New inhibitors of Helicobacter pylori urease holoenzyme selected from phage‐displayed peptide libraries

Urease is an important virulence factor for Helicobacter pylori and is critical for bacterial colonization of the human gastric mucosa. Specific inhibition of urease activity has been proposed as a possible strategy to fight this bacteria which infects billions of individual throughout the world and...

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Veröffentlicht in:	European journal of biochemistry 1999-06, Vol.262 (3), p.774-780
Hauptverfasser:	Houimel, Mehdi, Mach, Jean‐Pierre, Corthésy‐Theulaz, Irène, Corthésy, Blaise, Fisch, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - isolation & purification Bacteriophage M13 - genetics Base Sequence Enzyme Inhibitors - pharmacology Helicobacter pylori Helicobacter pylori - chemistry Helicobacter pylori - enzymology Holoenzymes - metabolism Kinetics Molecular Sequence Data peptide Peptide Library Peptides - genetics Peptides - pharmacology phage display library Protein Binding Substrate Specificity urease Urease - antagonists & inhibitors Urease - isolation & purification
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