Inhibition of Phosphatidylcholine Biosynthesis following Induction of Apoptosis in HL-60 Cells

Induction of apoptosis in HL-60 cells, using a variety of cytotoxic drugs, resulted, in all cases, in inhibition of CDP-choline:1,2-diacylglycerol choline phosphotransferase, leading to an accumulation of its substrate, CDP-choline, and inhibition of phosphatidylcholine biosynthesis. Incubation of t...

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Veröffentlicht in:	The Journal of biological chemistry 1999-07, Vol.274 (28), p.19686-19692
Hauptverfasser:	Anthony, M L, Zhao, M, Brindle, K M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Apoptosis - drug effects Benzophenanthridines Camptothecin - pharmacology Choline - metabolism Cytidine Diphosphate Choline - metabolism Diacylglycerol Cholinephosphotransferase - antagonists & inhibitors Enzyme Inhibitors - pharmacology Etoposide - pharmacology Farnesol - pharmacology Flow Cytometry HL-60 Cells Humans Hydrogen-Ion Concentration Phenanthridines - pharmacology Phosphatidylcholines - biosynthesis Phosphatidylcholines - pharmacology Phosphorylcholine - metabolism
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