Hepatic Perfusion Changes in Patients with Cirrhosis: Indices of Hepatic Arterial Blood Flow
PURPOSE:This study used radionuclide angiography to evaluate semiquantitatively the hepatic arterial blood flow changes associated with cirrhosis. METHODS:The parameters of net arterial hepatic perfusion were estimated by analysis of first-pass flow studies in 11 control participants and in 15 patie...
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| Veröffentlicht in: | Clinical nuclear medicine 1999-07, Vol.24 (7), p.507-510 |
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| container_title | Clinical nuclear medicine |
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| creator | KORANDA, PAVEL MYSLIVEČEK, MIROSLAV ERBAN, JIŘI SEIDLOVÁ, VLASTA HUÁK, VÁCLAV |
| description | PURPOSE:This study used radionuclide angiography to evaluate semiquantitatively the hepatic arterial blood flow changes associated with cirrhosis.
METHODS:The parameters of net arterial hepatic perfusion were estimated by analysis of first-pass flow studies in 11 control participants and in 15 patients with cirrhosis (Child-Pugh classification B-C). Hepatic, renal, and splenic time-activity curves were generated, normalized per pixel, and corrected for background. The rate of hepatic arterial blood flow was compared with the reference kidney and spleen perfusion using the hepatorenal and hepatolienal perfusion indices, respectively. These indices were defined as
RESULTS:The values of both these perfusion indices are significantly greater in the patients with cirrhosis than in controls (hepatorenal perfusion index, P < 0.01; hepatolienal perfusion index, P < 0.05). The values of the hepatic perfusion index (the ratio of the arterial to the total liver blood flow), which were also calculated, were elevated in the patients with cirrhosis (P < 0.01).
CONCLUSIONS:The results confirm that the net hepatic arterial blood flow is increased in patients with cirrhosis. Radionuclide angiography accompanied by calculation of arterial perfusion indices may provide semiquantitative parameters of net hepatic arterial blood flow. |
| doi_str_mv | 10.1097/00003072-199907000-00007 |
| format | Article |
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METHODS:The parameters of net arterial hepatic perfusion were estimated by analysis of first-pass flow studies in 11 control participants and in 15 patients with cirrhosis (Child-Pugh classification B-C). Hepatic, renal, and splenic time-activity curves were generated, normalized per pixel, and corrected for background. The rate of hepatic arterial blood flow was compared with the reference kidney and spleen perfusion using the hepatorenal and hepatolienal perfusion indices, respectively. These indices were defined as
RESULTS:The values of both these perfusion indices are significantly greater in the patients with cirrhosis than in controls (hepatorenal perfusion index, P < 0.01; hepatolienal perfusion index, P < 0.05). The values of the hepatic perfusion index (the ratio of the arterial to the total liver blood flow), which were also calculated, were elevated in the patients with cirrhosis (P < 0.01).
CONCLUSIONS:The results confirm that the net hepatic arterial blood flow is increased in patients with cirrhosis. Radionuclide angiography accompanied by calculation of arterial perfusion indices may provide semiquantitative parameters of net hepatic arterial blood flow.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-199907000-00007</identifier><identifier>PMID: 10402004</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Biological and medical sciences ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatic Artery - diagnostic imaging ; Humans ; Kidney - diagnostic imaging ; Liver - blood supply ; Liver - diagnostic imaging ; Liver Circulation ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - physiopathology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. Semiology ; Radionuclide Angiography - methods ; Spleen - blood supply ; Spleen - diagnostic imaging</subject><ispartof>Clinical nuclear medicine, 1999-07, Vol.24 (7), p.507-510</ispartof><rights>1999 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2627-b78608d265a503629db1b286beeb063e317cf977d987d06ec6f994135ee1793d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1857340$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10402004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KORANDA, PAVEL</creatorcontrib><creatorcontrib>MYSLIVEČEK, MIROSLAV</creatorcontrib><creatorcontrib>ERBAN, JIŘI</creatorcontrib><creatorcontrib>SEIDLOVÁ, VLASTA</creatorcontrib><creatorcontrib>HUÁK, VÁCLAV</creatorcontrib><title>Hepatic Perfusion Changes in Patients with Cirrhosis: Indices of Hepatic Arterial Blood Flow</title><title>Clinical nuclear medicine</title><addtitle>Clin Nucl Med</addtitle><description>PURPOSE:This study used radionuclide angiography to evaluate semiquantitatively the hepatic arterial blood flow changes associated with cirrhosis.
METHODS:The parameters of net arterial hepatic perfusion were estimated by analysis of first-pass flow studies in 11 control participants and in 15 patients with cirrhosis (Child-Pugh classification B-C). Hepatic, renal, and splenic time-activity curves were generated, normalized per pixel, and corrected for background. The rate of hepatic arterial blood flow was compared with the reference kidney and spleen perfusion using the hepatorenal and hepatolienal perfusion indices, respectively. These indices were defined as
RESULTS:The values of both these perfusion indices are significantly greater in the patients with cirrhosis than in controls (hepatorenal perfusion index, P < 0.01; hepatolienal perfusion index, P < 0.05). The values of the hepatic perfusion index (the ratio of the arterial to the total liver blood flow), which were also calculated, were elevated in the patients with cirrhosis (P < 0.01).
CONCLUSIONS:The results confirm that the net hepatic arterial blood flow is increased in patients with cirrhosis. Radionuclide angiography accompanied by calculation of arterial perfusion indices may provide semiquantitative parameters of net hepatic arterial blood flow.</description><subject>Biological and medical sciences</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatic Artery - diagnostic imaging</subject><subject>Humans</subject><subject>Kidney - diagnostic imaging</subject><subject>Liver - blood supply</subject><subject>Liver - diagnostic imaging</subject><subject>Liver Circulation</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Radionuclide Angiography - methods</subject><subject>Spleen - blood supply</subject><subject>Spleen - diagnostic imaging</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtv1DAQgC0EokvhLyAfELfA2E784FZWlFaqRA9wQ7IcZ0IM3nixE63673HZLXDBF8sz3zz0mRDK4A0Do95CPQIUb5gxBlR9Nfch9YhsWCdkA5ybx2QDQorGKMnPyLNSvgMwyWT7lJwxaIEDtBvy9Qr3bgme3mIe1xLSTLeTm79hoWGmtzWF81LoISwT3Yacp1RCeUev5yH4yqSRPjS4yAvm4CJ9H1Ma6GVMh-fkyehiwRen-5x8ufzweXvV3Hz6eL29uGk8l1w1vdIS9MBl57q6MjdDz3quZY_YgxQomPKjUWowWg0g0cvRmJaJDpEpIwZxTl4f--5z-rliWewuFI8xuhnTWqw0WnOu2wrqI-hzKiXjaPc57Fy-swzsvVn7YNb-Mfs7pGrpy9OMtd_h8E_hUWUFXp0AV7yLY3azD-UvpzslWqhYe8QOKVZh5UdcD5jthC4uk_3fx4pfjx6Ozw</recordid><startdate>199907</startdate><enddate>199907</enddate><creator>KORANDA, PAVEL</creator><creator>MYSLIVEČEK, MIROSLAV</creator><creator>ERBAN, JIŘI</creator><creator>SEIDLOVÁ, VLASTA</creator><creator>HUÁK, VÁCLAV</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199907</creationdate><title>Hepatic Perfusion Changes in Patients with Cirrhosis: Indices of Hepatic Arterial Blood Flow</title><author>KORANDA, PAVEL ; MYSLIVEČEK, MIROSLAV ; ERBAN, JIŘI ; SEIDLOVÁ, VLASTA ; HUÁK, VÁCLAV</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2627-b78608d265a503629db1b286beeb063e317cf977d987d06ec6f994135ee1793d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatic Artery - diagnostic imaging</topic><topic>Humans</topic><topic>Kidney - diagnostic imaging</topic><topic>Liver - blood supply</topic><topic>Liver - diagnostic imaging</topic><topic>Liver Circulation</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Radionuclide Angiography - methods</topic><topic>Spleen - blood supply</topic><topic>Spleen - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KORANDA, PAVEL</creatorcontrib><creatorcontrib>MYSLIVEČEK, MIROSLAV</creatorcontrib><creatorcontrib>ERBAN, JIŘI</creatorcontrib><creatorcontrib>SEIDLOVÁ, VLASTA</creatorcontrib><creatorcontrib>HUÁK, VÁCLAV</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KORANDA, PAVEL</au><au>MYSLIVEČEK, MIROSLAV</au><au>ERBAN, JIŘI</au><au>SEIDLOVÁ, VLASTA</au><au>HUÁK, VÁCLAV</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatic Perfusion Changes in Patients with Cirrhosis: Indices of Hepatic Arterial Blood Flow</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>1999-07</date><risdate>1999</risdate><volume>24</volume><issue>7</issue><spage>507</spage><epage>510</epage><pages>507-510</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>PURPOSE:This study used radionuclide angiography to evaluate semiquantitatively the hepatic arterial blood flow changes associated with cirrhosis.
METHODS:The parameters of net arterial hepatic perfusion were estimated by analysis of first-pass flow studies in 11 control participants and in 15 patients with cirrhosis (Child-Pugh classification B-C). Hepatic, renal, and splenic time-activity curves were generated, normalized per pixel, and corrected for background. The rate of hepatic arterial blood flow was compared with the reference kidney and spleen perfusion using the hepatorenal and hepatolienal perfusion indices, respectively. These indices were defined as
RESULTS:The values of both these perfusion indices are significantly greater in the patients with cirrhosis than in controls (hepatorenal perfusion index, P < 0.01; hepatolienal perfusion index, P < 0.05). The values of the hepatic perfusion index (the ratio of the arterial to the total liver blood flow), which were also calculated, were elevated in the patients with cirrhosis (P < 0.01).
CONCLUSIONS:The results confirm that the net hepatic arterial blood flow is increased in patients with cirrhosis. Radionuclide angiography accompanied by calculation of arterial perfusion indices may provide semiquantitative parameters of net hepatic arterial blood flow.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10402004</pmid><doi>10.1097/00003072-199907000-00007</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Hepatic Artery - diagnostic imaging Humans Kidney - diagnostic imaging Liver - blood supply Liver - diagnostic imaging Liver Circulation Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - physiopathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Radionuclide Angiography - methods Spleen - blood supply Spleen - diagnostic imaging |
| title | Hepatic Perfusion Changes in Patients with Cirrhosis: Indices of Hepatic Arterial Blood Flow |
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