Nuclear organization of pre-mRNA splicing factors

Nuclear organization of pre-mRNA splicing factors

The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucle...

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Veröffentlicht in:Current opinion in cell biology 1999-06, Vol.11 (3), p.372-377
Hauptverfasser: Sleeman, Judith E, Lamond, Angus I
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Nucleus - genetics
Cell Nucleus - metabolism
Humans
RNA Precursors - genetics
RNA Precursors - metabolism
RNA Splicing
RNA, Small Nuclear - metabolism
Spliceosomes - metabolism
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Zusammenfassung:The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(99)80052-0