Obstetric complications predict treatment response in first-episode schizophrenia
Background. Understanding the role of obstetric complications (OCs) in schizophrenia could potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many investigators have reported an association between OCs and schizophrenia, but few have examined the association be...
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| Veröffentlicht in: | Psychological medicine 1999-05, Vol.29 (3), p.621-627 |
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| creator | ALVIR, J. M. J. WOERNER, M. G. GUNDUZ, H. DEGREEF, G. LIEBERMAN, J. A. |
| description | Background. Understanding the role of obstetric complications (OCs) in schizophrenia could
potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many
investigators have reported an association between OCs and schizophrenia, but few have examined
the association between OCs and treatment outcome. We investigated this question in a sample of
patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform
disorder. Method. OC histories were obtained for 59 patients participating in the Hillside First Episode Study.
Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment
response during the first episode of schizophrenia. Results. Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower
rates of treatment response than those with negative OC histories (hazard ratio controlling for sex
= 0·28; 95% CI = 0·13, 0·62). The positive OC group also had significantly greater lateral ventricle
volume, baseline disorganization and number of live births. The effect of OC history on treatment
response held when these three variables were controlled for. Conclusion. A history of obstetric complications predicted poor response to treatment in the first
episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus,
replication is called for. |
| doi_str_mv | 10.1017/S0033291799008363 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69883767</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0033291799008363</cupid><sourcerecordid>69883767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-566507770c2889ec2c9c6ed940d2e5cd8bc8c2e66924061f719dbbf5d5abc7df3</originalsourceid><addsrcrecordid>eNqFkUtvFDEQhC0EIkvgB3BBc0Dchtjj8euIAixIiaLloRwtT7uHOMwrtlci-fXxalcQCQlOfaivSt3VhLxk9C2jTJ18pZTzxjBlDKWaS_6IrFgrTa2N0o_JaifXO_2IPEvpmlLGWds8JUeMtlQUx4psLrqUMccAFczjMgRwOcxTqpaIPkCuckSXR5xyFTEtRcEqTFUfYso1LiHNHqsEV-FuXq4iTsE9J096NyR8cZjH5PvHD99OP9VnF-vPp-_Oami5ybWQUlClFIVGa4PQgAGJ3rTUNyjA6w40NCilaVoqWa-Y8V3XCy9cB8r3_Ji82ecucb7ZYsp2DAlwGNyE8zZZabTmSqr_gkJJ2TChC8j2IMQ5pYi9XWIYXby1jNpd4favwovn1SF8243oHzj2DRfg9QFwCdzQRzdBSH843ZpG0oLVeyyUd_z6Lbv405YTlLByvbHnm7X-csnf28vC88Oubuxi8D_QXs_bOJXG_7HtPflKp7A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>57662158</pqid></control><display><type>article</type><title>Obstetric complications predict treatment response in first-episode schizophrenia</title><source>MEDLINE</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><source>Cambridge University Press Journals Complete</source><creator>ALVIR, J. M. J. ; WOERNER, M. G. ; GUNDUZ, H. ; DEGREEF, G. ; LIEBERMAN, J. A.</creator><creatorcontrib>ALVIR, J. M. J. ; WOERNER, M. G. ; GUNDUZ, H. ; DEGREEF, G. ; LIEBERMAN, J. A.</creatorcontrib><description>Background. Understanding the role of obstetric complications (OCs) in schizophrenia could
potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many
investigators have reported an association between OCs and schizophrenia, but few have examined
the association between OCs and treatment outcome. We investigated this question in a sample of
patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform
disorder. Method. OC histories were obtained for 59 patients participating in the Hillside First Episode Study.
Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment
response during the first episode of schizophrenia. Results. Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower
rates of treatment response than those with negative OC histories (hazard ratio controlling for sex
= 0·28; 95% CI = 0·13, 0·62). The positive OC group also had significantly greater lateral ventricle
volume, baseline disorganization and number of live births. The effect of OC history on treatment
response held when these three variables were controlled for. Conclusion. A history of obstetric complications predicted poor response to treatment in the first
episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus,
replication is called for.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291799008363</identifier><identifier>PMID: 10405083</identifier><identifier>CODEN: PSMDCO</identifier><language>eng</language><publisher>Cambridge: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Complications ; Factors ; Female ; Humans ; Male ; Medical sciences ; Obstetric Labor Complications - diagnosis ; Obstetrics ; Patients ; Pregnancy ; Prognosis ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Responses ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Time Factors ; Treatment ; Treatment Outcome</subject><ispartof>Psychological medicine, 1999-05, Vol.29 (3), p.621-627</ispartof><rights>1999 Cambridge University Press</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-566507770c2889ec2c9c6ed940d2e5cd8bc8c2e66924061f719dbbf5d5abc7df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291799008363/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,27924,27925,31000,55628</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1849260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10405083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALVIR, J. M. J.</creatorcontrib><creatorcontrib>WOERNER, M. G.</creatorcontrib><creatorcontrib>GUNDUZ, H.</creatorcontrib><creatorcontrib>DEGREEF, G.</creatorcontrib><creatorcontrib>LIEBERMAN, J. A.</creatorcontrib><title>Obstetric complications predict treatment response in first-episode schizophrenia</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Background. Understanding the role of obstetric complications (OCs) in schizophrenia could
potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many
investigators have reported an association between OCs and schizophrenia, but few have examined
the association between OCs and treatment outcome. We investigated this question in a sample of
patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform
disorder. Method. OC histories were obtained for 59 patients participating in the Hillside First Episode Study.
Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment
response during the first episode of schizophrenia. Results. Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower
rates of treatment response than those with negative OC histories (hazard ratio controlling for sex
= 0·28; 95% CI = 0·13, 0·62). The positive OC group also had significantly greater lateral ventricle
volume, baseline disorganization and number of live births. The effect of OC history on treatment
response held when these three variables were controlled for. Conclusion. A history of obstetric complications predicted poor response to treatment in the first
episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus,
replication is called for.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Complications</subject><subject>Factors</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obstetric Labor Complications - diagnosis</subject><subject>Obstetrics</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Prognosis</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Responses</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Time Factors</subject><subject>Treatment</subject><subject>Treatment Outcome</subject><issn>0033-2917</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkUtvFDEQhC0EIkvgB3BBc0Dchtjj8euIAixIiaLloRwtT7uHOMwrtlci-fXxalcQCQlOfaivSt3VhLxk9C2jTJ18pZTzxjBlDKWaS_6IrFgrTa2N0o_JaifXO_2IPEvpmlLGWds8JUeMtlQUx4psLrqUMccAFczjMgRwOcxTqpaIPkCuckSXR5xyFTEtRcEqTFUfYso1LiHNHqsEV-FuXq4iTsE9J096NyR8cZjH5PvHD99OP9VnF-vPp-_Oami5ybWQUlClFIVGa4PQgAGJ3rTUNyjA6w40NCilaVoqWa-Y8V3XCy9cB8r3_Ji82ecucb7ZYsp2DAlwGNyE8zZZabTmSqr_gkJJ2TChC8j2IMQ5pYi9XWIYXby1jNpd4favwovn1SF8243oHzj2DRfg9QFwCdzQRzdBSH843ZpG0oLVeyyUd_z6Lbv405YTlLByvbHnm7X-csnf28vC88Oubuxi8D_QXs_bOJXG_7HtPflKp7A</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>ALVIR, J. M. J.</creator><creator>WOERNER, M. G.</creator><creator>GUNDUZ, H.</creator><creator>DEGREEF, G.</creator><creator>LIEBERMAN, J. A.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>Obstetric complications predict treatment response in first-episode schizophrenia</title><author>ALVIR, J. M. J. ; WOERNER, M. G. ; GUNDUZ, H. ; DEGREEF, G. ; LIEBERMAN, J. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-566507770c2889ec2c9c6ed940d2e5cd8bc8c2e66924061f719dbbf5d5abc7df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Complications</topic><topic>Factors</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obstetric Labor Complications - diagnosis</topic><topic>Obstetrics</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Prognosis</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Responses</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Time Factors</topic><topic>Treatment</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALVIR, J. M. J.</creatorcontrib><creatorcontrib>WOERNER, M. G.</creatorcontrib><creatorcontrib>GUNDUZ, H.</creatorcontrib><creatorcontrib>DEGREEF, G.</creatorcontrib><creatorcontrib>LIEBERMAN, J. A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ALVIR, J. M. J.</au><au>WOERNER, M. G.</au><au>GUNDUZ, H.</au><au>DEGREEF, G.</au><au>LIEBERMAN, J. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstetric complications predict treatment response in first-episode schizophrenia</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>29</volume><issue>3</issue><spage>621</spage><epage>627</epage><pages>621-627</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><coden>PSMDCO</coden><abstract>Background. Understanding the role of obstetric complications (OCs) in schizophrenia could
potentially shed light on the heterogeneity in the aetiology and course of schizophrenia. Many
investigators have reported an association between OCs and schizophrenia, but few have examined
the association between OCs and treatment outcome. We investigated this question in a sample of
patients studied during their first episode of schizophrenia, schizoaffective or schizophreniform
disorder. Method. OC histories were obtained for 59 patients participating in the Hillside First Episode Study.
Cox proportional hazards regression analysis was used to estimate the effect of OCs on treatment
response during the first episode of schizophrenia. Results. Twelve of the 59 patients (20%) had positive histories of OCs. This group exhibited lower
rates of treatment response than those with negative OC histories (hazard ratio controlling for sex
= 0·28; 95% CI = 0·13, 0·62). The positive OC group also had significantly greater lateral ventricle
volume, baseline disorganization and number of live births. The effect of OC history on treatment
response held when these three variables were controlled for. Conclusion. A history of obstetric complications predicted poor response to treatment in the first
episode of schizophrenia. This large effect was based on a small sample of 59 patients. Thus,
replication is called for.</abstract><cop>Cambridge</cop><pub>Cambridge University Press</pub><pmid>10405083</pmid><doi>10.1017/S0033291799008363</doi><tpages>7</tpages></addata></record> |
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| ispartof | Psychological medicine, 1999-05, Vol.29 (3), p.621-627 |
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| source | MEDLINE; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Adolescent Adult Adult and adolescent clinical studies Antipsychotic Agents - therapeutic use Biological and medical sciences Complications Factors Female Humans Male Medical sciences Obstetric Labor Complications - diagnosis Obstetrics Patients Pregnancy Prognosis Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Responses Schizophrenia Schizophrenia - diagnosis Schizophrenia - drug therapy Time Factors Treatment Treatment Outcome |
| title | Obstetric complications predict treatment response in first-episode schizophrenia |
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