1996. Patients had a well-documented clinical history and were given accurate follow-up. p53 accumulation was observed in 77 (54%) of 133 primary tumors and in 22 (44%) of 50 patients with nodal metastases. The p53 overexpression was directly related to proliferating activity (p = 0.01) in the primary tumors. A significant direct correlation was present between the p53 expression in the primary tumor and in nodal metastases (p = 0.01); the same occurred for proliferating activity by MIB1 (p = 0.002). The patients' overall survival was affected by the presence of nodal (p = 0.02) and distant (p = 0.0001) metastases. The p53 immunoreactivity in nodal metastases was associated with a statistically significant decrease in the postoperative survival period (p = 0.005). Multivariate analysis confirmed these results, and the only two parameters that maintained statistical significance were M1 status (p = 0.0006) and p53 overexpression in nodal metastases (p = 0.01).</description><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antigens, Nuclear</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Digestive system</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nuclear Proteins - metabolism</subject><subject>Pancreatic Neoplasms - metabolism</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKAzEUhoMotlZfQbIQd6NJM5PLUoo3KLjR9XAmOYORuZnMiH17U1svIZDk5_tP4COEcnbFmVHXLC0plcy4MYap9Mq2UX5A5rwQMsv1Uh-SOdO6yARXakZOYnxjjCtRmGMy4yznUmo9JzAUgvYfGPBzCBij7zvqO9ps2uGVdr1D2uIIMW2MNBHO2zFS2_jOW2hoP422b3FbcZMdUzJAZwPC6C216YrhlBzV0EQ8258L8nJ3-7x6yNZP94-rm3VmhTRjxpcGNEehaqhkjcsamK5cbdECOFNBzqxDoQErpgTWOteSSVdoZgqnFSzFglzu5g6hf58wjmXro8WmgQ77KZYymeJcyATqHWhDH2PAuhyCbyFsSs7Krd7yR2_5q_c7ylP1fP_HVLXo_hV3PhNwsQcgJj91SAp8_OPSNMOk-AIOSoS9</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>CAMPANI, D</creator><creator>BOGGI, U</creator><creator>CECCHETTI, D</creator><creator>ESPOSITO, I</creator><creator>CECCARELLI, F</creator><creator>D'ANTONIO, L</creator><creator>DE NEGRI, F</creator><creator>MOSCA, F</creator><creator>BEVILACQUA, G</creator><creator>FORNACIARI, G</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer</title><author>CAMPANI, D ; BOGGI, U ; CECCHETTI, D ; ESPOSITO, I ; CECCARELLI, F ; D'ANTONIO, L ; DE NEGRI, F ; MOSCA, F ; BEVILACQUA, G ; FORNACIARI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-129a81e37fab6fe2fa08bdfcecaad9ba40cde38aeb073ef848606d58095d87a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - secondary</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Antigens, Nuclear</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Digestive system</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nuclear Proteins - metabolism</topic><topic>Pancreatic Neoplasms - metabolism</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAMPANI, D</creatorcontrib><creatorcontrib>BOGGI, U</creatorcontrib><creatorcontrib>CECCHETTI, D</creatorcontrib><creatorcontrib>ESPOSITO, I</creatorcontrib><creatorcontrib>CECCARELLI, F</creatorcontrib><creatorcontrib>D'ANTONIO, L</creatorcontrib><creatorcontrib>DE NEGRI, F</creatorcontrib><creatorcontrib>MOSCA, F</creatorcontrib><creatorcontrib>BEVILACQUA, G</creatorcontrib><creatorcontrib>FORNACIARI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAMPANI, D</au><au>BOGGI, U</au><au>CECCHETTI, D</au><au>ESPOSITO, I</au><au>CECCARELLI, F</au><au>D'ANTONIO, L</au><au>DE NEGRI, F</au><au>MOSCA, F</au><au>BEVILACQUA, G</au><au>FORNACIARI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>19</volume><issue>1</issue><spage>26</spage><epage>32</epage><pages>26-32</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>In this study, we evaluated the prognostic significance of both p53 overexpression and proliferating activity in 133 primary ductal pancreatic carcinomas and in their regional synchronous lymph node metastases by immunohistochemistry, by using DO7 and MIB1 monoclonal antibodies, respectively. Tumor samples and lymph nodes were obtained from formalin-fixed, paraffin-embedded archival material of patients operated on between 1976 and 1996. Patients had a well-documented clinical history and were given accurate follow-up. p53 accumulation was observed in 77 (54%) of 133 primary tumors and in 22 (44%) of 50 patients with nodal metastases. The p53 overexpression was directly related to proliferating activity (p = 0.01) in the primary tumors. A significant direct correlation was present between the p53 expression in the primary tumor and in nodal metastases (p = 0.01); the same occurred for proliferating activity by MIB1 (p = 0.002). The patients' overall survival was affected by the presence of nodal (p = 0.02) and distant (p = 0.0001) metastases. The p53 immunoreactivity in nodal metastases was associated with a statistically significant decrease in the postoperative survival period (p = 0.005). Multivariate analysis confirmed these results, and the only two parameters that maintained statistical significance were M1 status (p = 0.0006) and p53 overexpression in nodal metastases (p = 0.01).</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10416688</pmid><doi>10.1097/00006676-199907000-00004</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - secondary Adult Aged Aged, 80 and over Antibodies, Monoclonal - metabolism Antigens, Nuclear Biological and medical sciences Cell Division Digestive system Female Humans Immunoenzyme Techniques Investigative techniques, diagnostic techniques (general aspects) Ki-67 Antigen - metabolism Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis Male Medical sciences Middle Aged Neoplasm Staging Nuclear Proteins - metabolism Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Survival Rate Treatment Outcome Tumor Suppressor Protein p53 - metabolism |
| title | p53 overexpression in lymph node metastases predicts clinical outcome in ductal pancreatic cancer |
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