Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c

Caspases are cysteine proteases that mediate apoptosis by proteolysis of specific substrates. Although many caspase substrates have been identified, for most substrates the physiologic caspase(s) required for cleavage is unknown. The Bcl-2 protein, which inhibits apoptosis, is cleaved at Asp-34 by c...

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Veröffentlicht in:The Journal of biological chemistry 1999-07, Vol.274 (30), p.21155-21161
Hauptverfasser: Kirsch, David G., Doseff, Andrea, Chau, B. Nelson, Lim, Dae-Sik, de Souza-Pinto, Nadja C., Hansford, Richard, Kastan, Michael B., Lazebnik, Yuri A., Hardwick, J. Marie
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Sprache:eng
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