Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis
In the present study we evaluated the effects of an intracerebroventricular injection of streptozotocin on cognitive behavior and biochemical markers in the brain of middle-aged Wistar rats. Intracerebroventricular injected streptozotocin has previously been reported to decrease the central metaboli...
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| Veröffentlicht in: | Behavioural brain research 1999-07, Vol.102 (1), p.73-88 |
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| description | In the present study we evaluated the effects of an intracerebroventricular injection of streptozotocin on cognitive behavior and biochemical markers in the brain of middle-aged Wistar rats. Intracerebroventricular injected streptozotocin has previously been reported to decrease the central metabolism of glucose. We found that streptozotocin-treated rats showed an impaired cognitive performance in the delayed non-matching to position task and the Morris water escape task. Glial fibrillary acidic protein, an indicator of reactive astroglial changes, was measured in three different (soluble, Triton X-100 soluble and crude cytoskeletal) protein fractions and its content in the fractions of the septum, hippocampus and striatum of streptozotocin-treated rats was increased. Furthermore, the glial fibrillary acidic protein response of each protein fraction to streptozotocin treatment appeared to be differently regulated. In streptozotocin-treated rats the choline acetyltransferase activity was decreased in the hippocampus only, which was correlated with the hippocampal glial fibrillary acidic protein contents of all three hippocampal protein fractions, thus suggesting that the cholinergic deficit is a consequence of direct damage to the hippocampus. The cognitive deficits in both tasks were related to the increased glial fibrillary acidic protein contents, especially of the soluble and cytoskeletal fraction, and the decreased choline acetyltransferase activity in the hippocampus. Taken together, these findings indicate that it is important to take into account which protein fraction has been used for measuring the glial fibrillary acidic protein response to a stressor. Furthermore, intracerebroventricular injected streptozotocin may provide a relevant model for studying neurodegenerative changes due to a metabolic insufficiency and testing neuroprotective effects of substances. |
| doi_str_mv | 10.1016/S0166-4328(98)00158-2 |
| format | Article |
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Intracerebroventricular injected streptozotocin has previously been reported to decrease the central metabolism of glucose. We found that streptozotocin-treated rats showed an impaired cognitive performance in the delayed non-matching to position task and the Morris water escape task. Glial fibrillary acidic protein, an indicator of reactive astroglial changes, was measured in three different (soluble, Triton X-100 soluble and crude cytoskeletal) protein fractions and its content in the fractions of the septum, hippocampus and striatum of streptozotocin-treated rats was increased. Furthermore, the glial fibrillary acidic protein response of each protein fraction to streptozotocin treatment appeared to be differently regulated. In streptozotocin-treated rats the choline acetyltransferase activity was decreased in the hippocampus only, which was correlated with the hippocampal glial fibrillary acidic protein contents of all three hippocampal protein fractions, thus suggesting that the cholinergic deficit is a consequence of direct damage to the hippocampus. The cognitive deficits in both tasks were related to the increased glial fibrillary acidic protein contents, especially of the soluble and cytoskeletal fraction, and the decreased choline acetyltransferase activity in the hippocampus. Taken together, these findings indicate that it is important to take into account which protein fraction has been used for measuring the glial fibrillary acidic protein response to a stressor. Furthermore, intracerebroventricular injected streptozotocin may provide a relevant model for studying neurodegenerative changes due to a metabolic insufficiency and testing neuroprotective effects of substances.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/S0166-4328(98)00158-2</identifier><identifier>PMID: 10403017</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Alzheimer’s disease ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Blood Glucose - metabolism ; Brain Mapping ; Choline acetyltransferase ; Choline O-Acetyltransferase - metabolism ; Corpus Striatum - drug effects ; Escape Reaction - drug effects ; Fundamental and applied biological sciences. Psychology ; Glial fibrillary acidic protein ; Glial Fibrillary Acidic Protein - metabolism ; Hippocampus - drug effects ; Injections, Intraventricular ; Male ; Maze Learning - drug effects ; Memory ; Mental Recall - drug effects ; Miscellaneous ; Orientation - drug effects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Retention (Psychology) - drug effects ; Septum Pellucidum - drug effects ; Streptozocin - pharmacology ; Streptozotocin</subject><ispartof>Behavioural brain research, 1999-07, Vol.102 (1), p.73-88</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-26aca9aebb05e6f18c8d0f76272c6b30b11d5bf5927e408db58cccc8f383f7653</citedby><cites>FETCH-LOGICAL-c539t-26aca9aebb05e6f18c8d0f76272c6b30b11d5bf5927e408db58cccc8f383f7653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432898001582$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1852288$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10403017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prickaerts, Jos</creatorcontrib><creatorcontrib>Fahrig, Thomas</creatorcontrib><creatorcontrib>Blokland, Arjan</creatorcontrib><title>Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>In the present study we evaluated the effects of an intracerebroventricular injection of streptozotocin on cognitive behavior and biochemical markers in the brain of middle-aged Wistar rats. Intracerebroventricular injected streptozotocin has previously been reported to decrease the central metabolism of glucose. We found that streptozotocin-treated rats showed an impaired cognitive performance in the delayed non-matching to position task and the Morris water escape task. Glial fibrillary acidic protein, an indicator of reactive astroglial changes, was measured in three different (soluble, Triton X-100 soluble and crude cytoskeletal) protein fractions and its content in the fractions of the septum, hippocampus and striatum of streptozotocin-treated rats was increased. Furthermore, the glial fibrillary acidic protein response of each protein fraction to streptozotocin treatment appeared to be differently regulated. In streptozotocin-treated rats the choline acetyltransferase activity was decreased in the hippocampus only, which was correlated with the hippocampal glial fibrillary acidic protein contents of all three hippocampal protein fractions, thus suggesting that the cholinergic deficit is a consequence of direct damage to the hippocampus. The cognitive deficits in both tasks were related to the increased glial fibrillary acidic protein contents, especially of the soluble and cytoskeletal fraction, and the decreased choline acetyltransferase activity in the hippocampus. Taken together, these findings indicate that it is important to take into account which protein fraction has been used for measuring the glial fibrillary acidic protein response to a stressor. Furthermore, intracerebroventricular injected streptozotocin may provide a relevant model for studying neurodegenerative changes due to a metabolic insufficiency and testing neuroprotective effects of substances.</description><subject>Alzheimer’s disease</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Brain Mapping</subject><subject>Choline acetyltransferase</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Corpus Striatum - drug effects</subject><subject>Escape Reaction - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glial fibrillary acidic protein</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Memory</subject><subject>Mental Recall - drug effects</subject><subject>Miscellaneous</subject><subject>Orientation - drug effects</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Retention (Psychology) - drug effects</subject><subject>Septum Pellucidum - drug effects</subject><subject>Streptozocin - pharmacology</subject><subject>Streptozotocin</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV-P1CAQwInReHunH0HDgzGa2BVoaakvxmz8l1zig_pMKB28OdtSgW5yfhe_69Hdjfp2PABhfjND5kfIE862nPH69de81UVVCvWiVS8Z41IV4h7ZcNWIopFVe59s_iJn5DzGa8ZYxSR_SM54vpSMNxvyZ-d_TJhwD3SG4HwYzWSBmqmnHXp7BSNaM9DRhJ8QIsWJRpjTMr6iVzjP3ppxXuIBjymgyRHqHQ0m5UeXIOQQxa3d7rc59xpsQj-tRKZzHf_bJ29xekMNtT4EGMwBMJMZbiLGR-SBM0OEx6fzgnz_8P7b7lNx-eXj5927y8LKsk2FqI01rYGuYxJqx5VVPXNNLRph665kHee97JxsRQMVU30nlc1LuVKVGZPlBXl-rDsH_2uBmPSI0cIwmAn8EnXdKiUbJu4EeSNaWVYqg_II2uBjDOD0HDBP8UZzpleB-iBQr3Z0q_RBoF4bPD01WLoR-v-yjsYy8OwEmJjNuJB9YfzHKSmEWvu_PWKQx7ZHCDpahKy2x5At6N7jHT-5BX3euvY</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Prickaerts, Jos</creator><creator>Fahrig, Thomas</creator><creator>Blokland, Arjan</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis</title><author>Prickaerts, Jos ; Fahrig, Thomas ; Blokland, Arjan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-26aca9aebb05e6f18c8d0f76272c6b30b11d5bf5927e408db58cccc8f383f7653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Alzheimer’s disease</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Brain Mapping</topic><topic>Choline acetyltransferase</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Corpus Striatum - drug effects</topic><topic>Escape Reaction - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glial fibrillary acidic protein</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Memory</topic><topic>Mental Recall - drug effects</topic><topic>Miscellaneous</topic><topic>Orientation - drug effects</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Retention (Psychology) - drug effects</topic><topic>Septum Pellucidum - drug effects</topic><topic>Streptozocin - pharmacology</topic><topic>Streptozotocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prickaerts, Jos</creatorcontrib><creatorcontrib>Fahrig, Thomas</creatorcontrib><creatorcontrib>Blokland, Arjan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prickaerts, Jos</au><au>Fahrig, Thomas</au><au>Blokland, Arjan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>102</volume><issue>1</issue><spage>73</spage><epage>88</epage><pages>73-88</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>In the present study we evaluated the effects of an intracerebroventricular injection of streptozotocin on cognitive behavior and biochemical markers in the brain of middle-aged Wistar rats. Intracerebroventricular injected streptozotocin has previously been reported to decrease the central metabolism of glucose. We found that streptozotocin-treated rats showed an impaired cognitive performance in the delayed non-matching to position task and the Morris water escape task. Glial fibrillary acidic protein, an indicator of reactive astroglial changes, was measured in three different (soluble, Triton X-100 soluble and crude cytoskeletal) protein fractions and its content in the fractions of the septum, hippocampus and striatum of streptozotocin-treated rats was increased. Furthermore, the glial fibrillary acidic protein response of each protein fraction to streptozotocin treatment appeared to be differently regulated. In streptozotocin-treated rats the choline acetyltransferase activity was decreased in the hippocampus only, which was correlated with the hippocampal glial fibrillary acidic protein contents of all three hippocampal protein fractions, thus suggesting that the cholinergic deficit is a consequence of direct damage to the hippocampus. The cognitive deficits in both tasks were related to the increased glial fibrillary acidic protein contents, especially of the soluble and cytoskeletal fraction, and the decreased choline acetyltransferase activity in the hippocampus. Taken together, these findings indicate that it is important to take into account which protein fraction has been used for measuring the glial fibrillary acidic protein response to a stressor. Furthermore, intracerebroventricular injected streptozotocin may provide a relevant model for studying neurodegenerative changes due to a metabolic insufficiency and testing neuroprotective effects of substances.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>10403017</pmid><doi>10.1016/S0166-4328(98)00158-2</doi><tpages>16</tpages></addata></record> |
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| ispartof | Behavioural brain research, 1999-07, Vol.102 (1), p.73-88 |
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| subjects | Alzheimer’s disease Animals Behavioral psychophysiology Biological and medical sciences Blood Glucose - metabolism Brain Mapping Choline acetyltransferase Choline O-Acetyltransferase - metabolism Corpus Striatum - drug effects Escape Reaction - drug effects Fundamental and applied biological sciences. Psychology Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Hippocampus - drug effects Injections, Intraventricular Male Maze Learning - drug effects Memory Mental Recall - drug effects Miscellaneous Orientation - drug effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Retention (Psychology) - drug effects Septum Pellucidum - drug effects Streptozocin - pharmacology Streptozotocin |
| title | Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis |
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