Intracellular Signalling Pathways Induced by Chemokines in Natural Killer Cells
Chemokines are small peptides involved in the recruitment of various cell types into inflammatory sites. They are divided into four sub-families depending on the presence of amino acids separating the cysteine residues in their N-terminal region. These are the α (CXC), β (CC), γ (C) and δ (CX 3C) ch...
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Veröffentlicht in: | Cellular Signalling 1999-06, Vol.11 (6), p.385-390 |
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description | Chemokines are small peptides involved in the recruitment of various cell types into inflammatory sites. They are divided into four sub-families depending on the presence of amino acids separating the cysteine residues in their N-terminal region. These are the α (CXC), β (CC), γ (C) and δ (CX
3C) chemokines. In addition, five CXC chemokine (CXCR1–5), nine CC chemokine (CCR1–9), one C chemokine (XCR1) and one CX
3C chemokine (CX
3CR1) receptors have been identified. These receptors belong to the seven transmembrane spanning domain family, and are coupled to the heterotrimeric guanine nucleotide binding (G) proteins. Chemokines activate various immune cells, and in particular the anti-viral/anti-tumour effectors, the natural killer (NK) cells by activating members of the heterotrimeric G proteins. The importance of the family of chemokines is highlighted by the ability of its members to inhibit the replication of HIV-1 strains in CD4
+ cells, where chemokine receptors act as HIV-1 co-receptors. This review discusses the intracellular signalling pathways induced by chemokines in NK and other cell types, and the relationships to HIV-1 signalling in these cells. |
doi_str_mv | 10.1016/S0898-6568(99)00008-X |
format | Article |
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3C) chemokines. In addition, five CXC chemokine (CXCR1–5), nine CC chemokine (CCR1–9), one C chemokine (XCR1) and one CX
3C chemokine (CX
3CR1) receptors have been identified. These receptors belong to the seven transmembrane spanning domain family, and are coupled to the heterotrimeric guanine nucleotide binding (G) proteins. Chemokines activate various immune cells, and in particular the anti-viral/anti-tumour effectors, the natural killer (NK) cells by activating members of the heterotrimeric G proteins. The importance of the family of chemokines is highlighted by the ability of its members to inhibit the replication of HIV-1 strains in CD4
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3C) chemokines. In addition, five CXC chemokine (CXCR1–5), nine CC chemokine (CCR1–9), one C chemokine (XCR1) and one CX
3C chemokine (CX
3CR1) receptors have been identified. These receptors belong to the seven transmembrane spanning domain family, and are coupled to the heterotrimeric guanine nucleotide binding (G) proteins. Chemokines activate various immune cells, and in particular the anti-viral/anti-tumour effectors, the natural killer (NK) cells by activating members of the heterotrimeric G proteins. The importance of the family of chemokines is highlighted by the ability of its members to inhibit the replication of HIV-1 strains in CD4
+ cells, where chemokine receptors act as HIV-1 co-receptors. This review discusses the intracellular signalling pathways induced by chemokines in NK and other cell types, and the relationships to HIV-1 signalling in these cells.</description><subject>AIDS/HIV</subject><subject>Chemokine receptors</subject><subject>Chemokines</subject><subject>Chemokines - metabolism</subject><subject>G proteins</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>HIV-1</subject><subject>HIV-1 - metabolism</subject><subject>Humans</subject><subject>Intracellular Fluid - metabolism</subject><subject>Killer Cells, Natural - metabolism</subject><subject>NK Cells</subject><subject>Receptor desensitisation</subject><subject>Receptors, Chemokine - metabolism</subject><subject>Signal Transduction</subject><subject>Signalling pathways</subject><issn>0898-6568</issn><issn>1873-3913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EgvL4BJBXCBaBsdPE9gqhikcFAqSC1J3lOBMwuEmxE1D_npQixI7ZzObMXN1DyD6DEwYsP52AVDLJs1weKXUM_chkukYGTIo0SRVL18ngF9ki2zG-ArAMcr5JthgMAVLGBuR-XLfBWPS-8ybQiXuujfeufqYPpn35NItIx3XZWSxpsaCjF5w1b67GSF1N70zbBePpjfMeAx31T-Iu2aiMj7j3s3fI0-XF4-g6ub2_Go_ObxOb5qxNhLIm5cJaa4RUUFrgFS9yxSsQZcYqTDNgYBhH5ApExrksmWBlIcywymWR7pDD1d95aN47jK2eubisYWpsuqhzJeVQiWEPZivQhibGgJWeBzczYaEZ6KVJ_W1SLzVppfS3ST3t7w5-ArpihuWfq5W6HjhbAdjX_HAYdLQO696UC2hbXTbun4gvEVWDNQ</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Maghazachi, Azzam A</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990601</creationdate><title>Intracellular Signalling Pathways Induced by Chemokines in Natural Killer Cells</title><author>Maghazachi, Azzam A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-79ca327ccca7890dc02f2b692f07d51fe35010a12ee29075228d171db7a4f68b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AIDS/HIV</topic><topic>Chemokine receptors</topic><topic>Chemokines</topic><topic>Chemokines - metabolism</topic><topic>G proteins</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>HIV-1</topic><topic>HIV-1 - metabolism</topic><topic>Humans</topic><topic>Intracellular Fluid - metabolism</topic><topic>Killer Cells, Natural - metabolism</topic><topic>NK Cells</topic><topic>Receptor desensitisation</topic><topic>Receptors, Chemokine - metabolism</topic><topic>Signal Transduction</topic><topic>Signalling pathways</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maghazachi, Azzam A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular Signalling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maghazachi, Azzam A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracellular Signalling Pathways Induced by Chemokines in Natural Killer Cells</atitle><jtitle>Cellular Signalling</jtitle><addtitle>Cell Signal</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>11</volume><issue>6</issue><spage>385</spage><epage>390</epage><pages>385-390</pages><issn>0898-6568</issn><eissn>1873-3913</eissn><abstract>Chemokines are small peptides involved in the recruitment of various cell types into inflammatory sites. They are divided into four sub-families depending on the presence of amino acids separating the cysteine residues in their N-terminal region. These are the α (CXC), β (CC), γ (C) and δ (CX
3C) chemokines. In addition, five CXC chemokine (CXCR1–5), nine CC chemokine (CCR1–9), one C chemokine (XCR1) and one CX
3C chemokine (CX
3CR1) receptors have been identified. These receptors belong to the seven transmembrane spanning domain family, and are coupled to the heterotrimeric guanine nucleotide binding (G) proteins. Chemokines activate various immune cells, and in particular the anti-viral/anti-tumour effectors, the natural killer (NK) cells by activating members of the heterotrimeric G proteins. The importance of the family of chemokines is highlighted by the ability of its members to inhibit the replication of HIV-1 strains in CD4
+ cells, where chemokine receptors act as HIV-1 co-receptors. This review discusses the intracellular signalling pathways induced by chemokines in NK and other cell types, and the relationships to HIV-1 signalling in these cells.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>10400311</pmid><doi>10.1016/S0898-6568(99)00008-X</doi><tpages>6</tpages></addata></record> |
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subjects | AIDS/HIV Chemokine receptors Chemokines Chemokines - metabolism G proteins GTP-Binding Proteins - metabolism HIV-1 HIV-1 - metabolism Humans Intracellular Fluid - metabolism Killer Cells, Natural - metabolism NK Cells Receptor desensitisation Receptors, Chemokine - metabolism Signal Transduction Signalling pathways |
title | Intracellular Signalling Pathways Induced by Chemokines in Natural Killer Cells |
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