Optimum biased-coin designs for sequential treatment allocation with covariate information

Randomized optimum designs of biased‐coin type are compared with other strategies for the sequential allocation of two or more treatments in a clinical trial. The emphasis is on the variance of estimated treatment contrasts. This variance, which depends on the design strategy employed, may be interp...

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Veröffentlicht in:	Statistics in medicine 1999-07, Vol.18 (14), p.1741-1752
1. Verfasser:	Atkinson, Anthony C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bias Biological and medical sciences Computer Simulation Computerized, statistical medical data processing and models in biomedicine Humans Linear Models Medical sciences Medical statistics Models, Biological Randomized Controlled Trials as Topic - standards Randomized Controlled Trials as Topic - statistics & numerical data Regression Analysis
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