Reappraisal of peripheral NK cells in women with recurrent miscarriage
Abstract The aim of this study was to examine the relationship between peripheral natural killer (NK) cells and recurrent miscarriage by improved methods. Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed wit...
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| Veröffentlicht in: | Reproductive biomedicine online 2008, Vol.17 (6), p.814-819 |
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| creator | Wang, Qiong Li, Tin-Chu Wu, Yue-Peng Cocksedge, Karen A Fu, Yong-Shui Kong, Qing-Yu Yao, Shu-Zhong |
| description | Abstract The aim of this study was to examine the relationship between peripheral natural killer (NK) cells and recurrent miscarriage by improved methods. Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed within 8 h of collection. Eighty-five Chinese women with recurrent miscarriage who previously tested negative for autoantibodies, and 27 control subjects who were not using any hormonal methods for contraception, were recruited. No significant difference was found in the number of peripheral NK cells and their subsets between women with recurrent miscarriages and control subjects. Only 5% of women with recurrent miscarriage had high peripheral NK cells. The number of previous miscarriages did not appear to have an impact on the number of NK cells. In conclusion, there appears to be limited value in the routine measurement of peripheral NK cells in women with recurrent miscarriage. |
| doi_str_mv | 10.1016/S1472-6483(10)60410-5 |
| format | Article |
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Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed within 8 h of collection. Eighty-five Chinese women with recurrent miscarriage who previously tested negative for autoantibodies, and 27 control subjects who were not using any hormonal methods for contraception, were recruited. No significant difference was found in the number of peripheral NK cells and their subsets between women with recurrent miscarriages and control subjects. Only 5% of women with recurrent miscarriage had high peripheral NK cells. The number of previous miscarriages did not appear to have an impact on the number of NK cells. In conclusion, there appears to be limited value in the routine measurement of peripheral NK cells in women with recurrent miscarriage.</description><identifier>ISSN: 1472-6483</identifier><identifier>EISSN: 1472-6491</identifier><identifier>DOI: 10.1016/S1472-6483(10)60410-5</identifier><identifier>PMID: 19079966</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Abortion, Habitual - blood ; Abortion, Habitual - ethnology ; Adult ; Autoantibodies - metabolism ; Case-Control Studies ; CD56 Antigen - biosynthesis ; Cell Proliferation ; China ; ethnicity ; Female ; Flow Cytometry - methods ; Humans ; Killer Cells, Natural - cytology ; Lewis X Antigen - biosynthesis ; Obstetrics and Gynecology ; peripheral NK cells ; Pregnancy ; recurrent miscarriage ; Reproducibility of Results ; Uterus - metabolism</subject><ispartof>Reproductive biomedicine online, 2008, Vol.17 (6), p.814-819</ispartof><rights>Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK</rights><rights>2008 Reproductive Healthcare Ltd, Duck End Farm, Dry Drayton, Cambridge CB23 8DB, UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-ceda9401e99b55a563282e58161d0a790cc706110cb8a9f08c55fd419cc4e51f3</citedby><cites>FETCH-LOGICAL-c465t-ceda9401e99b55a563282e58161d0a790cc706110cb8a9f08c55fd419cc4e51f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1472-6483(10)60410-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19079966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Li, Tin-Chu</creatorcontrib><creatorcontrib>Wu, Yue-Peng</creatorcontrib><creatorcontrib>Cocksedge, Karen A</creatorcontrib><creatorcontrib>Fu, Yong-Shui</creatorcontrib><creatorcontrib>Kong, Qing-Yu</creatorcontrib><creatorcontrib>Yao, Shu-Zhong</creatorcontrib><title>Reappraisal of peripheral NK cells in women with recurrent miscarriage</title><title>Reproductive biomedicine online</title><addtitle>Reprod Biomed Online</addtitle><description>Abstract The aim of this study was to examine the relationship between peripheral natural killer (NK) cells and recurrent miscarriage by improved methods. Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed within 8 h of collection. Eighty-five Chinese women with recurrent miscarriage who previously tested negative for autoantibodies, and 27 control subjects who were not using any hormonal methods for contraception, were recruited. No significant difference was found in the number of peripheral NK cells and their subsets between women with recurrent miscarriages and control subjects. Only 5% of women with recurrent miscarriage had high peripheral NK cells. The number of previous miscarriages did not appear to have an impact on the number of NK cells. In conclusion, there appears to be limited value in the routine measurement of peripheral NK cells in women with recurrent miscarriage.</description><subject>Abortion, Habitual - blood</subject><subject>Abortion, Habitual - ethnology</subject><subject>Adult</subject><subject>Autoantibodies - metabolism</subject><subject>Case-Control Studies</subject><subject>CD56 Antigen - biosynthesis</subject><subject>Cell Proliferation</subject><subject>China</subject><subject>ethnicity</subject><subject>Female</subject><subject>Flow Cytometry - methods</subject><subject>Humans</subject><subject>Killer Cells, Natural - cytology</subject><subject>Lewis X Antigen - biosynthesis</subject><subject>Obstetrics and Gynecology</subject><subject>peripheral NK cells</subject><subject>Pregnancy</subject><subject>recurrent miscarriage</subject><subject>Reproducibility of Results</subject><subject>Uterus - metabolism</subject><issn>1472-6483</issn><issn>1472-6491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0K1C5tf0JRTqgcAjNJ7NiXoqqiULGiUgtny-tMWG_zhZ2A-u9xdlet1AuX8Xj0zjszD2NnCB8QUHy8x6LMUlHI_BzhvYACIeUHbLEvK3z1lMv8iL0JYQOAEmR-yI5QQamUEAt2fUdmGLxxwTRJXycDeTesycff92-JpaYJieuSv31LMbpxnXiyk_fUjUnrgjXeO_OLTtjr2jSBTvfvMft5_fnH1dd0efvl5upymdpC8DG1VBlVAJJSK84NF3kmM-ISBVZgSgXWliAQwa6kUTVIy3ldFaisLYhjnR-zdzvfwfe_JwqjnpeIW5qO-ilooaQSpcAo5Duh9X0Inmo9eNca_6gR9AxQbwHqmc5c2gLUPPa93Q-YVi1Vz117YlHwaSegeOYfR14H66iLl7lIZtRV7_474uKFg21c56xpHuiRwqaffBcZatQh07AzmT0Qtg48_wfIRpRQ</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Wang, Qiong</creator><creator>Li, Tin-Chu</creator><creator>Wu, Yue-Peng</creator><creator>Cocksedge, Karen A</creator><creator>Fu, Yong-Shui</creator><creator>Kong, Qing-Yu</creator><creator>Yao, Shu-Zhong</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Reappraisal of peripheral NK cells in women with recurrent miscarriage</title><author>Wang, Qiong ; Li, Tin-Chu ; Wu, Yue-Peng ; Cocksedge, Karen A ; Fu, Yong-Shui ; Kong, Qing-Yu ; Yao, Shu-Zhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-ceda9401e99b55a563282e58161d0a790cc706110cb8a9f08c55fd419cc4e51f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abortion, Habitual - blood</topic><topic>Abortion, Habitual - ethnology</topic><topic>Adult</topic><topic>Autoantibodies - metabolism</topic><topic>Case-Control Studies</topic><topic>CD56 Antigen - biosynthesis</topic><topic>Cell Proliferation</topic><topic>China</topic><topic>ethnicity</topic><topic>Female</topic><topic>Flow Cytometry - methods</topic><topic>Humans</topic><topic>Killer Cells, Natural - cytology</topic><topic>Lewis X Antigen - biosynthesis</topic><topic>Obstetrics and Gynecology</topic><topic>peripheral NK cells</topic><topic>Pregnancy</topic><topic>recurrent miscarriage</topic><topic>Reproducibility of Results</topic><topic>Uterus - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Li, Tin-Chu</creatorcontrib><creatorcontrib>Wu, Yue-Peng</creatorcontrib><creatorcontrib>Cocksedge, Karen A</creatorcontrib><creatorcontrib>Fu, Yong-Shui</creatorcontrib><creatorcontrib>Kong, Qing-Yu</creatorcontrib><creatorcontrib>Yao, Shu-Zhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive biomedicine online</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qiong</au><au>Li, Tin-Chu</au><au>Wu, Yue-Peng</au><au>Cocksedge, Karen A</au><au>Fu, Yong-Shui</au><au>Kong, Qing-Yu</au><au>Yao, Shu-Zhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reappraisal of peripheral NK cells in women with recurrent miscarriage</atitle><jtitle>Reproductive biomedicine online</jtitle><addtitle>Reprod Biomed Online</addtitle><date>2008</date><risdate>2008</risdate><volume>17</volume><issue>6</issue><spage>814</spage><epage>819</epage><pages>814-819</pages><issn>1472-6483</issn><eissn>1472-6491</eissn><abstract>Abstract The aim of this study was to examine the relationship between peripheral natural killer (NK) cells and recurrent miscarriage by improved methods. Peripheral NK cell measurement was carried out using flow cytometry of morning blood samples obtained in the early follicular phase, analysed within 8 h of collection. Eighty-five Chinese women with recurrent miscarriage who previously tested negative for autoantibodies, and 27 control subjects who were not using any hormonal methods for contraception, were recruited. No significant difference was found in the number of peripheral NK cells and their subsets between women with recurrent miscarriages and control subjects. Only 5% of women with recurrent miscarriage had high peripheral NK cells. The number of previous miscarriages did not appear to have an impact on the number of NK cells. In conclusion, there appears to be limited value in the routine measurement of peripheral NK cells in women with recurrent miscarriage.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>19079966</pmid><doi>10.1016/S1472-6483(10)60410-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Abortion, Habitual - blood Abortion, Habitual - ethnology Adult Autoantibodies - metabolism Case-Control Studies CD56 Antigen - biosynthesis Cell Proliferation China ethnicity Female Flow Cytometry - methods Humans Killer Cells, Natural - cytology Lewis X Antigen - biosynthesis Obstetrics and Gynecology peripheral NK cells Pregnancy recurrent miscarriage Reproducibility of Results Uterus - metabolism |
| title | Reappraisal of peripheral NK cells in women with recurrent miscarriage |
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