Acute Effects of Vigabatrin on Brain GABA and Homocarnosine in Patients with Complex Partial Seizures

Purpose: The acute, subacute, and chronic effects of vigabatrin (VGB) were studied in patients with refractory complex partial seizures. VGB increases human brain γ‐aminobutyric acid (GABA) and the related metabolites, homocarnosine and 2‐pyrrolidinone. Methods: In vivo measurements of GABA and homo...

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Veröffentlicht in:	Epilepsia (Copenhagen) 1999-07, Vol.40 (7), p.958-964
Hauptverfasser:	Petroff, Ognen A. C., Hyder, Fahmeed, Collins, Theresa, Mattson, Richard H., Rothman, Douglas L.
Format:	Artikel
Sprache:	eng
Schlagworte:	1H nuclear magnetic resonance spectroscopy Administration, Oral Adult Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - drug effects Brain - metabolism Brain Chemistry - drug effects Carnosine - analogs & derivatives Carnosine - analysis Carnosine - metabolism Dose-Response Relationship, Drug Drug Administration Schedule Epilepsy, Complex Partial - drug therapy Epilepsy, Complex Partial - metabolism Female gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - analysis gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacokinetics gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Homocarnosine Human epilepsy Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Neuropharmacology Occipital Lobe - chemistry Occipital Lobe - drug effects Occipital Lobe - metabolism Pharmacology. Drug treatments Vigabatrin γ‐Aminobutyric acid
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