Antihyperlipidaemic Effect of Gymnema montanum: A Study on Lipid Profile and Fatty Acid Composition in Experimental Diabetes
: In the present study, the antihyperlipidaemic efficacy of ethanol extract of Gymnema montanum leaves was investigated in alloxan‐induced diabetic rats and the effect was compared to standard hypoglycaemic drug, glibenclamide. Male adult albino Wistar rats were injected with freshly prepared solu...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2008-12, Vol.103 (6), p.538-545 |
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| creator | Ramkumar, Kunga Mohan Vijayakumar, Ramasamy Subramaniam Ponmanickam, Ponnirul Velayuthaprabhu, Shanmugan Archunan, Govindaraju Rajaguru, Palanisamy |
| description | : In the present study, the antihyperlipidaemic efficacy of ethanol extract of Gymnema montanum leaves was investigated in alloxan‐induced diabetic rats and the effect was compared to standard hypoglycaemic drug, glibenclamide. Male adult albino Wistar rats were injected with freshly prepared solution of alloxan monohydrate (150 mg/kg body weight) to induce diabetes. After 2 weeks, the rats with moderate diabetes were administered G. montanum leaves (200 mg/kg body weight) for 21 days by gastric lavage, after which serum, liver and kidney samples were analysed for lipid profile, lipoprotein changes and fatty acid composition. While the alloxan‐induced diabetic rats showed a significant increase in the levels of cholesterol, triglycerides and free fatty acids, the levels in the animals treated with G. montanum leaves were considerably reduced and restored to near normal values. Antihyperlipidaemic effects of G. montanum leaves were found to be comparable with that of glibenclamide. Similarly, G. montanum leaves treatment resulted in reversal of alterations observed in the plasma lipoproteins (high‐density lipoprotein, low‐density lipoprotein and very high‐density lipoprotein‐cholesterol) and fatty acid composition in serum, liver and kidney of alloxan‐induced rats. Our study suggests that phytochemicals present in G. montanum may play an important role in suppressing the elevated lipid profile in diabetes and may be useful for the prevention and/or early treatment of diabetes‐associated hyperlipidaemia. |
| doi_str_mv | 10.1111/j.1742-7843.2008.00320.x |
| format | Article |
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Male adult albino Wistar rats were injected with freshly prepared solution of alloxan monohydrate (150 mg/kg body weight) to induce diabetes. After 2 weeks, the rats with moderate diabetes were administered G. montanum leaves (200 mg/kg body weight) for 21 days by gastric lavage, after which serum, liver and kidney samples were analysed for lipid profile, lipoprotein changes and fatty acid composition. While the alloxan‐induced diabetic rats showed a significant increase in the levels of cholesterol, triglycerides and free fatty acids, the levels in the animals treated with G. montanum leaves were considerably reduced and restored to near normal values. Antihyperlipidaemic effects of G. montanum leaves were found to be comparable with that of glibenclamide. Similarly, G. montanum leaves treatment resulted in reversal of alterations observed in the plasma lipoproteins (high‐density lipoprotein, low‐density lipoprotein and very high‐density lipoprotein‐cholesterol) and fatty acid composition in serum, liver and kidney of alloxan‐induced rats. Our study suggests that phytochemicals present in G. montanum may play an important role in suppressing the elevated lipid profile in diabetes and may be useful for the prevention and/or early treatment of diabetes‐associated hyperlipidaemia.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/j.1742-7843.2008.00320.x</identifier><identifier>PMID: 19067681</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - analysis ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - enzymology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Acids - metabolism ; Gymnema ; Hyperlipidemias - blood ; Hyperlipidemias - drug therapy ; Hyperlipidemias - enzymology ; Hypolipidemic Agents - therapeutic use ; Insulin - blood ; Kidney - enzymology ; Lipids - blood ; Liver - enzymology ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - therapeutic use ; Plant Leaves ; Plant Preparations - therapeutic use ; Rats ; Rats, Wistar</subject><ispartof>Basic & clinical pharmacology & toxicology, 2008-12, Vol.103 (6), p.538-545</ispartof><rights>2008 The Authors. 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Male adult albino Wistar rats were injected with freshly prepared solution of alloxan monohydrate (150 mg/kg body weight) to induce diabetes. After 2 weeks, the rats with moderate diabetes were administered G. montanum leaves (200 mg/kg body weight) for 21 days by gastric lavage, after which serum, liver and kidney samples were analysed for lipid profile, lipoprotein changes and fatty acid composition. While the alloxan‐induced diabetic rats showed a significant increase in the levels of cholesterol, triglycerides and free fatty acids, the levels in the animals treated with G. montanum leaves were considerably reduced and restored to near normal values. Antihyperlipidaemic effects of G. montanum leaves were found to be comparable with that of glibenclamide. Similarly, G. montanum leaves treatment resulted in reversal of alterations observed in the plasma lipoproteins (high‐density lipoprotein, low‐density lipoprotein and very high‐density lipoprotein‐cholesterol) and fatty acid composition in serum, liver and kidney of alloxan‐induced rats. Our study suggests that phytochemicals present in G. montanum may play an important role in suppressing the elevated lipid profile in diabetes and may be useful for the prevention and/or early treatment of diabetes‐associated hyperlipidaemia.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Diabetes Mellitus, Experimental - enzymology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty Acids - metabolism</subject><subject>Gymnema</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hyperlipidemias - enzymology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Insulin - blood</subject><subject>Kidney - enzymology</subject><subject>Lipids - blood</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Leaves</subject><subject>Plant Preparations - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGP0zAQhSMEYpeFv4B8gVvD2E5iB4lDt3QXpEqsxHK2XHsiXCVxiB3RSPx4HFqVI_jikf29N_a8LCMUcprWu0NORcFWQhY8ZwAyB-AM8uOT7Ppy8fRS8_IqexHCAYCJgsLz7IrWUIlK0uvs17qP7vs84Ni6wVmNnTNk2zRoIvENuZ-7HjtNOt9H3U_de7ImX-NkZ-J7slsU5GH0jWuR6N6SOx3jTNYmHW98N_jgokug68n2mFq4DpNNSz46vceI4WX2rNFtwFfn_Sb7drd93Hxa7b7cf96sdytTCAkra6VEtDXwCvYaTFWWlkmBhTUa6qKqZcGYtgyZQNpwwTmWRsIemNXWVMBvsrcn32H0PyYMUXUuGGxb3aOfgkoOglMo_wnSuqCCM5pAeQLN6EMYsVFD-p0eZ0VBLRGpg1qmr5Yk1BKR-hOROibp63OPad-h_Ss8Z5KAN2dAB6PbZtS9ceHCMZAlq0WVuA8n7mca__zfD1C3m4fHVPHfHUetKQ</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Ramkumar, Kunga Mohan</creator><creator>Vijayakumar, Ramasamy Subramaniam</creator><creator>Ponmanickam, Ponnirul</creator><creator>Velayuthaprabhu, Shanmugan</creator><creator>Archunan, Govindaraju</creator><creator>Rajaguru, Palanisamy</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Antihyperlipidaemic Effect of Gymnema montanum: A Study on Lipid Profile and Fatty Acid Composition in Experimental Diabetes</title><author>Ramkumar, Kunga Mohan ; Vijayakumar, Ramasamy Subramaniam ; Ponmanickam, Ponnirul ; Velayuthaprabhu, Shanmugan ; Archunan, Govindaraju ; Rajaguru, Palanisamy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4780-dd88eed90360ba0c655d287e4dca094698422ad2e27e1f3733e5c80b02dadc603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Diabetes Mellitus, Experimental - enzymology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty Acids - metabolism</topic><topic>Gymnema</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Hyperlipidemias - enzymology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Insulin - blood</topic><topic>Kidney - enzymology</topic><topic>Lipids - blood</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Leaves</topic><topic>Plant Preparations - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramkumar, Kunga Mohan</creatorcontrib><creatorcontrib>Vijayakumar, Ramasamy Subramaniam</creatorcontrib><creatorcontrib>Ponmanickam, Ponnirul</creatorcontrib><creatorcontrib>Velayuthaprabhu, Shanmugan</creatorcontrib><creatorcontrib>Archunan, Govindaraju</creatorcontrib><creatorcontrib>Rajaguru, Palanisamy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramkumar, Kunga Mohan</au><au>Vijayakumar, Ramasamy Subramaniam</au><au>Ponmanickam, Ponnirul</au><au>Velayuthaprabhu, Shanmugan</au><au>Archunan, Govindaraju</au><au>Rajaguru, Palanisamy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihyperlipidaemic Effect of Gymnema montanum: A Study on Lipid Profile and Fatty Acid Composition in Experimental Diabetes</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2008-12</date><risdate>2008</risdate><volume>103</volume><issue>6</issue><spage>538</spage><epage>545</epage><pages>538-545</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>: In the present study, the antihyperlipidaemic efficacy of ethanol extract of Gymnema montanum leaves was investigated in alloxan‐induced diabetic rats and the effect was compared to standard hypoglycaemic drug, glibenclamide. Male adult albino Wistar rats were injected with freshly prepared solution of alloxan monohydrate (150 mg/kg body weight) to induce diabetes. After 2 weeks, the rats with moderate diabetes were administered G. montanum leaves (200 mg/kg body weight) for 21 days by gastric lavage, after which serum, liver and kidney samples were analysed for lipid profile, lipoprotein changes and fatty acid composition. While the alloxan‐induced diabetic rats showed a significant increase in the levels of cholesterol, triglycerides and free fatty acids, the levels in the animals treated with G. montanum leaves were considerably reduced and restored to near normal values. Antihyperlipidaemic effects of G. montanum leaves were found to be comparable with that of glibenclamide. 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| subjects | Animals Biological and medical sciences Blood Glucose - analysis Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - enzymology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty Acids - metabolism Gymnema Hyperlipidemias - blood Hyperlipidemias - drug therapy Hyperlipidemias - enzymology Hypolipidemic Agents - therapeutic use Insulin - blood Kidney - enzymology Lipids - blood Liver - enzymology Male Medical sciences Pharmacology. Drug treatments Phytotherapy Plant Extracts - therapeutic use Plant Leaves Plant Preparations - therapeutic use Rats Rats, Wistar |
| title | Antihyperlipidaemic Effect of Gymnema montanum: A Study on Lipid Profile and Fatty Acid Composition in Experimental Diabetes |
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