Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that regulate a wide variety of physiological responses and pathological processes. They are produced by various cell types through distinct enzymatic pathways and act on target cells via specific G-protein-coupl...
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| Veröffentlicht in: | Trends in molecular medicine 2008-10, Vol.14 (10), p.461-469 |
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| creator | Harizi, Hedi Corcuff, Jean-Benoît Gualde, Norbert |
| description | Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that regulate a wide variety of physiological responses and pathological processes. They are produced by various cell types through distinct enzymatic pathways and act on target cells via specific G-protein-coupled receptors. Although originally recognized for their capacity to elicit biological responses such as vascular homeostasis, protection of the gastric mucosa and platelet aggregation, eicosanoids are now understood to regulate immunopathological processes ranging from inflammatory responses to chronic tissue remodelling, cancer, asthma, rheumatoid arthritis and autoimmune disorders. Here, we review the major properties of eicosanoids and their expanding roles in biology and medicine. |
| doi_str_mv | 10.1016/j.molmed.2008.08.005 |
| format | Article |
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| subjects | Arachidonic Acid - metabolism Eicosanoids - metabolism Eicosanoids - physiology Immunity - physiology Inflammation - metabolism Inflammation - physiopathology Models, Biological Pathology Receptors, Eicosanoid - metabolism Receptors, Eicosanoid - physiology |
| title | Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology |
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