Differential effects of Bcl-2 overexpression on hippocampal CA1 neurons and dentate granule cells following hypoxic ischemia in adult mice

In contrast to its known anti‐apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl‐2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of ove...

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Veröffentlicht in:	Journal of neuroscience research 1999-07, Vol.57 (1), p.1-12
Hauptverfasser:	Wang, Huai-Dong, Fukuda, Takaichi, Suzuki, Tomoko, Hashimoto, Koichi, Liou, Shyh-Yuh, Momoi, Takashi, Kosaka, Toshio, Yamamoto, Kenji, Nakanishi, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Bcl-2 caspase-3 chromatin condensation Dentate Gyrus - metabolism Dentate Gyrus - pathology hippocampus Hippocampus - metabolism Hippocampus - pathology Histocytochemistry Humans Hypoxia, Brain - metabolism Hypoxia, Brain - pathology hypoxic ischemia In Situ Nick-End Labeling Mice Mice, Transgenic Microscopy, Confocal Microscopy, Electron Neurons - pathology Proto-Oncogene Proteins c-bcl-2 - biosynthesis transgenic mouse ultrastructure
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