Evolving concepts of thyroid hormone action

Evolving concepts of thyroid hormone action

The past 25 years have witnessed dramatic changes in our concepts of thyroid hormone action. Progress in this area was made possible by the recognition of the central role of triiodothyronine in mediating thyroid hormone action and the recognition of specific nuclear receptors in target tissues as d...

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Veröffentlicht in:Biochimie 1999-05, Vol.81 (5), p.539-543
1. Verfasser: Oppenheimer, Jack H
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Brain - growth & development
Cell Nucleus - metabolism
Gene Expression Regulation
Humans
nuclear receptors
thyroid hormone action
Thyroid Hormones - metabolism
Thyroid Hormones - physiology
triiodothyronine
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container_title Biochimie
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creator Oppenheimer, Jack H
description The past 25 years have witnessed dramatic changes in our concepts of thyroid hormone action. Progress in this area was made possible by the recognition of the central role of triiodothyronine in mediating thyroid hormone action and the recognition of specific nuclear receptors in target tissues as demonstrated by displacement studies. The cloning of the receptors and receptor variants has enabled investigators to undertake detailed analyses of the biochemical events which underlie the physiological and pathological action of thyroid hormone.
doi_str_mv 10.1016/S0300-9084(99)80107-2
format Article
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Animals
Brain - growth & development
Cell Nucleus - metabolism
Gene Expression Regulation
Humans
nuclear receptors
thyroid hormone action
Thyroid Hormones - metabolism
Thyroid Hormones - physiology
triiodothyronine
title Evolving concepts of thyroid hormone action
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