Disappearance curves for tumor markers after resection of intrathoracic malignancies
Determination of the standard elimination kinetics of tumor markers will be helpful in the diagnosis of malignancies. We analyzed the disappearance curves for serum tumor marker levels after resection of intrathoracic malignancies. Serum levels of CEA, SLX, AFP, CA 19-9, SCC, TPA and CYFRA were meas...
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| Veröffentlicht in: | The International journal of biological markers 1999-04, Vol.14 (2), p.99-105 |
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| container_title | The International journal of biological markers |
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| creator | YOSHIMASU, T MAEBEYA, S SUZUMA, T BESSHO, T TANINO, H ARIMOTO, J SAKURAI, T NAITO, Y |
| description | Determination of the standard elimination kinetics of tumor markers will be helpful in the diagnosis of malignancies. We analyzed the disappearance curves for serum tumor marker levels after resection of intrathoracic malignancies. Serum levels of CEA, SLX, AFP, CA 19-9, SCC, TPA and CYFRA were measured several times after surgery in a total of 40 patients. To obtain precise biological half-lives, we applied non-linear least square analysis, taking into consideration the possibility of residual tumor cells. Disappearance curves were monophasic for CEA, SCC, TPA, CYFRA and SLX and biphasic for CA 19-9 and AFP. Temporary elevation of serum levels after surgery was observed for SCC, TPA and CYFRA. The average half-lives of CEA, SLX, SCC, TPA and CYFRA were 1.5 days, 2.7 days, 2.2 hours, 2.5 hours and 1.5 hours, respectively. The average half-life of CA 19-9 was 0.5 days in the first compartment and 4.3 days in the second compartment, while that of AFP was 1.0 days and 6.3 days, respectively. These values will be helpful in the interpretation of serum tumor marker levels after surgery. |
| doi_str_mv | 10.1177/172460089901400207 |
| format | Article |
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We analyzed the disappearance curves for serum tumor marker levels after resection of intrathoracic malignancies. Serum levels of CEA, SLX, AFP, CA 19-9, SCC, TPA and CYFRA were measured several times after surgery in a total of 40 patients. To obtain precise biological half-lives, we applied non-linear least square analysis, taking into consideration the possibility of residual tumor cells. Disappearance curves were monophasic for CEA, SCC, TPA, CYFRA and SLX and biphasic for CA 19-9 and AFP. Temporary elevation of serum levels after surgery was observed for SCC, TPA and CYFRA. The average half-lives of CEA, SLX, SCC, TPA and CYFRA were 1.5 days, 2.7 days, 2.2 hours, 2.5 hours and 1.5 hours, respectively. The average half-life of CA 19-9 was 0.5 days in the first compartment and 4.3 days in the second compartment, while that of AFP was 1.0 days and 6.3 days, respectively. 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MAEBEYA, S ; SUZUMA, T ; BESSHO, T ; TANINO, H ; ARIMOTO, J ; SAKURAI, T ; NAITO, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-60dbe60b1e041a320307ec001416e0f85f16bba29e61235816f7b4923bc48fc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, Neoplasm - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>CA-19-9 Antigen - blood</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Keratin-19</topic><topic>Keratins</topic><topic>Lewis Blood-Group System</topic><topic>Lewis X Antigen - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oligosaccharides - blood</topic><topic>Pneumology</topic><topic>Serpins</topic><topic>Thoracic Neoplasms - mortality</topic><topic>Thoracic Neoplasms - surgery</topic><topic>Tissue Polypeptide Antigen - blood</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YOSHIMASU, T</creatorcontrib><creatorcontrib>MAEBEYA, S</creatorcontrib><creatorcontrib>SUZUMA, T</creatorcontrib><creatorcontrib>BESSHO, T</creatorcontrib><creatorcontrib>TANINO, H</creatorcontrib><creatorcontrib>ARIMOTO, J</creatorcontrib><creatorcontrib>SAKURAI, T</creatorcontrib><creatorcontrib>NAITO, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The International journal of biological markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIMASU, T</au><au>MAEBEYA, S</au><au>SUZUMA, T</au><au>BESSHO, T</au><au>TANINO, H</au><au>ARIMOTO, J</au><au>SAKURAI, T</au><au>NAITO, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disappearance curves for tumor markers after resection of intrathoracic malignancies</atitle><jtitle>The International journal of biological markers</jtitle><addtitle>Int J Biol Markers</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>14</volume><issue>2</issue><spage>99</spage><epage>105</epage><pages>99-105</pages><issn>0393-6155</issn><eissn>1724-6008</eissn><abstract>Determination of the standard elimination kinetics of tumor markers will be helpful in the diagnosis of malignancies. 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| subjects | Adult Aged Aged, 80 and over Antigens, Neoplasm - blood Biological and medical sciences Biomarkers, Tumor - blood CA-19-9 Antigen - blood Carcinoembryonic Antigen - blood Female Humans Keratin-19 Keratins Lewis Blood-Group System Lewis X Antigen - blood Male Medical sciences Middle Aged Oligosaccharides - blood Pneumology Serpins Thoracic Neoplasms - mortality Thoracic Neoplasms - surgery Tissue Polypeptide Antigen - blood Tumors of the respiratory system and mediastinum |
| title | Disappearance curves for tumor markers after resection of intrathoracic malignancies |
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