Protection against endogenous and UVB-induced oxidative damage in stratum corneum lipids by an antioxidant-containing cosmetic formulation
A 16‐week human clinical study was carried out to determine the ability of antioxidants in a cosmetic vehicle to inhibit the induction of lipid peroxidation in stratum corneum lipids. The study consisted of a twice daily application of material for 12 weeks followed by a 4‐week regression phase. Str...
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| Veröffentlicht in: | Photodermatology photoimmunology & photomedicine 1999-06, Vol.15 (3-4), p.115-119 |
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| container_title | Photodermatology photoimmunology & photomedicine |
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| creator | Pelle, E. Muizzuddin, N. Mammone, T. Marenus, K. Maes, D. |
| description | A 16‐week human clinical study was carried out to determine the ability of antioxidants in a cosmetic vehicle to inhibit the induction of lipid peroxidation in stratum corneum lipids. The study consisted of a twice daily application of material for 12 weeks followed by a 4‐week regression phase. Stratum corneum lipids were collected and then exposed to 500 mJ/cm2 of ultraviolet B (UVB) radiation in order to avoid excessive erythemal damage to the subjects. Lipid peroxides were assayed by a methylene blue derivative assay and expressed per unit area of skin. During the treatment period, decreases in the level of lipid peroxides were observed on the sites treated with the compositions containing antioxidants, as compared to the untreated sites, and expressed as percent differences. Decreases were observed in endogenous as well as UV‐induced lipid peroxides followed by a return to baseline levels. These results demonstrate that antioxidants in a topical cosmetic formulation were effective in protecting human stratum corneum lipids against endogenous oxidation or if challenged by 500 mJ/cm2 UVB. |
| doi_str_mv | 10.1111/j.1600-0781.1999.tb00070.x |
| format | Article |
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The study consisted of a twice daily application of material for 12 weeks followed by a 4‐week regression phase. Stratum corneum lipids were collected and then exposed to 500 mJ/cm2 of ultraviolet B (UVB) radiation in order to avoid excessive erythemal damage to the subjects. Lipid peroxides were assayed by a methylene blue derivative assay and expressed per unit area of skin. During the treatment period, decreases in the level of lipid peroxides were observed on the sites treated with the compositions containing antioxidants, as compared to the untreated sites, and expressed as percent differences. Decreases were observed in endogenous as well as UV‐induced lipid peroxides followed by a return to baseline levels. These results demonstrate that antioxidants in a topical cosmetic formulation were effective in protecting human stratum corneum lipids against endogenous oxidation or if challenged by 500 mJ/cm2 UVB.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/j.1600-0781.1999.tb00070.x</identifier><identifier>PMID: 10404721</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>antioxidants ; Antioxidants - administration & dosage ; Antioxidants - pharmacology ; Biological and medical sciences ; Cosmetics ; Diseases of the skin. Cosmetics ; Epidermis - drug effects ; Epidermis - metabolism ; Epidermis - radiation effects ; Female ; Humans ; Lipid Metabolism ; Lipid Peroxidation - drug effects ; Lipid Peroxidation - radiation effects ; lipid peroxides ; Lipids - radiation effects ; Medical sciences ; Oxidative Stress ; Radiotherapy. Instrumental treatment. Physiotherapy. 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The study consisted of a twice daily application of material for 12 weeks followed by a 4‐week regression phase. Stratum corneum lipids were collected and then exposed to 500 mJ/cm2 of ultraviolet B (UVB) radiation in order to avoid excessive erythemal damage to the subjects. Lipid peroxides were assayed by a methylene blue derivative assay and expressed per unit area of skin. During the treatment period, decreases in the level of lipid peroxides were observed on the sites treated with the compositions containing antioxidants, as compared to the untreated sites, and expressed as percent differences. Decreases were observed in endogenous as well as UV‐induced lipid peroxides followed by a return to baseline levels. These results demonstrate that antioxidants in a topical cosmetic formulation were effective in protecting human stratum corneum lipids against endogenous oxidation or if challenged by 500 mJ/cm2 UVB.</description><subject>antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cosmetics</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Epidermis - drug effects</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - radiation effects</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid Metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid Peroxidation - radiation effects</subject><subject>lipid peroxides</subject><subject>Lipids - radiation effects</subject><subject>Medical sciences</subject><subject>Oxidative Stress</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>skin</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>UVB</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkdGO1CAUhonRuOPqKxhijHet0FIo3hh3orvGdZ2LVRNvCAU6YWxhBKozr-BTS9PJ6q2E5Fzw_f_hPweAZxiVOJ-XuxJThArEWlxiznmZOoQQQ-XhHljdPd0HK8RRU5C6rc_Aoxh3GSIE4YfgDCOCCKvwCvzeBJ-MStY7KLfSupigcdpvjfNThNJp-PnLRWGdnpTR0B-slsn-NFDLUW4NtA7GFGSaRqh8cCbXwe6tjrA7ZnW-2XoWuVQo71LuYN02s3E0ySrY-zBOg5z7PwYPejlE8-RUz8Htu7e366vi-tPl-_Wb60LlKDkPlY3ilNGKMqYVokwbxPuOdFJSUsnKyIZoxJUhmDFMmpZiw6uG5_QtwvU5eLHY7oP_MZmYxGijMsMgncmRBeVtSwkmGXy1gCr4GIPpxT7YUYajwEjMixA7MU9bzNMW8yLEaRHikMVPT12mbjT6H-ky-Qw8PwEyKjn0QTpl41-urSuG64y9XrBfdjDH__iB2FxtNhg32aFYHGxM5nDnIMN3QVnNGvH15lKsv918oPUFEh_rP53ptro</recordid><startdate>199906</startdate><enddate>199906</enddate><creator>Pelle, E.</creator><creator>Muizzuddin, N.</creator><creator>Mammone, T.</creator><creator>Marenus, K.</creator><creator>Maes, D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199906</creationdate><title>Protection against endogenous and UVB-induced oxidative damage in stratum corneum lipids by an antioxidant-containing cosmetic formulation</title><author>Pelle, E. ; Muizzuddin, N. ; Mammone, T. ; Marenus, K. ; Maes, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4385-46a5c96762677dc067de09fb4baa642a2ea54d09ce4177145861e92590048013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cosmetics</topic><topic>Diseases of the skin. Cosmetics</topic><topic>Epidermis - drug effects</topic><topic>Epidermis - metabolism</topic><topic>Epidermis - radiation effects</topic><topic>Female</topic><topic>Humans</topic><topic>Lipid Metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid Peroxidation - radiation effects</topic><topic>lipid peroxides</topic><topic>Lipids - radiation effects</topic><topic>Medical sciences</topic><topic>Oxidative Stress</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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The study consisted of a twice daily application of material for 12 weeks followed by a 4‐week regression phase. Stratum corneum lipids were collected and then exposed to 500 mJ/cm2 of ultraviolet B (UVB) radiation in order to avoid excessive erythemal damage to the subjects. Lipid peroxides were assayed by a methylene blue derivative assay and expressed per unit area of skin. During the treatment period, decreases in the level of lipid peroxides were observed on the sites treated with the compositions containing antioxidants, as compared to the untreated sites, and expressed as percent differences. Decreases were observed in endogenous as well as UV‐induced lipid peroxides followed by a return to baseline levels. 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| ispartof | Photodermatology photoimmunology & photomedicine, 1999-06, Vol.15 (3-4), p.115-119 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | antioxidants Antioxidants - administration & dosage Antioxidants - pharmacology Biological and medical sciences Cosmetics Diseases of the skin. Cosmetics Epidermis - drug effects Epidermis - metabolism Epidermis - radiation effects Female Humans Lipid Metabolism Lipid Peroxidation - drug effects Lipid Peroxidation - radiation effects lipid peroxides Lipids - radiation effects Medical sciences Oxidative Stress Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) skin Ultraviolet Rays - adverse effects UVB |
| title | Protection against endogenous and UVB-induced oxidative damage in stratum corneum lipids by an antioxidant-containing cosmetic formulation |
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