Intravenous immune globulin in the therapy of peripartum cardiomyopathy
OBJECTIVES We sought to evaluate the effect of therapy with intravenous immune globulin on recovery of left ventricular function in women presenting with peripartum cardiomyopathy. BACKGROUND Peripartum cardiomyopathy is a rare complication of pregnancy that results in significant morbidity and mort...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1999-07, Vol.34 (1), p.177-180 |
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| creator | Bozkurt, Biykem Villaneuva, Flordeliza S Holubkov, Richard Tokarczyk, Tammy Alvarez, René J MacGowan, Guy A Murali, Srinivas Rosenblum, Warren D Feldman, Arthur M McNamara, Dennis M |
| description | OBJECTIVES
We sought to evaluate the effect of therapy with intravenous immune globulin on recovery of left ventricular function in women presenting with peripartum cardiomyopathy.
BACKGROUND
Peripartum cardiomyopathy is a rare complication of pregnancy that results in significant morbidity and mortality in women of childbearing age. Intravenous immune globulin has been reported to improve left ventricular systolic function in patients with acute dilated cardiomyopathy and myocarditis, but its effectiveness in peripartum cardiomyopathy is unknown.
METHODS
In this retrospective study, we compared the clinical outcomes of six women with peripartum cardiomyopathy treated with intravenous immune globulin (2 g/kg) with those of 11 recent historical control subjects. All women in the study were referred between 1991 and 1998 with class II to IV heart failure and a left ventricular ejection fraction of |
| doi_str_mv | 10.1016/S0735-1097(99)00161-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69875767</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735109799001618</els_id><sourcerecordid>69875767</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-e1953fecb3fde0057c65169f7e48548f2d886ef989527cdc20379d4564f652b53</originalsourceid><addsrcrecordid>eNqFkElLAzEUgIMoti4_QZmDiB5Gk5nJdhIpLoWCB_Uc0syLjcxmMlPovzddUG9CQnjhe9uH0BnBNwQTdvuKeU5TgiW_kvIaxy-Sij00JpSKNKeS76PxDzJCRyF8YoyZIPIQjQguYoDFGD1Nm97rJTTtEBJX10MDyUfVzofKNUk8_QLW1-tulbQ26cC7Tvt-qBOjfenaetV2ul-sTtCB1VWA0917jN4fH94mz-ns5Wk6uZ-lhmZ5nwKRNLdg5rktAWPKDaOEScuhELQQNiuFYGClkDTjpjQZzrksC8oKy2g2p_kxutzW7Xz7NUDoVe2CgarSDcQVFJOCU854BOkWNL4NwYNVnXe19itFsFobVBuDaq1HSak2BpWIeee7BsO8hvJP1lZZBC52gA5GV9brxrjwywnBsyKP2N0Wg2hj6cCrYBw0BkrnwfSqbN0_k3wD72KNPA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69875767</pqid></control><display><type>article</type><title>Intravenous immune globulin in the therapy of peripartum cardiomyopathy</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Bozkurt, Biykem ; Villaneuva, Flordeliza S ; Holubkov, Richard ; Tokarczyk, Tammy ; Alvarez, René J ; MacGowan, Guy A ; Murali, Srinivas ; Rosenblum, Warren D ; Feldman, Arthur M ; McNamara, Dennis M</creator><creatorcontrib>Bozkurt, Biykem ; Villaneuva, Flordeliza S ; Holubkov, Richard ; Tokarczyk, Tammy ; Alvarez, René J ; MacGowan, Guy A ; Murali, Srinivas ; Rosenblum, Warren D ; Feldman, Arthur M ; McNamara, Dennis M</creatorcontrib><description>OBJECTIVES
We sought to evaluate the effect of therapy with intravenous immune globulin on recovery of left ventricular function in women presenting with peripartum cardiomyopathy.
BACKGROUND
Peripartum cardiomyopathy is a rare complication of pregnancy that results in significant morbidity and mortality in women of childbearing age. Intravenous immune globulin has been reported to improve left ventricular systolic function in patients with acute dilated cardiomyopathy and myocarditis, but its effectiveness in peripartum cardiomyopathy is unknown.
METHODS
In this retrospective study, we compared the clinical outcomes of six women with peripartum cardiomyopathy treated with intravenous immune globulin (2 g/kg) with those of 11 recent historical control subjects. All women in the study were referred between 1991 and 1998 with class II to IV heart failure and a left ventricular ejection fraction of <0.40. Left ventricular ejection was reassessed during early follow-up (6.1 ± 2.9 months).
RESULTS
The two groups did not differ in terms of baseline left ventricular ejection fraction, left ventricular end-diastolic diameter, months to presentation, age or multiparity. The improvement in left ventricular ejection fraction in patients treated with immune globulin was significantly greater than in the conventionally treated group (increase of 26 ± 8 ejection fraction units vs. 13 ±13, p = 0.042).
CONCLUSIONS
In this small retrospective study of women with peripartum cardiomyopathy, patients treated with immune globulin had a greater improvement in ejection fraction during early follow-up than patients treated conventionally. Given the poor prognosis of women with peripartum cardiomyopathy who do not improve, this therapy merits further study.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(99)00161-8</identifier><identifier>PMID: 10400008</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathies - physiopathology ; Cardiomyopathies - therapy ; Female ; Heart ; Humans ; Immunoglobulins, Intravenous - therapeutic use ; Medical sciences ; Myocarditis. Cardiomyopathies ; Puerperal Disorders - physiopathology ; Puerperal Disorders - therapy ; Retrospective Studies ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left</subject><ispartof>Journal of the American College of Cardiology, 1999-07, Vol.34 (1), p.177-180</ispartof><rights>1999 American College of Cardiology</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-e1953fecb3fde0057c65169f7e48548f2d886ef989527cdc20379d4564f652b53</citedby><cites>FETCH-LOGICAL-c523t-e1953fecb3fde0057c65169f7e48548f2d886ef989527cdc20379d4564f652b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0735-1097(99)00161-8$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1887243$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10400008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bozkurt, Biykem</creatorcontrib><creatorcontrib>Villaneuva, Flordeliza S</creatorcontrib><creatorcontrib>Holubkov, Richard</creatorcontrib><creatorcontrib>Tokarczyk, Tammy</creatorcontrib><creatorcontrib>Alvarez, René J</creatorcontrib><creatorcontrib>MacGowan, Guy A</creatorcontrib><creatorcontrib>Murali, Srinivas</creatorcontrib><creatorcontrib>Rosenblum, Warren D</creatorcontrib><creatorcontrib>Feldman, Arthur M</creatorcontrib><creatorcontrib>McNamara, Dennis M</creatorcontrib><title>Intravenous immune globulin in the therapy of peripartum cardiomyopathy</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>OBJECTIVES
We sought to evaluate the effect of therapy with intravenous immune globulin on recovery of left ventricular function in women presenting with peripartum cardiomyopathy.
BACKGROUND
Peripartum cardiomyopathy is a rare complication of pregnancy that results in significant morbidity and mortality in women of childbearing age. Intravenous immune globulin has been reported to improve left ventricular systolic function in patients with acute dilated cardiomyopathy and myocarditis, but its effectiveness in peripartum cardiomyopathy is unknown.
METHODS
In this retrospective study, we compared the clinical outcomes of six women with peripartum cardiomyopathy treated with intravenous immune globulin (2 g/kg) with those of 11 recent historical control subjects. All women in the study were referred between 1991 and 1998 with class II to IV heart failure and a left ventricular ejection fraction of <0.40. Left ventricular ejection was reassessed during early follow-up (6.1 ± 2.9 months).
RESULTS
The two groups did not differ in terms of baseline left ventricular ejection fraction, left ventricular end-diastolic diameter, months to presentation, age or multiparity. The improvement in left ventricular ejection fraction in patients treated with immune globulin was significantly greater than in the conventionally treated group (increase of 26 ± 8 ejection fraction units vs. 13 ±13, p = 0.042).
CONCLUSIONS
In this small retrospective study of women with peripartum cardiomyopathy, patients treated with immune globulin had a greater improvement in ejection fraction during early follow-up than patients treated conventionally. Given the poor prognosis of women with peripartum cardiomyopathy who do not improve, this therapy merits further study.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - physiopathology</subject><subject>Cardiomyopathies - therapy</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Medical sciences</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Puerperal Disorders - physiopathology</subject><subject>Puerperal Disorders - therapy</subject><subject>Retrospective Studies</subject><subject>Stroke Volume</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLAzEUgIMoti4_QZmDiB5Gk5nJdhIpLoWCB_Uc0syLjcxmMlPovzddUG9CQnjhe9uH0BnBNwQTdvuKeU5TgiW_kvIaxy-Sij00JpSKNKeS76PxDzJCRyF8YoyZIPIQjQguYoDFGD1Nm97rJTTtEBJX10MDyUfVzofKNUk8_QLW1-tulbQ26cC7Tvt-qBOjfenaetV2ul-sTtCB1VWA0917jN4fH94mz-ns5Wk6uZ-lhmZ5nwKRNLdg5rktAWPKDaOEScuhELQQNiuFYGClkDTjpjQZzrksC8oKy2g2p_kxutzW7Xz7NUDoVe2CgarSDcQVFJOCU854BOkWNL4NwYNVnXe19itFsFobVBuDaq1HSak2BpWIeee7BsO8hvJP1lZZBC52gA5GV9brxrjwywnBsyKP2N0Wg2hj6cCrYBw0BkrnwfSqbN0_k3wD72KNPA</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Bozkurt, Biykem</creator><creator>Villaneuva, Flordeliza S</creator><creator>Holubkov, Richard</creator><creator>Tokarczyk, Tammy</creator><creator>Alvarez, René J</creator><creator>MacGowan, Guy A</creator><creator>Murali, Srinivas</creator><creator>Rosenblum, Warren D</creator><creator>Feldman, Arthur M</creator><creator>McNamara, Dennis M</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Intravenous immune globulin in the therapy of peripartum cardiomyopathy</title><author>Bozkurt, Biykem ; Villaneuva, Flordeliza S ; Holubkov, Richard ; Tokarczyk, Tammy ; Alvarez, René J ; MacGowan, Guy A ; Murali, Srinivas ; Rosenblum, Warren D ; Feldman, Arthur M ; McNamara, Dennis M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-e1953fecb3fde0057c65169f7e48548f2d886ef989527cdc20379d4564f652b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - physiopathology</topic><topic>Cardiomyopathies - therapy</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Medical sciences</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Puerperal Disorders - physiopathology</topic><topic>Puerperal Disorders - therapy</topic><topic>Retrospective Studies</topic><topic>Stroke Volume</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bozkurt, Biykem</creatorcontrib><creatorcontrib>Villaneuva, Flordeliza S</creatorcontrib><creatorcontrib>Holubkov, Richard</creatorcontrib><creatorcontrib>Tokarczyk, Tammy</creatorcontrib><creatorcontrib>Alvarez, René J</creatorcontrib><creatorcontrib>MacGowan, Guy A</creatorcontrib><creatorcontrib>Murali, Srinivas</creatorcontrib><creatorcontrib>Rosenblum, Warren D</creatorcontrib><creatorcontrib>Feldman, Arthur M</creatorcontrib><creatorcontrib>McNamara, Dennis M</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bozkurt, Biykem</au><au>Villaneuva, Flordeliza S</au><au>Holubkov, Richard</au><au>Tokarczyk, Tammy</au><au>Alvarez, René J</au><au>MacGowan, Guy A</au><au>Murali, Srinivas</au><au>Rosenblum, Warren D</au><au>Feldman, Arthur M</au><au>McNamara, Dennis M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravenous immune globulin in the therapy of peripartum cardiomyopathy</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>34</volume><issue>1</issue><spage>177</spage><epage>180</epage><pages>177-180</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>OBJECTIVES
We sought to evaluate the effect of therapy with intravenous immune globulin on recovery of left ventricular function in women presenting with peripartum cardiomyopathy.
BACKGROUND
Peripartum cardiomyopathy is a rare complication of pregnancy that results in significant morbidity and mortality in women of childbearing age. Intravenous immune globulin has been reported to improve left ventricular systolic function in patients with acute dilated cardiomyopathy and myocarditis, but its effectiveness in peripartum cardiomyopathy is unknown.
METHODS
In this retrospective study, we compared the clinical outcomes of six women with peripartum cardiomyopathy treated with intravenous immune globulin (2 g/kg) with those of 11 recent historical control subjects. All women in the study were referred between 1991 and 1998 with class II to IV heart failure and a left ventricular ejection fraction of <0.40. Left ventricular ejection was reassessed during early follow-up (6.1 ± 2.9 months).
RESULTS
The two groups did not differ in terms of baseline left ventricular ejection fraction, left ventricular end-diastolic diameter, months to presentation, age or multiparity. The improvement in left ventricular ejection fraction in patients treated with immune globulin was significantly greater than in the conventionally treated group (increase of 26 ± 8 ejection fraction units vs. 13 ±13, p = 0.042).
CONCLUSIONS
In this small retrospective study of women with peripartum cardiomyopathy, patients treated with immune globulin had a greater improvement in ejection fraction during early follow-up than patients treated conventionally. Given the poor prognosis of women with peripartum cardiomyopathy who do not improve, this therapy merits further study.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10400008</pmid><doi>10.1016/S0735-1097(99)00161-8</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Biological and medical sciences Cardiology. Vascular system Cardiomyopathies - physiopathology Cardiomyopathies - therapy Female Heart Humans Immunoglobulins, Intravenous - therapeutic use Medical sciences Myocarditis. Cardiomyopathies Puerperal Disorders - physiopathology Puerperal Disorders - therapy Retrospective Studies Stroke Volume Treatment Outcome Ventricular Function, Left |
| title | Intravenous immune globulin in the therapy of peripartum cardiomyopathy |
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