Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation
To assess the outcome of patients diagnosed to have liver metastasis by ultrasonography, following curative-intent resection of colorectal adenocarcinoma. Prospective study. Regional hospital, Hong Kong. A total of 650 patients who underwent curative-intent resection of colorectal adenocarcinoma bet...
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| Veröffentlicht in: | Hong Kong medical journal = Xianggang yi xue za zhi 2008-12, Vol.14 (6), p.432-436 |
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| creator | Cheng, K C Yeung, Y P Lau, P Yy Meng, W Cs |
| description | To assess the outcome of patients diagnosed to have liver metastasis by ultrasonography, following curative-intent resection of colorectal adenocarcinoma.
Prospective study.
Regional hospital, Hong Kong.
A total of 650 patients who underwent curative-intent resection of colorectal adenocarcinoma between January 2000 and December 2006.
Pattern of liver recurrence, treatment and outcome after recurrence, and overall patient survival.
Of the 650 patients, 553 (85%) were followed up per protocol. Of 104 patients who developed systemic recurrence, 45 (43%) had liver-only metastases. The resection rate for liver metastases was 38% (17/45). The median survival of such patients was significantly longer than those who did not undergo liver metastasectomy (50 vs 26 months, P=0.017).
Our ultrasonography-based surveillance protocol was low-cost, simple, and effective in detecting asymptomatic liver metastases, so that curative-intent metastasectomy could be performed. Further prospective studies are required to determine the optimal frequency and imaging mode for surveillance, so as to improve the resectability of liver-only colorectal metastases as well as overall patient survival. |
| format | Article |
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Prospective study.
Regional hospital, Hong Kong.
A total of 650 patients who underwent curative-intent resection of colorectal adenocarcinoma between January 2000 and December 2006.
Pattern of liver recurrence, treatment and outcome after recurrence, and overall patient survival.
Of the 650 patients, 553 (85%) were followed up per protocol. Of 104 patients who developed systemic recurrence, 45 (43%) had liver-only metastases. The resection rate for liver metastases was 38% (17/45). The median survival of such patients was significantly longer than those who did not undergo liver metastasectomy (50 vs 26 months, P=0.017).
Our ultrasonography-based surveillance protocol was low-cost, simple, and effective in detecting asymptomatic liver metastases, so that curative-intent metastasectomy could be performed. Further prospective studies are required to determine the optimal frequency and imaging mode for surveillance, so as to improve the resectability of liver-only colorectal metastases as well as overall patient survival.</description><identifier>ISSN: 1024-2708</identifier><identifier>EISSN: 2226-8707</identifier><identifier>PMID: 19060341</identifier><language>eng</language><publisher>China: Hong Kong Academy of Medicine</publisher><subject>Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Aged ; Cancer ; Colorectal cancer ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Female ; Humans ; Liver ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Male ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local ; Patients ; Prospective Studies ; Surveillance ; Treatment Outcome ; Ultrasonic imaging ; Ultrasonography</subject><ispartof>Hong Kong medical journal = Xianggang yi xue za zhi, 2008-12, Vol.14 (6), p.432-436</ispartof><rights>2008. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.hkmj.org/about/website.html</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19060341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, K C</creatorcontrib><creatorcontrib>Yeung, Y P</creatorcontrib><creatorcontrib>Lau, P Yy</creatorcontrib><creatorcontrib>Meng, W Cs</creatorcontrib><title>Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation</title><title>Hong Kong medical journal = Xianggang yi xue za zhi</title><addtitle>Hong Kong Med J</addtitle><description>To assess the outcome of patients diagnosed to have liver metastasis by ultrasonography, following curative-intent resection of colorectal adenocarcinoma.
Prospective study.
Regional hospital, Hong Kong.
A total of 650 patients who underwent curative-intent resection of colorectal adenocarcinoma between January 2000 and December 2006.
Pattern of liver recurrence, treatment and outcome after recurrence, and overall patient survival.
Of the 650 patients, 553 (85%) were followed up per protocol. Of 104 patients who developed systemic recurrence, 45 (43%) had liver-only metastases. The resection rate for liver metastases was 38% (17/45). The median survival of such patients was significantly longer than those who did not undergo liver metastasectomy (50 vs 26 months, P=0.017).
Our ultrasonography-based surveillance protocol was low-cost, simple, and effective in detecting asymptomatic liver metastases, so that curative-intent metastasectomy could be performed. Further prospective studies are required to determine the optimal frequency and imaging mode for surveillance, so as to improve the resectability of liver-only colorectal metastases as well as overall patient survival.</description><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Aged</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Surveillance</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><issn>1024-2708</issn><issn>2226-8707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkFtLxDAQhYMo7rr6FyQg-FZI0iZpH2XxBoIP6nNJ06mbpU1qLivinzeL64swMDB85zDnHKElY0wUtSTyGC0pYVXBJKkX6CyELSGs5g05RQvaEEHKii7R90vyOzDjqKwGrGyPXYraTYDdgEezA48niCrkMQEbi2cVDdgY8KeJG6zd6DzoqEas9w4ef24c3qgeJ9uDf3cWsE4-a3ZQGBuzErsZ9gdnz9HJoMYAF4e9Qm93t6_rh-Lp-f5xffNUzJSzWLBGyb5ueKeqElSlK8XlQKFXtGNCKFZ2ouQAHaGl5GToFaOESDbUTFYaOC1X6PrXd_buI0GI7WSChn1mcCm0oqllboZl8OofuHXJ2_xby2RmRCU4z9TlgUrdBH07ezMp_9X-lVr-AMOidhg</recordid><startdate>200812</startdate><enddate>200812</enddate><creator>Cheng, K C</creator><creator>Yeung, Y P</creator><creator>Lau, P Yy</creator><creator>Meng, W Cs</creator><general>Hong Kong Academy of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BVBZV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200812</creationdate><title>Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation</title><author>Cheng, K C ; Yeung, Y P ; Lau, P Yy ; Meng, W Cs</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p152t-29a7d895ba43ea4c4a57f1eda1b266a23b635eeb013750fda210072f8274ce513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Aged</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Surveillance</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, K C</creatorcontrib><creatorcontrib>Yeung, Y P</creatorcontrib><creatorcontrib>Lau, P Yy</creatorcontrib><creatorcontrib>Meng, W Cs</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East & South Asia Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, K C</au><au>Yeung, Y P</au><au>Lau, P Yy</au><au>Meng, W Cs</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation</atitle><jtitle>Hong Kong medical journal = Xianggang yi xue za zhi</jtitle><addtitle>Hong Kong Med J</addtitle><date>2008-12</date><risdate>2008</risdate><volume>14</volume><issue>6</issue><spage>432</spage><epage>436</epage><pages>432-436</pages><issn>1024-2708</issn><eissn>2226-8707</eissn><abstract>To assess the outcome of patients diagnosed to have liver metastasis by ultrasonography, following curative-intent resection of colorectal adenocarcinoma.
Prospective study.
Regional hospital, Hong Kong.
A total of 650 patients who underwent curative-intent resection of colorectal adenocarcinoma between January 2000 and December 2006.
Pattern of liver recurrence, treatment and outcome after recurrence, and overall patient survival.
Of the 650 patients, 553 (85%) were followed up per protocol. Of 104 patients who developed systemic recurrence, 45 (43%) had liver-only metastases. The resection rate for liver metastases was 38% (17/45). The median survival of such patients was significantly longer than those who did not undergo liver metastasectomy (50 vs 26 months, P=0.017).
Our ultrasonography-based surveillance protocol was low-cost, simple, and effective in detecting asymptomatic liver metastases, so that curative-intent metastasectomy could be performed. Further prospective studies are required to determine the optimal frequency and imaging mode for surveillance, so as to improve the resectability of liver-only colorectal metastases as well as overall patient survival.</abstract><cop>China</cop><pub>Hong Kong Academy of Medicine</pub><pmid>19060341</pmid><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - pathology Adenocarcinoma - surgery Aged Cancer Colorectal cancer Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Female Humans Liver Liver Neoplasms - diagnostic imaging Liver Neoplasms - mortality Liver Neoplasms - secondary Male Metastasis Middle Aged Neoplasm Recurrence, Local Patients Prospective Studies Surveillance Treatment Outcome Ultrasonic imaging Ultrasonography |
| title | Surveillance and outcome of liver metastasis in patients with colorectal cancer who had undergone curative-intent operation |
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