Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA

Genetic deficiencies of the complement protein C3 occur naturally in humans and animal models and have been induced in mice by targeted deletion of the C3 gene. The study of these deficiencies has provided evidence for C3 functions in immune responses. C3 deficient mice were generated by replacing t...

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Veröffentlicht in:Immunopharmacology 1999-05, Vol.42 (1-3), p.135-149
Hauptverfasser: Circolo, Antonella, Garnier, Gérard, Fukuda, Wataru, Wang, Xeufeng, Hidvegi, Tünde, Szalai, Alexander J, Briles, David E, Volanakis, John E, Wetsel, Rick A, Colten, Harvey R
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