Mouse semaphorin H inhibits neurite outgrowth from sensory neurons
Mouse semaphorin H (M-semaH) was structurally similar to semaphorin III/D, a mammalian homologue of collapsin 1 which was identified as a collapsing factor for sensory nerves. In this study we investigated the expression patterns of M-semaH mRNA and the protein binding sites in the trunk of mouse em...
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| Veröffentlicht in: | Neuroscience research 1999-04, Vol.33 (4), p.269-274 |
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| container_title | Neuroscience research |
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| creator | Miyazaki, Nobuo Furuyama, Tatsuo Amasaki, Mayumi Sugimoto, Hisako Sakai, Takayoshi Takeda, Noriaki Kubo, Takeshi Inagaki, Shinobu |
| description | Mouse semaphorin H (M-semaH) was structurally similar to semaphorin III/D, a mammalian homologue of collapsin 1 which was identified as a collapsing factor for sensory nerves. In this study we investigated the expression patterns of M-semaH mRNA and the protein binding sites in the trunk of mouse embryos. M-semaH mRNA was expressed in the mesenchymal tissues surrounding each dorsal root ganglia. These tissues include the caudal sclerotome and perinotochordal mesenchyme, which were thought to express factors repulsive to axons. M-semaH binding was detected on the spinal nerves. We further investigated, using in vitro co-culture assay, whether M-semaH acted as a chemorepulsive molecule on sensory axons. The results suggested that M-semaH was a candidate for a chemorepellent expressed in the mesenchyme surrounding the sensory ganglia, which is involved in the axonal guidance mechanism of sensory nerves in the trunk. |
| doi_str_mv | 10.1016/S0168-0102(99)00015-2 |
| format | Article |
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In this study we investigated the expression patterns of M-semaH mRNA and the protein binding sites in the trunk of mouse embryos. M-semaH mRNA was expressed in the mesenchymal tissues surrounding each dorsal root ganglia. These tissues include the caudal sclerotome and perinotochordal mesenchyme, which were thought to express factors repulsive to axons. M-semaH binding was detected on the spinal nerves. We further investigated, using in vitro co-culture assay, whether M-semaH acted as a chemorepulsive molecule on sensory axons. The results suggested that M-semaH was a candidate for a chemorepellent expressed in the mesenchyme surrounding the sensory ganglia, which is involved in the axonal guidance mechanism of sensory nerves in the trunk.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/S0168-0102(99)00015-2</identifier><identifier>PMID: 10401979</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>3T3 Cells ; Animals ; Axon ; Dorsal root ganglion ; Ganglia, Spinal - embryology ; Ganglia, Spinal - metabolism ; Glycoproteins - biosynthesis ; Glycoproteins - genetics ; Glycoproteins - physiology ; Membrane Proteins ; Mice ; Mouse ; Neurites - metabolism ; Neurons, Afferent - metabolism ; Outgrowth ; Repulsion ; RNA, Messenger - biosynthesis ; Semaphorin H ; Sensory nerve</subject><ispartof>Neuroscience research, 1999-04, Vol.33 (4), p.269-274</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-bdc3b7a6bd8c614ca70538a936d707d7dd2345e5885213abc0f7f47f053ab72b3</citedby><cites>FETCH-LOGICAL-c390t-bdc3b7a6bd8c614ca70538a936d707d7dd2345e5885213abc0f7f47f053ab72b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-0102(99)00015-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10401979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazaki, Nobuo</creatorcontrib><creatorcontrib>Furuyama, Tatsuo</creatorcontrib><creatorcontrib>Amasaki, Mayumi</creatorcontrib><creatorcontrib>Sugimoto, Hisako</creatorcontrib><creatorcontrib>Sakai, Takayoshi</creatorcontrib><creatorcontrib>Takeda, Noriaki</creatorcontrib><creatorcontrib>Kubo, Takeshi</creatorcontrib><creatorcontrib>Inagaki, Shinobu</creatorcontrib><title>Mouse semaphorin H inhibits neurite outgrowth from sensory neurons</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>Mouse semaphorin H (M-semaH) was structurally similar to semaphorin III/D, a mammalian homologue of collapsin 1 which was identified as a collapsing factor for sensory nerves. In this study we investigated the expression patterns of M-semaH mRNA and the protein binding sites in the trunk of mouse embryos. M-semaH mRNA was expressed in the mesenchymal tissues surrounding each dorsal root ganglia. These tissues include the caudal sclerotome and perinotochordal mesenchyme, which were thought to express factors repulsive to axons. M-semaH binding was detected on the spinal nerves. We further investigated, using in vitro co-culture assay, whether M-semaH acted as a chemorepulsive molecule on sensory axons. The results suggested that M-semaH was a candidate for a chemorepellent expressed in the mesenchyme surrounding the sensory ganglia, which is involved in the axonal guidance mechanism of sensory nerves in the trunk.</description><subject>3T3 Cells</subject><subject>Animals</subject><subject>Axon</subject><subject>Dorsal root ganglion</subject><subject>Ganglia, Spinal - embryology</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Glycoproteins - biosynthesis</subject><subject>Glycoproteins - genetics</subject><subject>Glycoproteins - physiology</subject><subject>Membrane Proteins</subject><subject>Mice</subject><subject>Mouse</subject><subject>Neurites - metabolism</subject><subject>Neurons, Afferent - metabolism</subject><subject>Outgrowth</subject><subject>Repulsion</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Semaphorin H</subject><subject>Sensory nerve</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqXwE0CZEAwBO05ie0JQ8SUVMQCz5dgXatTExU5A_fe4TYXYWO6Ge-5O74PQMcEXBJPy8iUWnmKCszMhzjHGpEizHTQmnGUpJ4TsovEvMkIHIXxEiIqc7qMRwTkmgokxunlyfYAkQKOWc-dtmzwktp3bynYhaaH3toPE9d27d9_dPKm9ayLcBudXm7FrwyHaq9UiwNG2T9Db3e3r9CGdPd8_Tq9nqaYCd2llNK2YKivDdUlyrRguKFeCloZhZpgxGc0LKDgvMkJVpXHN6pzVkVIVyyo6QafD3aV3nz2ETjY2aFgsVAsxhCwF54TyIoLFAGrvQvBQy6W3jfIrSbBcy5MbeXJtRgohN_JkFvdOtg_6qgHzZ2uwFYGrAYAY88uCl0FbaDUY60F30jj7z4sfKBF-8A</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Miyazaki, Nobuo</creator><creator>Furuyama, Tatsuo</creator><creator>Amasaki, Mayumi</creator><creator>Sugimoto, Hisako</creator><creator>Sakai, Takayoshi</creator><creator>Takeda, Noriaki</creator><creator>Kubo, Takeshi</creator><creator>Inagaki, Shinobu</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Mouse semaphorin H inhibits neurite outgrowth from sensory neurons</title><author>Miyazaki, Nobuo ; Furuyama, Tatsuo ; Amasaki, Mayumi ; Sugimoto, Hisako ; Sakai, Takayoshi ; Takeda, Noriaki ; Kubo, Takeshi ; Inagaki, Shinobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-bdc3b7a6bd8c614ca70538a936d707d7dd2345e5885213abc0f7f47f053ab72b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>3T3 Cells</topic><topic>Animals</topic><topic>Axon</topic><topic>Dorsal root ganglion</topic><topic>Ganglia, Spinal - embryology</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Glycoproteins - biosynthesis</topic><topic>Glycoproteins - genetics</topic><topic>Glycoproteins - physiology</topic><topic>Membrane Proteins</topic><topic>Mice</topic><topic>Mouse</topic><topic>Neurites - metabolism</topic><topic>Neurons, Afferent - metabolism</topic><topic>Outgrowth</topic><topic>Repulsion</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Semaphorin H</topic><topic>Sensory nerve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyazaki, Nobuo</creatorcontrib><creatorcontrib>Furuyama, Tatsuo</creatorcontrib><creatorcontrib>Amasaki, Mayumi</creatorcontrib><creatorcontrib>Sugimoto, Hisako</creatorcontrib><creatorcontrib>Sakai, Takayoshi</creatorcontrib><creatorcontrib>Takeda, Noriaki</creatorcontrib><creatorcontrib>Kubo, Takeshi</creatorcontrib><creatorcontrib>Inagaki, Shinobu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazaki, Nobuo</au><au>Furuyama, Tatsuo</au><au>Amasaki, Mayumi</au><au>Sugimoto, Hisako</au><au>Sakai, Takayoshi</au><au>Takeda, Noriaki</au><au>Kubo, Takeshi</au><au>Inagaki, Shinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse semaphorin H inhibits neurite outgrowth from sensory neurons</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>33</volume><issue>4</issue><spage>269</spage><epage>274</epage><pages>269-274</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>Mouse semaphorin H (M-semaH) was structurally similar to semaphorin III/D, a mammalian homologue of collapsin 1 which was identified as a collapsing factor for sensory nerves. 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| ispartof | Neuroscience research, 1999-04, Vol.33 (4), p.269-274 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | 3T3 Cells Animals Axon Dorsal root ganglion Ganglia, Spinal - embryology Ganglia, Spinal - metabolism Glycoproteins - biosynthesis Glycoproteins - genetics Glycoproteins - physiology Membrane Proteins Mice Mouse Neurites - metabolism Neurons, Afferent - metabolism Outgrowth Repulsion RNA, Messenger - biosynthesis Semaphorin H Sensory nerve |
| title | Mouse semaphorin H inhibits neurite outgrowth from sensory neurons |
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