Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors
The activity of transcription factors like AP-1 and Oct-1 is critical for the regulation of gene expression. Whereas Oct-1 mainly regulates the expression of housekeeping genes, AP-1 is often involved in cellular responses to external stimuli and plays an essential role in the regulation of light-in...
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| Veröffentlicht in: | Vision research (Oxford) 1999-07, Vol.39 (15), p.2511-2518 |
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| creator | Hafezi, Farhad Marti, Andreas Grimm, Christian Wenzel, Andreas Remé, Charlotte E. |
| description | The activity of transcription factors like AP-1 and Oct-1 is critical for the regulation of gene expression. Whereas Oct-1 mainly regulates the expression of housekeeping genes, AP-1 is often involved in cellular responses to external stimuli and plays an essential role in the regulation of light-induced apoptosis of mouse retinal photoreceptors. In this study, we investigated AP-1 and Oct-1 DNA binding activity and AP-1 complex composition in the mouse retina during light-induced photoreceptor apoptosis. AP-1 DNA binding activity was low in dark-adapted animals but was transiently elevated within 12 h after exposure of mice to apoptosis-inducing levels of white fluorescent light. Maximal AP-1 activity was found 6 h after light-exposure. Antibody interference analysis at 6 h after damaging light exposure and under normal light conditions revealed that the major fraction of AP-1 consists of c-Fos/JunD heterodimers in both situations. In contrast to AP-1, Oct-1 DNA binding activity was maximal in dark-adapted animals and was reduced during photoreceptor apoptosis. Transient induction of AP-1 (c-Fos/JunD) and inactivation of Oct-1 may be crucial events for light-mediated apoptosis of retinal photoreceptors. |
| doi_str_mv | 10.1016/S0042-6989(98)00313-7 |
| format | Article |
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Whereas Oct-1 mainly regulates the expression of housekeeping genes, AP-1 is often involved in cellular responses to external stimuli and plays an essential role in the regulation of light-induced apoptosis of mouse retinal photoreceptors. In this study, we investigated AP-1 and Oct-1 DNA binding activity and AP-1 complex composition in the mouse retina during light-induced photoreceptor apoptosis. AP-1 DNA binding activity was low in dark-adapted animals but was transiently elevated within 12 h after exposure of mice to apoptosis-inducing levels of white fluorescent light. Maximal AP-1 activity was found 6 h after light-exposure. Antibody interference analysis at 6 h after damaging light exposure and under normal light conditions revealed that the major fraction of AP-1 consists of c-Fos/JunD heterodimers in both situations. In contrast to AP-1, Oct-1 DNA binding activity was maximal in dark-adapted animals and was reduced during photoreceptor apoptosis. Transient induction of AP-1 (c-Fos/JunD) and inactivation of Oct-1 may be crucial events for light-mediated apoptosis of retinal photoreceptors.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/S0042-6989(98)00313-7</identifier><identifier>PMID: 10396620</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; AP-1 ; Apoptosis ; Apoptosis - radiation effects ; Biological and medical sciences ; Dark Adaptation ; Development. Senescence. Regeneration. Transplantation ; DNA - metabolism ; DNA-Binding Proteins - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Host Cell Factor C1 ; Light ; Male ; Mice ; Mice, Inbred C57BL ; Mouse retina ; Oct-1 ; Octamer Transcription Factor-1 ; Photoreceptor Cells - cytology ; Photoreceptor Cells - radiation effects ; Retina - metabolism ; Time Factors ; Transcription factor ; Transcription Factor AP-1 - metabolism ; Transcription Factors - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 1999-07, Vol.39 (15), p.2511-2518</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-3cd35ebb2e8b6fc50b9c3aaf162c3da63f7789a93fe5ab985d217eb428fa52883</citedby><cites>FETCH-LOGICAL-c456t-3cd35ebb2e8b6fc50b9c3aaf162c3da63f7789a93fe5ab985d217eb428fa52883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0042-6989(98)00313-7$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1764726$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10396620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hafezi, Farhad</creatorcontrib><creatorcontrib>Marti, Andreas</creatorcontrib><creatorcontrib>Grimm, Christian</creatorcontrib><creatorcontrib>Wenzel, Andreas</creatorcontrib><creatorcontrib>Remé, Charlotte E.</creatorcontrib><title>Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>The activity of transcription factors like AP-1 and Oct-1 is critical for the regulation of gene expression. Whereas Oct-1 mainly regulates the expression of housekeeping genes, AP-1 is often involved in cellular responses to external stimuli and plays an essential role in the regulation of light-induced apoptosis of mouse retinal photoreceptors. In this study, we investigated AP-1 and Oct-1 DNA binding activity and AP-1 complex composition in the mouse retina during light-induced photoreceptor apoptosis. AP-1 DNA binding activity was low in dark-adapted animals but was transiently elevated within 12 h after exposure of mice to apoptosis-inducing levels of white fluorescent light. Maximal AP-1 activity was found 6 h after light-exposure. Antibody interference analysis at 6 h after damaging light exposure and under normal light conditions revealed that the major fraction of AP-1 consists of c-Fos/JunD heterodimers in both situations. In contrast to AP-1, Oct-1 DNA binding activity was maximal in dark-adapted animals and was reduced during photoreceptor apoptosis. Transient induction of AP-1 (c-Fos/JunD) and inactivation of Oct-1 may be crucial events for light-mediated apoptosis of retinal photoreceptors.</description><subject>Animals</subject><subject>AP-1</subject><subject>Apoptosis</subject><subject>Apoptosis - radiation effects</subject><subject>Biological and medical sciences</subject><subject>Dark Adaptation</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>DNA - metabolism</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Host Cell Factor C1</subject><subject>Light</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mouse retina</subject><subject>Oct-1</subject><subject>Octamer Transcription Factor-1</subject><subject>Photoreceptor Cells - cytology</subject><subject>Photoreceptor Cells - radiation effects</subject><subject>Retina - metabolism</subject><subject>Time Factors</subject><subject>Transcription factor</subject><subject>Transcription Factor AP-1 - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vFSEYRomxsdfqT9CwMEYXozAMXytz06pt0lgTdU0Y5qUXM3eYAtPEnT-93I-oO1ewOOeBHIReUPKOEirefyOkaxuhlX6j1VtCGGWNfIRWVEnVcNGJx2j1BzlFT3P-SQiRvNVP0CklTAvRkhX6fRG8hwRTCXbEF1_WuA_TEKZbbF0J96EEyDh6XDaAS7JTdinMJcQJ-wrElPH6a0OxnQZ840q9DUva2WO43ZSmTi0OBmznOJeYw35q3sQqgoN55z9DJ96OGZ4fzzP049PH7-eXzfXN56vz9XXjOi5Kw9zAOPR9C6oX3nHSa8es9VS0jg1WMC-l0lYzD9z2WvGhpRL6rlXe8lYpdoZeH3bnFO8WyMVsQ3YwjnaCuGRTM8mOdqyC_AC6FHNO4M2cwtamX4YSs0tv9ul3gjZamX16I6v38vjA0m9h-Mc6tK7AqyNgs7OjrzVdyH85KTrZiop9OGBQa9wHSCa7AFPNGGq0YoYY_vOTB7sGok8</recordid><startdate>19990701</startdate><enddate>19990701</enddate><creator>Hafezi, Farhad</creator><creator>Marti, Andreas</creator><creator>Grimm, Christian</creator><creator>Wenzel, Andreas</creator><creator>Remé, Charlotte E.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors</title><author>Hafezi, Farhad ; Marti, Andreas ; Grimm, Christian ; Wenzel, Andreas ; Remé, Charlotte E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-3cd35ebb2e8b6fc50b9c3aaf162c3da63f7789a93fe5ab985d217eb428fa52883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>AP-1</topic><topic>Apoptosis</topic><topic>Apoptosis - radiation effects</topic><topic>Biological and medical sciences</topic><topic>Dark Adaptation</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>DNA - metabolism</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Host Cell Factor C1</topic><topic>Light</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mouse retina</topic><topic>Oct-1</topic><topic>Octamer Transcription Factor-1</topic><topic>Photoreceptor Cells - cytology</topic><topic>Photoreceptor Cells - radiation effects</topic><topic>Retina - metabolism</topic><topic>Time Factors</topic><topic>Transcription factor</topic><topic>Transcription Factor AP-1 - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hafezi, Farhad</creatorcontrib><creatorcontrib>Marti, Andreas</creatorcontrib><creatorcontrib>Grimm, Christian</creatorcontrib><creatorcontrib>Wenzel, Andreas</creatorcontrib><creatorcontrib>Remé, Charlotte E.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hafezi, Farhad</au><au>Marti, Andreas</au><au>Grimm, Christian</au><au>Wenzel, Andreas</au><au>Remé, Charlotte E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>39</volume><issue>15</issue><spage>2511</spage><epage>2518</epage><pages>2511-2518</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>The activity of transcription factors like AP-1 and Oct-1 is critical for the regulation of gene expression. Whereas Oct-1 mainly regulates the expression of housekeeping genes, AP-1 is often involved in cellular responses to external stimuli and plays an essential role in the regulation of light-induced apoptosis of mouse retinal photoreceptors. In this study, we investigated AP-1 and Oct-1 DNA binding activity and AP-1 complex composition in the mouse retina during light-induced photoreceptor apoptosis. AP-1 DNA binding activity was low in dark-adapted animals but was transiently elevated within 12 h after exposure of mice to apoptosis-inducing levels of white fluorescent light. Maximal AP-1 activity was found 6 h after light-exposure. Antibody interference analysis at 6 h after damaging light exposure and under normal light conditions revealed that the major fraction of AP-1 consists of c-Fos/JunD heterodimers in both situations. In contrast to AP-1, Oct-1 DNA binding activity was maximal in dark-adapted animals and was reduced during photoreceptor apoptosis. 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| subjects | Animals AP-1 Apoptosis Apoptosis - radiation effects Biological and medical sciences Dark Adaptation Development. Senescence. Regeneration. Transplantation DNA - metabolism DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Host Cell Factor C1 Light Male Mice Mice, Inbred C57BL Mouse retina Oct-1 Octamer Transcription Factor-1 Photoreceptor Cells - cytology Photoreceptor Cells - radiation effects Retina - metabolism Time Factors Transcription factor Transcription Factor AP-1 - metabolism Transcription Factors - metabolism Vertebrates: nervous system and sense organs |
| title | Differential DNA binding activities of the transcription factors AP-1 and Oct-1 during light-induced apoptosis of photoreceptors |
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