SK3 K+ channel‐deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors

SK3 K+ channels influence neuronal excitability and are present in 5‐hydroxytryptamine (5‐HT) and dopamine (DA) nuclei in the brain stem. We therefore hypothesized that SK3 channels affect 5‐HT and DA neurotransmission and associated behaviors. To explore this, we used doxycycline‐induced conditiona...

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Veröffentlicht in:	Genes, brain and behavior brain and behavior, 2008-11, Vol.7 (8), p.836-848
Hauptverfasser:	Jacobsen, J. P. R., Weikop, P., Hansen, H. H., Mikkelsen, J. D., Redrobe, J. P., Holst, D., Bond, C. T., Adelman, J. P., Christophersen, P., Mirza, N. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antidepressant‐like anxiety Anxiety Disorders - genetics Anxiety Disorders - metabolism Anxiety Disorders - physiopathology Behavior, Animal - physiology Brain - metabolism Citalopram - pharmacology depression Dopamine - metabolism doxycycline Doxycycline - pharmacology Emotions - physiology Exploratory Behavior - physiology Female Hydroxyindoleacetic Acid - metabolism locomotor Male Mice Mice, Inbred C57BL Mice, Knockout Neurocognitive Disorders - genetics Neurocognitive Disorders - metabolism Neurocognitive Disorders - physiopathology Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - drug effects Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin Uptake Inhibitors - pharmacology Sex Characteristics Small-Conductance Calcium-Activated Potassium Channels - genetics Synaptic Transmission - genetics
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