Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours
The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR. CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infreque...
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| Veröffentlicht in: | Cancer letters 1999-05, Vol.139 (2), p.199-205 |
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| container_title | Cancer letters |
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| creator | CHEUNG, Y.-L KERR, A. C MCFADYEN, M. C. E MELVIN, W. T MURRAY, G. I |
| description | The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR. CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infrequently expressed. Expression of the Ah receptor and Arnt which are involved in the transcriptional activation of the CYP1 genes was also studied. The Ah receptor mRNA and Arnt mRNA were consistently expressed both in kidney tumours and normal kidney. These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation. |
| doi_str_mv | 10.1016/S0304-3835(99)00045-2 |
| format | Article |
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These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(99)00045-2</identifier><identifier>PMID: 10395179</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Actins - biosynthesis ; Adenocarcinoma, Clear Cell - enzymology ; Adenocarcinoma, Clear Cell - metabolism ; Adenocarcinoma, Clear Cell - pathology ; Adult ; Aged ; Aged, 80 and over ; Aryl Hydrocarbon Hydroxylases ; Aryl Hydrocarbon Receptor Nuclear Translocator ; Biological and medical sciences ; Cytochrome P-450 CYP1A1 - biosynthesis ; Cytochrome P-450 CYP1A2 - biosynthesis ; Cytochrome P-450 CYP1B1 ; Cytochrome P-450 Enzyme System - biosynthesis ; DNA-Binding Proteins ; Female ; Humans ; Isoenzymes - biosynthesis ; Kidney - enzymology ; Kidney Neoplasms - enzymology ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Receptors, Aryl Hydrocarbon - biosynthesis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism ; Transcription Factors - biosynthesis ; Tumors of the urinary system</subject><ispartof>Cancer letters, 1999-05, Vol.139 (2), p.199-205</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-917c866477d9467f0a5a266b7b033d770223da29c447f7aca75b3189c266a7623</citedby><cites>FETCH-LOGICAL-c334t-917c866477d9467f0a5a266b7b033d770223da29c447f7aca75b3189c266a7623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1804610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10395179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEUNG, Y.-L</creatorcontrib><creatorcontrib>KERR, A. C</creatorcontrib><creatorcontrib>MCFADYEN, M. C. E</creatorcontrib><creatorcontrib>MELVIN, W. T</creatorcontrib><creatorcontrib>MURRAY, G. I</creatorcontrib><title>Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR. CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infrequently expressed. Expression of the Ah receptor and Arnt which are involved in the transcriptional activation of the CYP1 genes was also studied. The Ah receptor mRNA and Arnt mRNA were consistently expressed both in kidney tumours and normal kidney. These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation.</description><subject>Actins - biosynthesis</subject><subject>Adenocarcinoma, Clear Cell - enzymology</subject><subject>Adenocarcinoma, Clear Cell - metabolism</subject><subject>Adenocarcinoma, Clear Cell - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aryl Hydrocarbon Hydroxylases</subject><subject>Aryl Hydrocarbon Receptor Nuclear Translocator</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 CYP1A1 - biosynthesis</subject><subject>Cytochrome P-450 CYP1A2 - biosynthesis</subject><subject>Cytochrome P-450 CYP1B1</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>DNA-Binding Proteins</subject><subject>Female</subject><subject>Humans</subject><subject>Isoenzymes - biosynthesis</subject><subject>Kidney - enzymology</subject><subject>Kidney Neoplasms - enzymology</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Receptors, Aryl Hydrocarbon - biosynthesis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription Factors - biosynthesis</subject><subject>Tumors of the urinary system</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0FtLwzAYxvEgipuHj6D0QkTBatIc3uRyztNgoKBeeBXSNMVqDzNpwX17u3WoV8_NL3nhj9ARwZcEE3H1jClmMZWUnyl1jjFmPE620JhISGJQEm-j8S8Zob0QPnrEGfBdNCKYKk5AjdHspshz513dFqaM3PfCuxCKpo6aPJq-PZEJuRg2GfaaREUdvXeVqaPPIqvdMmq7qul8OEA7uSmDO9zsPnq9u32ZPsTzx_vZdDKPLaWsjRUBK4VgAJliAnJsuEmESCHFlGYAOEloZhJlGYMcjDXAU0qksj0yIBK6j06Hfxe--epcaHVVBOvK0tSu6YIWSoKQIHvIB2h9E4J3uV74ojJ-qQnWq4Z63VCvAmml9LqhXh043hzo0spl_14N0XpwsgEmWFPm3tS2CH9OYiZ6_AP113V9</recordid><startdate>19990524</startdate><enddate>19990524</enddate><creator>CHEUNG, Y.-L</creator><creator>KERR, A. C</creator><creator>MCFADYEN, M. C. E</creator><creator>MELVIN, W. T</creator><creator>MURRAY, G. I</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990524</creationdate><title>Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours</title><author>CHEUNG, Y.-L ; KERR, A. C ; MCFADYEN, M. C. E ; MELVIN, W. T ; MURRAY, G. I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-917c866477d9467f0a5a266b7b033d770223da29c447f7aca75b3189c266a7623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Actins - biosynthesis</topic><topic>Adenocarcinoma, Clear Cell - enzymology</topic><topic>Adenocarcinoma, Clear Cell - metabolism</topic><topic>Adenocarcinoma, Clear Cell - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aryl Hydrocarbon Hydroxylases</topic><topic>Aryl Hydrocarbon Receptor Nuclear Translocator</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 CYP1A1 - biosynthesis</topic><topic>Cytochrome P-450 CYP1A2 - biosynthesis</topic><topic>Cytochrome P-450 CYP1B1</topic><topic>Cytochrome P-450 Enzyme System - biosynthesis</topic><topic>DNA-Binding Proteins</topic><topic>Female</topic><topic>Humans</topic><topic>Isoenzymes - biosynthesis</topic><topic>Kidney - enzymology</topic><topic>Kidney Neoplasms - enzymology</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Receptors, Aryl Hydrocarbon - biosynthesis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription Factors - biosynthesis</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHEUNG, Y.-L</creatorcontrib><creatorcontrib>KERR, A. C</creatorcontrib><creatorcontrib>MCFADYEN, M. C. E</creatorcontrib><creatorcontrib>MELVIN, W. T</creatorcontrib><creatorcontrib>MURRAY, G. I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHEUNG, Y.-L</au><au>KERR, A. C</au><au>MCFADYEN, M. C. E</au><au>MELVIN, W. T</au><au>MURRAY, G. I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1999-05-24</date><risdate>1999</risdate><volume>139</volume><issue>2</issue><spage>199</spage><epage>205</epage><pages>199-205</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The presence of mRNA of individual members of the CYP1 gene family in normal and neoplastic kidney has been investigated by RTPCR. CYP1B1 mRNA was consistently expressed in both normal and neoplastic kidney while CYP1A1 was present in the majority of normal and neoplastic whereas CYP1A2 was infrequently expressed. Expression of the Ah receptor and Arnt which are involved in the transcriptional activation of the CYP1 genes was also studied. The Ah receptor mRNA and Arnt mRNA were consistently expressed both in kidney tumours and normal kidney. These results indicate differential expression of individual members of the CYP1 gene family in normal and neoplastic kidney and suggest that several mechanisms including the Ah receptor complex could be involved in their regulation.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>10395179</pmid><doi>10.1016/S0304-3835(99)00045-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer letters, 1999-05, Vol.139 (2), p.199-205 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Actins - biosynthesis Adenocarcinoma, Clear Cell - enzymology Adenocarcinoma, Clear Cell - metabolism Adenocarcinoma, Clear Cell - pathology Adult Aged Aged, 80 and over Aryl Hydrocarbon Hydroxylases Aryl Hydrocarbon Receptor Nuclear Translocator Biological and medical sciences Cytochrome P-450 CYP1A1 - biosynthesis Cytochrome P-450 CYP1A2 - biosynthesis Cytochrome P-450 CYP1B1 Cytochrome P-450 Enzyme System - biosynthesis DNA-Binding Proteins Female Humans Isoenzymes - biosynthesis Kidney - enzymology Kidney Neoplasms - enzymology Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Receptors, Aryl Hydrocarbon - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transcription Factors - biosynthesis Tumors of the urinary system |
| title | Differential expression of CYP1A1, CYP1A2, CYP1B1 in human kidney tumours |
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