Unique single-domain antigen binding fragments derived from naturally occurring camel heavy-chain antibodies

The humoral immune response of camels, dromedaries and llamas includes functional antibodies formed by two heavy chains and no light chains. The amino acid sequence of the variable domain of the naturally occurring heavy‐chain antibodies reveals the necessary adaptations to compensate for the absenc...

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Veröffentlicht in:	Journal of molecular recognition 1999-03, Vol.12 (2), p.131-140
Hauptverfasser:	Muyldermans, Serge, Lauwereys, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibody-antigen interactions antigen-binding loops Binding Sites, Antibody camel antibodies Camelus - immunology Camelus - metabolism Epitopes - immunology Genes, Immunoglobulin heavy-chain antibodies Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology immunoglobulins inhibitors Mice Models, Molecular Protein Conformation single-domain antibodies Species Specificity
Online-Zugang:	Volltext
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