Combination radioimmunotherapy with local hyperthermia: increased delivery of radioimmunoconjugate by vascular effect and its retention by increased antigen expression in colon cancer xenografts

Hyperthermia (HT) may increase tumor targeting of a radiolabeled antibody by its effects on tumor vasculature and antigen expression. Expression of a 45-kDa glycoprotein antigen on LS180 colon cancer cells was 2.7-fold enhanced 2 days after heating at 43°C for 1 h. Preferential tumor accumulation of...

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Veröffentlicht in:	Cancer letters 1999-06, Vol.140 (1), p.209-218
Hauptverfasser:	Kinuya, Seigo, Yokoyama, Kunihiko, Hiramatsu, Takashi, Tega, Harunobu, Tanaka, Kazuhiro, Konishi, Shota, Shuke, Noriyuki, Aburano, Tamio, Watanabe, Naoto, Takayama, Teruhiko, Michigishi, Takatoshi, Tonami, Norihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antigen expression Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - immunology Antineoplastic agents Biological and medical sciences Chromatography, High Pressure Liquid Colonic Neoplasms - blood supply Colonic Neoplasms - therapy Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Female Humans Hyperthermia Hyperthermia, Induced Immunoconjugates - pharmacokinetics Immunoconjugates - therapeutic use Iodine Radioisotopes Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Transplantation Pharmacology. Drug treatments Radioimmunotherapy Time Factors Tissue Distribution Transplantation, Heterologous Tumor blood flow Tumor Cells, Cultured Vascular permeability
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