Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer
Objective. This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly di...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 2008, Vol.42 (5), p.417-421 |
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| creator | Jancke, G. Damm, O. Rosell, J. Jahnson, S. |
| description | Objective. This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly diagnosed pTa/T1 bladder cancer between 1992 and 2001. The patients were followed prospectively in accordance with a control programme and possible risk factors for tumour recurrence were registered. Results. Local tumour recurrence was observed in 164 (35%) patients, another 117 (25%) patients had recurrence at other locations in the bladder (non-local recurrence) and 191 (40%) had no recurrence at all. Tumour size and multiple tumours were significantly associated with a higher risk for developing local recurrence as opposed to non-local recurrence. Tumour category was of borderline statistical significance. Gender and tumour grade were not found to be risk factors for developing local recurrence. Conclusion. Tumour size and multiplicity are risk factors for development of recurrence at the same location in the bladder as the primary tumour. Local tumour recurrence may be a result of non-radical primary transurethral resection. One may consider recommending standard re-resection within 6-8 weeks in patients with tumours >3 cm or those with multiple primary tumours. |
| doi_str_mv | 10.1080/00365590802016302 |
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This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly diagnosed pTa/T1 bladder cancer between 1992 and 2001. The patients were followed prospectively in accordance with a control programme and possible risk factors for tumour recurrence were registered. Results. Local tumour recurrence was observed in 164 (35%) patients, another 117 (25%) patients had recurrence at other locations in the bladder (non-local recurrence) and 191 (40%) had no recurrence at all. Tumour size and multiple tumours were significantly associated with a higher risk for developing local recurrence as opposed to non-local recurrence. Tumour category was of borderline statistical significance. Gender and tumour grade were not found to be risk factors for developing local recurrence. Conclusion. Tumour size and multiplicity are risk factors for development of recurrence at the same location in the bladder as the primary tumour. Local tumour recurrence may be a result of non-radical primary transurethral resection. One may consider recommending standard re-resection within 6-8 weeks in patients with tumours >3 cm or those with multiple primary tumours.</description><identifier>ISSN: 0036-5599</identifier><identifier>ISSN: 1651-2065</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.1080/00365590802016302</identifier><identifier>PMID: 18609266</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; BCG Vaccine - therapeutic use ; Biological and medical sciences ; Biopsy ; Bladder cancer ; Carcinoma, Transitional Cell - drug therapy ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - surgery ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; Cystoscopy ; Female ; Follow-Up Studies ; Humans ; local recurrence ; Male ; Medical sciences ; MEDICIN ; MEDICINE ; Middle Aged ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Neoplasm Staging ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - surgery ; Nephrology. Urinary tract diseases ; Prognosis ; Prospective Studies ; Risk Factors ; Tumor Burden ; Tumors of the urinary system ; Urinary Bladder - pathology ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - pathology ; Urinary Bladder Neoplasms - surgery ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>Scandinavian journal of urology and nephrology, 2008, Vol.42 (5), p.417-421</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>2008 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-4d8186d4f25663fee76b2985045deb0adfc1c4b2141f72dc8d84d99286b143bc3</citedby><cites>FETCH-LOGICAL-c471t-4d8186d4f25663fee76b2985045deb0adfc1c4b2141f72dc8d84d99286b143bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365590802016302$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365590802016302$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>230,314,780,784,885,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20834278$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18609266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-43347$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jancke, G.</creatorcontrib><creatorcontrib>Damm, O.</creatorcontrib><creatorcontrib>Rosell, J.</creatorcontrib><creatorcontrib>Jahnson, S.</creatorcontrib><title>Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>Objective. This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly diagnosed pTa/T1 bladder cancer between 1992 and 2001. The patients were followed prospectively in accordance with a control programme and possible risk factors for tumour recurrence were registered. Results. Local tumour recurrence was observed in 164 (35%) patients, another 117 (25%) patients had recurrence at other locations in the bladder (non-local recurrence) and 191 (40%) had no recurrence at all. Tumour size and multiple tumours were significantly associated with a higher risk for developing local recurrence as opposed to non-local recurrence. Tumour category was of borderline statistical significance. Gender and tumour grade were not found to be risk factors for developing local recurrence. Conclusion. Tumour size and multiplicity are risk factors for development of recurrence at the same location in the bladder as the primary tumour. Local tumour recurrence may be a result of non-radical primary transurethral resection. One may consider recommending standard re-resection within 6-8 weeks in patients with tumours >3 cm or those with multiple primary tumours.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>BCG Vaccine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bladder cancer</subject><subject>Carcinoma, Transitional Cell - drug therapy</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Combined Modality Therapy</subject><subject>Cystoscopy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>local recurrence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Tumor Burden</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder - pathology</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>0036-5599</issn><issn>1651-2065</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1rFDEUxYModq3-Ab5IXuyTY_M1mQz6Ulo_CgVRVl9DJh9uanYy3syw9L83ZdeKFPp0A_d3DifnIvSSkreUKHJKCJdt29cnI1Rywh6hFZUtbRiR7WO0ut03FeiP0LNSrgkhTFL5FB1RJUnPpFyhr99i-YWDsXOGgkMGnLI1CYO3C4AfrcdxxJOZox_ngndx3uBpbU6nNcULxNHADR6Scc4Dtqbi8Bw9CSYV_-Iwj9H3jx_W55-bqy-fLs_PrhorOjo3wqmawonAWil58L6TA-tVS0Tr_ECMC5ZaMTAqaOiYs8op4fqeKTlQwQfLj9GbvW_Z-WkZ9ARxW9PobKK-iD_OdIafOsVFC85FV_GTPT5B_r34MuttLNanZEafl6JlrzrVSVZBugct5FLAhztnSvRt7fpe7VXz6mC-DFvv_ikOPVfg9QEwpdYboFYVyx3HiOKCdapy7_dcHOsttmaXITk9m5uU4a-IP5Tj3X_yjTdp3lgDXl_nBcZ6jwd-8QfCP67u</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Jancke, G.</creator><creator>Damm, O.</creator><creator>Rosell, J.</creator><creator>Jahnson, S.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope></search><sort><creationdate>2008</creationdate><title>Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer</title><author>Jancke, G. ; Damm, O. ; Rosell, J. ; Jahnson, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-4d8186d4f25663fee76b2985045deb0adfc1c4b2141f72dc8d84d99286b143bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>BCG Vaccine - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bladder cancer</topic><topic>Carcinoma, Transitional Cell - drug therapy</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Combined Modality Therapy</topic><topic>Cystoscopy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>local recurrence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - surgery</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Tumor Burden</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder - pathology</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>online_resources</toplevel><creatorcontrib>Jancke, G.</creatorcontrib><creatorcontrib>Damm, O.</creatorcontrib><creatorcontrib>Rosell, J.</creatorcontrib><creatorcontrib>Jahnson, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><jtitle>Scandinavian journal of urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jancke, G.</au><au>Damm, O.</au><au>Rosell, J.</au><au>Jahnson, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>2008</date><risdate>2008</risdate><volume>42</volume><issue>5</issue><spage>417</spage><epage>421</epage><pages>417-421</pages><issn>0036-5599</issn><issn>1651-2065</issn><eissn>1651-2065</eissn><coden>SJUNAS</coden><abstract>Objective. This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly diagnosed pTa/T1 bladder cancer between 1992 and 2001. The patients were followed prospectively in accordance with a control programme and possible risk factors for tumour recurrence were registered. Results. Local tumour recurrence was observed in 164 (35%) patients, another 117 (25%) patients had recurrence at other locations in the bladder (non-local recurrence) and 191 (40%) had no recurrence at all. Tumour size and multiple tumours were significantly associated with a higher risk for developing local recurrence as opposed to non-local recurrence. Tumour category was of borderline statistical significance. Gender and tumour grade were not found to be risk factors for developing local recurrence. Conclusion. Tumour size and multiplicity are risk factors for development of recurrence at the same location in the bladder as the primary tumour. Local tumour recurrence may be a result of non-radical primary transurethral resection. One may consider recommending standard re-resection within 6-8 weeks in patients with tumours >3 cm or those with multiple primary tumours.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>18609266</pmid><doi>10.1080/00365590802016302</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of urology and nephrology, 2008, Vol.42 (5), p.417-421 |
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| subjects | Adult Aged Aged, 80 and over BCG Vaccine - therapeutic use Biological and medical sciences Biopsy Bladder cancer Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - surgery Chemotherapy, Adjuvant Combined Modality Therapy Cystoscopy Female Follow-Up Studies Humans local recurrence Male Medical sciences MEDICIN MEDICINE Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - surgery Nephrology. Urinary tract diseases Prognosis Prospective Studies Risk Factors Tumor Burden Tumors of the urinary system Urinary Bladder - pathology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - surgery Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer |
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