The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice

Uncoupling protein 3 (UCP3) is suggested to protect mitochondria against aging and lipid-induced damage, possibly via modulation of reactive oxygen species (ROS) production. Here we show that mice overexpressing UCP3 (UCP3Tg) have a blunted age-induced increase in ROS production, assessed by electro...

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Veröffentlicht in:	FEBS letters 2008-12, Vol.582 (30), p.4147-4152
Hauptverfasser:	Nabben, Miranda, Hoeks, Joris, Briedé, Jacob J., Glatz, Jan F.C., Moonen-Kornips, Esther, Hesselink, Matthijs K.C., Schrauwen, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	4-HNE 4-hydroxynonenal 5,5-dimethyl-1-pyrolline N-oxide Age Factors Aging Aging - metabolism Aldehydes - pharmacology Animals bovine serum albumin BSA Cell Respiration DMPO electron spin resonance ESR FCCP Ion Channels - biosynthesis Lipid Peroxidation Mice mice overexpressing human skeletal muscle UCP3 Mild uncoupling Mitochondria Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Mitochondrial Proteins - biosynthesis Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - ultrastructure p-trifluoromethoxy carbonyl cyanide phenylhydrazone reactive oxygen species Reactive Oxygen Species - metabolism ROS SOD superoxide dismutase tibialis anterior UCP UCP3 UCP3Tg uncoupling protein Uncoupling Protein 3 wild type
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