Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas

An E1B 55-kDa gene-defective adenovirus (Adv), ONYX-015, has been reported to be a highly useful replication-competent Adv that shows cytopathic effect for cancers with an abnormal p53 gene, without damaging normal tissues. In this study, we combined this Adv (Adv-E1AdB) with a fiber mutation, F/K20...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-07, Vol.59 (14), p.3411-3416
Hauptverfasser:	SHINOURA, N, YOSHIDA, Y, TSUNODA, R, OHASHI, M, WEIPING ZHANG, ASAI, A, KIRINO, T, HAMADA, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1B Proteins - deficiency Adenovirus E1B Proteins - genetics Adenoviruses, Human - genetics Adenoviruses, Human - physiology Animals Antineoplastic agents Biological and medical sciences Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - therapy Capsid - deficiency Capsid - genetics Capsid Proteins Chemotherapy Cytopathogenic Effect, Viral Defective Viruses - genetics Defective Viruses - physiology E1B gene Female Genes, p53 Genetic Therapy Genetic Vectors - genetics Genetic Vectors - physiology Glioblastoma - genetics Glioblastoma - pathology Glioblastoma - therapy Glioma - genetics Glioma - pathology Glioma - therapy Humans Lac Operon Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation p53 gene Pharmacology. Drug treatments Tumor Cells, Cultured Virus Replication
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