Synergistic effect of formulated plasmid and needle-free injection for genetic vaccines

A plasmid-based gene expression system was complexed with protective, interactive, and non-condensing (PINC) polymer system and administered with Medi-Jector, a needle-free injection device (NFID), to achieve high and sustained levels of antigen-specific antibodies in blood circulation. Human growth...

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Veröffentlicht in:	Pharmaceutical research 1999-06, Vol.16 (6), p.889-895
Hauptverfasser:	ANWER, K, EARLE, K. A, ROLLAND, A. P, MEI SHI, JIJUN WANG, MUMPER, R. J, PROCTOR, B, JANSA, K, LEDEBUR, H. C, DAVIS, S, EAGLSTEIN, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens beta-Galactosidase - biosynthesis Biological and medical sciences Cytomegalovirus Dogs Efficiency Female Gene expression General pharmacology Genetic Vectors - administration & dosage Growth hormones Human Growth Hormone - administration & dosage Human Growth Hormone - genetics Human Growth Hormone - immunology Humans Immunoglobulin G - immunology Immunomodulators Injections, Jet Laboratory animals Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasmids Plasmids - genetics Polymers Polymers - administration & dosage Povidone - administration & dosage Povidone - chemistry Swine Vaccination - methods Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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