Chimeric Axon Guidance Receptors: The Cytoplasmic Domains of Slit and Netrin Receptors Specify Attraction versus Repulsion

Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction; Roundabout (Robo) is a Slit receptor that mediates repulsion. Both ligands are expressed at the midline; both receptors have related structures and are often expressed by the same neurons. To determine if attracti...

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